A Comparison Between Antigen-Laden Cells and Dendritic Cells in Afferent and Efferent Lymph
Published 1 January 1985
Mark T. Drayson, David R. Canning, Eric B. Bell
Citations2
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TL;DR
The importance of antigen presenting cells in the initiation of an immune response has focused attention on two contrasting cell types — the antigen-laden (Ag-L) cell and the dendritic cell (DC) alias the “veiled” cell or interdigitating cell of the lymph node (LN) paracortex.
Abstract
The importance of antigen presenting cells in the initiation of an immune response has focused attention on two contrasting cell types — the antigen-laden (Ag-L) cell (a macrophage-1ike cell) and the dendritic cell (DC) alias the "veiled" cell or interdigitating cell of the lymph node (LN) paracortex. Whereas the DC is recognized by a high surface density of Ia molecules and can be found in afferent lymph,1–4 the Ag-L cell is found in low frequency (<0.01%) in the efferent lymph of the thoracic duct, lacks Ia6 and appears to transport injected antigens.7 Functionally, the DC stimulates T cell proliferation3,8,9 while the Ag-L cell is active in triggering specific memory cells into antibody synthesis on adoptive transfer. 5,6
Keywords
Immunology and Microbiology
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