The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system
Cancer LettersPublished 1 July 1992
Steven M. Hill, Louaine L. Spriggs, Mary Alice Simon, Hitoyuki Muraoka, David E. Blask
Citations138
SJR quartileQ1
SJR score2.76
SNIP1.54
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TL;DR
The pineal hormone, melatonin, was examined for its capacity to modulate the proliferation of a panel of human breast cancer cell lines and it appears that the antiproliferative effects of melatonin are mediated through the estrogen-response pathway.
Abstract
The pineal hormone, melatonin, was examined for its capacity to modulate the proliferation of a panel of human breast cancer cell lines. Melatonin inhibited, to a varying extent, the proliferation of all three estrogen-responsive cell lines, but had no effect on estrogen-insensitive breast tumor cell lines. Melatonin was also able to specifically block estrogen-induced proliferation in MCF-7 breast cancer cells. However, this action was abolished in the presence of tamoxifen. Therefore, it appears that the antiproliferative effects of melatonin are mediated through the estrogen-response pathway.
Keywords
Neuroscience
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