Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function
Neural PlasticityPublished 1 January 2013Open access
Yi Ren, Wise Young
Citations129
SJR quartileQ2
SJR score1.10
SNIP1.08
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Abstract
Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Macrophages are heterogeneous cells with extensive functional plasticity and have the capacity to switch phenotypes by factors present in the inflammatory microenvironment of the injured spinal cord. This review will discuss the role of different polarized macrophages and the potential effect of macrophage-based therapies for SCI.
Keywords
Immunology and MicrobiologyMedicineNeuroscience
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77 Citations2011John C. Gensel, Dustin J. Donnelly +1 more
This review provides a comprehensive overview of current SCI clinical trials that are intended to promote neuroprotection, axon regeneration or cell replacement and the potential impact of each trial is discussed in the context of CNS macrophage biology.
World NeurosurgeryMesenchymal Stem Cell Transplantation Reduces Glial Cyst and Improves Functional Outcome After Spinal Cord Compression
75 Citations2012Marina Boido, Diego Garbossa +3 more
Grafted MSCs remained permanently undifferentiated and sensory and motor tests showed that MSC cell therapy results in improvement on a battery of behavioral tests compared with control mice, making them promising treatments for central nervous system pathologies.
Journal of NeuroscienceBeneficial Effects of αB-Crystallin in Spinal Cord Contusion Injury
71 Citations2012Armelle Klopstein, Eva Santos-Nogueira +5 more
The findings suggest that administration of recombinant human αB-crystallin may be a good therapeutic approach for treating acute spinal cord injury, for which there is currently no effective treatment.
The Journal of ImmunologyStat3-Dependent Induction of p19INK4D by IL-10 Contributes to Inhibition of Macrophage Proliferation
65 Citations2000Anne-Marie O’Farrell, David Parry +5 more
Investigation of the mechanism of growth arrest found that IL-10 treatment increases expression of the cyclin-dependent kinase inhibitors p19INK4D and p21CIP1 in macrophages, indicating that Stat3-dependent induction of p19inks4d and Stat3
NeuroscienceGranulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury
61 Citations2013Yingxin Guo, Huanshui Zhang +5 more
It is suggested that administration of G-CSF within the first 72h after spinal cord injury might reduce early inflammation-induced detrimental effect and promote an anti-inflammatory response that favors repair via improving alternative activation of microglia.
Molecular NeurobiologyPhospholipase A2 and its Molecular Mechanism after Spinal Cord Injury
60 Citations2010Nai‐Kui Liu, Xiao‐Ming Xu
This review outlines the current knowledge of the PLA2 in the spinal cord with an emphasis being placed on the possible roles of PLA1 in mediating the secondary SCI and the loss of membrane integrity, inflammation, oxidative stress, and subsequent neuronal injury.
Journal of NeuroimmunologyTemporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the lys-egfp-ki mouse model
60 Citations2013Sakina G. Thawer, Leah Mawhinney +5 more
The study offers new insight into the cellular inflammatory response that occurs after SCI and suggests that the timing and targets of anti-inflammatory therapies may be crucial to maximize neuroprotection at the acute and more chronic stages of SCI.
Journal of Biomedicine and BiotechnologyHuman Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis
60 Citations2012Sang‐In Park, Jung Yeon Lim +5 more
Journal of NeuroinflammationMyelin-phagocytosing macrophages modulate autoreactive T cell proliferation
58 Citations2011Jeroen F. J. Bogie, Piet Stinissen +2 more
It is demonstrated that myelin-phagocytosing macrophages inhibit TCR-triggered lymphocyte proliferation in an antigen-independent manner and results from this study indicate that myelinated macrophage fulfill a dual role in vivo.
Journal of NeurochemistryInflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord
57 Citations2010Matthew W. Buczynski, Camilla I. Svensson +8 more
Biological and Pharmaceutical BulletinLeukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain
57 Citations2011Koichi Noguchi, Masamichi Okubo
The findings suggest that the increase of LT synthesis in spinal microglia produced via p38 mitogen-activated protein kinase (MAPK) plays a role in the generation of neuropathic pain.
Experimental NeurologyTNF-α triggers rapid membrane insertion of Ca2+ permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury
56 Citations2012Hong Yin, Cheng-I Hsu +4 more
Data support the idea that prolonged TNF-α elevation, as may be induced by glial activation, acts in part by increasing the numbers of Ca-perm AMPAr on MNs to enhance injurious excitotoxic effects of deficient astrocytic glutamate transport.
World Journal of Stem CellsHuman umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model
54 Citations2012Sahar M Greish
MSC enhance the efficacy of CFA-induced arthritis treatment, most likely through the modulation of the expression of cytokines and amelioration of pathological changes in joints.
PLoS ONEGlial Tumor Necrosis Factor Alpha (TNFα) Generates Metaplastic Inhibition of Spinal Learning
53 Citations2012J. Russell Huie, Kyle M. Baumbauer +5 more
A crucial role is found for glial TNFα in undermining spinal learning, and the therapeutic potential of inhibiting TNF α activity to rescue and restore adaptive spinal plasticity to the injured spinal cord is demonstrated.
Journal of NeuroscienceLicofelone Modulates Neuroinflammation and Attenuates Mechanical Hypersensitivity in the Chronic Phase of Spinal Cord Injury
52 Citations2013Jennifer N. Dulin, Edward D. Karoly +3 more
Novel evidence of inflammation and oxidative stress within spinal cord tissue far into the chronic phase of SCI is provided, and a role for inflammatory modulation of mechanical sensitivity in the Chronic phase of injury is demonstrated.
Acta NeuropathologicaColony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion
47 Citations1996O. L. Berezovskaya, Dušica Maysinger +1 more
It is proposed that neuron rescue in ischemic damage is potentiated byCSF-1 signaling through CSF-2 receptor in the neurons through which it is upregulated in neurons at the site of the lesion.
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