Combined-modality treatment of small-cell lung cancer: Randomized comparison of three induction chemotherapies followed by maintenance chemotherapy with or without radiotherapy to the chest
Annals of OncologyPublished 1 December 1994Open access
R Joss, P. Alberto, E. A. Bleher, Christian Ludwig, P Siegenthaler, Giovanni Martinelli
Citations24
SJR quartileQ1
SJR score19.07
SNIP10.48
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TL;DR
In patients with extensive disease in partial remission after induction treatment, combined maintenance therapy had a more significant adverse effect on survival than maintenance chemotherapy alone (median survival in the maintenance phase of 148 days versus 239 days, p = 0.011).
Abstract
We conclude that the combination of adriamycin, etoposide and cisplatin is an active induction treatment. Consolidating chest irradiation is contraindicated in patients with extensive disease in partial remission after induction when given in a sequential manner, as in our trial.
Keywords
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