ABNORMAL IMMUNOLOGICAL REACTIONS IN DISSEMINATED SCLEROSIS: A Preliminary Report
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TL;DR
The peculiar reactions seen in disseminated sclerosis are described and contrasted with those obtained in a group of psychotic patients in whom the meninges were otherwise normal.
Abstract
It is now established that the injection of tuber- culin into the cerebrospinal fluid (C.S.F.) of a sensitized subject evokes a wave of inflammation involving the leptomeninges and, to some extent, the vessels of the brain and spinal cord. The properties of this reaction have been studied in both man (Smith and Vollum, 1950; Swithinbank, Smith, and Vollum, 1953) and animals It is undoubtedly a true antibody-antigen response; it exerts a profound effect on the per- meability of the blood-C.S.F. barrier