Gene-Environment Interaction in Alzheimer’s Disease:A Potential Role for Cholesterol
NeuroepidemiologyPublished 1 January 1998
Vijay Chandra, Rajesh Pandav
Citations66
SJR quartileQ1
SJR score1.39
SNIP1.24
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TL;DR
An interaction between serum cholesterol levels and σ4 genotype is proposed and the evidence for this gene-environment interaction is discussed.
Abstract
Alzheimer's disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include 'causative' genes which are rare and a 'susceptibility' gene (sigma4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer's disease. An interaction between serum cholesterol levels and sigma4 genotype is proposed. The evidence for this gene-environment interaction is discussed.
Keywords
Computer ScienceMedicineNeuroscience
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