The Reversibility of Disuse Osteoporosis: Experimental Studies in the Adult Rat
Acta Orthopaedica ScandinavicaPublished 1 August 1972
S Mattsson
Citations49
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
(1972). The Reversibility of Disuse Osteoporosis: Experimental Studies in the Adult Rat. Acta Orthopaedica Scandinavica: Vol. 43, No. sup144, pp. 1-135.
Keywords
Medicine
Multivariate Statistical Methods
5,617 Citations2008
PEDIATRICSThe Parathyroid Glands and Metabolic Bone Disease
926 Citations1949Lawson Wilkins
The new monograph presents in clear and concise form the accumulation of a quarter century of investigations and gives Albright's views as they stand today.
ScienceMeasurement of Bone Mineral in vivo: An Improved Method
832 Citations1963John Cameron, James A. Sorenson
The mineral content of bone can be determined by measuring the absorption by bone of a monochromatic, low-energy photon beam which originates in a radioactive source and is measured by counting with a scintillation detector.
Clinical RadiologyThe radiological diagnosis of osteoporosis: A new approach
743 Citations1960Ellis Barnett, B. E. C. Nordin
This method has been applied to about 150 patients suspected of metabolic bone disease, and abnormal results were obtained in eighty-seven patients, and Arbitrary normal standards have been established in a control series of 125 adult outpatients.
The American Journal of MedicineEffects of immobilization upon various metabolic and physiologic functions of normal men
614 Citations1948John E. Deitrick, G. Donald Whedon +1 more
Experiments indicated that the legs were the principal site of changes responsible for this deterioration and suggested that increased venous engorgement, increased extravascular fluid, capillary fragility and impaired venous or muscle tone play a re exercise tolerance and leg girth required four to six weeks and the reclining pulse rate more than six weeks.
Analytical ChemistryDetermination of Calcium and Magnesium in Urine by Atomic Absorption Spectroscopy
374 Citations1961J. B. Willis
Journal of Bone and Joint SurgeryQuantitative Microradiographic Studies of Normal and Osteoporotic Bone
361 Citations1965Jenifer Jowsey, Patrick J. Kelly +4 more
Quantitative microradiography has been developed for studying bone turnover and has been applied to a study of normal and osteoporotic human bone, demonstrating that this method is reproducible and provides an accurate measure of bone formation and resorption.
JNCI Journal of the National Cancer InstituteBone Localization of the Tetracyclines
322 Citations1957Robert Austin Milch, David P. Rall +1 more
PubMedA reliable in vivo measurement of bone-mineral content.
273 Citations1967J A Buckwalter, J Martin +1 more
Development of methods to detect and monitor subtle changes in cartilage metabolism and identify the joint changes that precede loss of articular cartilage may make it possible to detect the earliest signs of osteoarthritis, when therapeutic interventions have the greatest potential for preventing progression of the disease.
Journal of Bone and Joint SurgeryExperimental Immobilization and Remobilization of Rat Knee Joints
266 Citations1960E. Burke Evans, G. W. N. Eggers +2 more
A progression of morphological changes consequent to restriction of motion was found, and it was possible to gain some indication of the degree of reversibility of these changes after varying periods of immobilization and remobilization.
Journal of Bone and Joint SurgeryProliferation, Regeneration, and Repair of Articular Cartilage of Immature Animals
193 Citations1962Rocco A. Calandruccio, W. Scott Gilmer
Repair of articular cartilage of the femoral condyles in immature dogs was studied histologically at various time intervals after injury in thirty complete (full-thickness) and ten incomplete defects in the weight-bearing surface.
The American Journal of MedicineRadiocalcium metabolism in disuse osteoporosis in man
181 Citations1962Robert P. Heaney
Evidence precludes any possible role of parathyroid hormone in the genesis of disuse osteoporosis.
Journal of Bone and Joint Surgery - British VolumeMUSCLE ACTION, BONE RAREFACTION AND BONE FORMATION
175 Citations1958Max Geiser, Joseph Trueta
Evidence is found that during muscle action pressure forces are transmitted through the bone, and that the presence or absence of these pressure forces conditions the balance between bone formation and bone removal.
Journal of Bone and Joint SurgeryThe Water Content of Bone
171 Citations1957Robert A. Robinson, Stuart R. Elliott
In specimens from normal puppies, those with a very low density when hydrated have a slightly lower density when dry and a slightly smaller ratio of ash + carbon dioxide space to organic component.
Journal of Bone and Joint SurgeryBone Density and Composition
156 Citations1966Karl H. Mueller, A. Trías +1 more
Journal of Bone and Joint SurgeryA Reliable In Vivo Measurement of Bone-Mineral Content
145 Citations1967James A. Sorenson, John Cameron
Development of methods to detect and monitor subtle changes in cartilage metabolism and identify the joint changes that precede loss of articular cartilage may make it possible to detect the earliest signs of osteoarthritis, when therapeutic interventions have the greatest potential for preventing progression of the disease.
Journal of Bone and Joint SurgeryThe In Vivo Distribution of Tetracyclines in Canine Bone
125 Citations1962William H. Harris, Robert H. Jackson +1 more
The tetracyclines do mark all sites of active new-bone formation and can be used as reliable intravital stains in properly designed and properly controlled experiments for the accurate determination of rates of accretion of bone.
Journal of Bone and Joint SurgeryDegeneration of Immobilized Knee Joints in Rats
118 Citations1965T. H. THAXTER, R A Mann +1 more
This is a histological and autoradiographic study of certain factors responsible for degeneration occurring in immobilized normal rat knees.
Annals of the Rheumatic DiseasesRadiological Signs of Rheumatoid Arthritis
102 Citations1956Jan Kellgren, F. Bier
It is suggested that the observer error in reading x rays of the hands and feet for rheumatoid arthritis may not be very great, and it has become necessary to know more about the reproducibility of such x-ray gradings by any given individual.
Journal of Clinical InvestigationMETABOLIC STUDIES IN PARALYTIC ACUTE ANTERIOR POLIOMYELITIS. II. ALTERATIONS IN CALCIUM AND PHOSPHORUS METABOLISM 1
101 Citations1957G. Donald Whedon, Ephraim Shorr +2 more
Journal of Bone and Joint Surgery - British VolumeTHE NATURE OF THE BONE CHANGES ASSOCIATED WITH NERVE INJURIES AND DISUSE
97 Citations1954J. A. Gillespie
No evidence could be obtained that nerves exert any specific, trophic influence on bone, but the altered properties of the bones of a paralysed limb are due almost entirely to a loss in the quantity of bone; bone quality is only slightly altered.
Journal of Bone and Joint Surgery - British VolumeTHE INFLUENCE OF IMMOBILISATION ON BONE FORMATION AS EVALUATED BY OSSEOUS INCORPORATION OF TETRACYCLINES
89 Citations1964M Landry, H. Fleisch
In animals immobilised by tendon section the mechanical function becomes restored in the second week as a result of healing: this explains the rapid compensation for the initial loss of weight of the bones accompanied by a marked increase in tetracycline uptake.
The American Journal of MedicineThyrocalcitonin, osteoporosis and osteolysis
72 Citations1967Howard Rasmussen, Alan Tenenhouse
This review considers the problem of osteoporosis in the context of present knowledge (and its limitations) of the mechanisms of bone resorption and bone formation and considers the recent evidence that thyrocalcitonin and parathyroid hormone control metabolism by regulating the fluxes of calcium and magnesium across cellular and subcellular membranes.
The American Journal of MedicineThe syndrome of pulmonary stenosis with patent foramen ovale
64 Citations1949Arthur Selzer, William H. Carnes +3 more
Evidence is presented that pulmonary stenosis with patent foramen ovale is a well defined clinical entity with enough distinctive features to make possible diagnosis during life and represents a conspicuous exception to the rule that cyanotic congenital heart disease with dilated pulmonary arteries is unsuitable for surgical relief.
Journal of Bone and Joint SurgeryBipedal Rats and Mice
61 Citations1957Charles W. Goff, WALTER LANDMESSER
Journal of Bone and Joint Surgery - British VolumeSTUDIES ON BONE MATRIX IN NORMAL AND OSTEOPOROTIC BONE
41 Citations1962K. Little, Michael Kelly +1 more
Evidence has been produced to suggest that the immediate cause of many forms of osteoporosis is some local factor affecting the osteocytes, rather than a general chemical effect.
Acta Orthopaedica ScandinavicaThe Effect of Motor Denervation on Muscle and Bone in the Rabbit's Hind Limb
36 Citations1965Oved Kharmosh, Paul D. Saville
Pflügers Archiv - European Journal of PhysiologyUeber den Einfluss der Nervendurchschneidung auf die Ernährung, insbesondere auf die Form und die Zusammensetzung der Knochen
35 Citations1880Hermann Nasse
Eine Verminderung der unorganisehen Bestandtheile in dem Verh~iltniss zu den organischen, zumal des kohlensauren Kalkes zu dem phosphorsauren gefunden hatte.
The American Journal of MedicineEffect of the oscillating bed and tilt table on calcium, phosphorus and nitrogen metabolism in paraplegia
35 Citations1954Derek M. Wyse, C. J. PATTEE
An attempt was made in five paraplegic patients to imitate ambulation while the patients were still immobilized by means of the oscillating bed, as suggested by Whedon et al., and by the tilt table, and it is postulated that the "stresses and strains" on bone might primarily result from muscular contractions rather than weight-bearing or circulatory changes.
Calcified Tissue InternationalComparison of calcium kinetics in man and the rat
32 Citations1969Félix Bronner, Roger Lemaire
A formal comparison of calcium kinetics in man and the rat yields information consistent with the interpretation that the two systems are comparable, and rate constants may prove useful for interspecies comparisons, as well as for studies of the regulation of calcium metabolism.
Journal of Bone and Joint SurgeryCoxa Plana in the Dog
26 Citations1962Anders Hulth, Ingemar Norberg +1 more
The authors describe coxa plana in the dog with the aid of clinical examination, roentgenograms, histological examination, and microangiographs, which reveals the non-vascular state of the epiphysis together with hypervascularization of all the surrounding tissue.
Journal of Bone and Joint SurgeryAnalysis of Distribution of Ca45 in Dog Bone by a Quantitative Autoradiographic Method
24 Citations1965Jenifer Jowsey, W. LAFFERTY +1 more
JAMAIsotopic Tracers in Biochemistry and Physiology
23 Citations1953
Improved knowledge is perhaps best shown in thoracic surgery, when Brock and d'Abreu write of a clotted hremothorax and thoraco-abdominal wounds.
Calcified Tissue InternationalEffect of disuse osteoporosis on bone composition: the fate of bone matrix
21 Citations1968LeRoy Klein, Donald G. Kanefield +1 more
The data indicated that the major portion of the lost bone tissue in disuse osteoporosis is replaced by water, fat, and other unidentified organic materials rather than fibrous tissue, and that collagen is lost in equal proportion to mineral.
Experimental Biology and MedicineEffects of Fluoride Intake on Disuse Atrophy of Bone in Rats
21 Citations1966I. Gedalia, A. Schwartz +2 more
It is suggested that increased bone resorption is prevented by a reprecipitation of calcium as fluorapatite of low solubility on the surface of the bone crystals.
Acta Orthopaedica ScandinavicaSkeletal Changes of the Amputation Stump and the Femur on the Amputated Side: A Clinical Investigation
20 Citations1969J. A. Sevastikoglou, Urban Eriksson +1 more
Biochemical JournalThe effect of age and of the supply of phosphorus on the assimilation of calcium by the rat
19 Citations1947K. M. Henry, S. K. Kon
It is proposed in this paper to set forth the method of fractionation adopted and in subsequent papers to deal in more detail with the character of the isolated complexes.
Journal of Bone and Joint Surgery - British VolumeEXPERIMENTAL COMPARISON OF LIVING AND DEAD BONE IN RATS
15 Citations1965Jack Stevens, Robert D. Ray
The dead bone became progressively less dense than the living bone as the duration of the implantation increased, and the change in density was related to the quantity, but not to the quality, of the bone tissue examined.
Journal of Bone and Joint Surgery - British VolumeAN EXPERIMENTAL COMPARISON OF LIVING AND DEAD BONE IN RATS, I. Physical Properties
15 Citations1962Jack Stevens, Robert D. Ray
The altered radiographic density of avascular bone seen in clinical practice is almost certainly relative unless there has been concomitant appositional new bone formation, and some other explanation must be sought for the finding that dead bone takes up significant amounts of bone-seeking isotopes in radioactive tracer studies.
The Journal of BiochemistryPHYSIOLOGICAL CHEMISTRY OF THE HARD TISSUES
3 Citations1957Yosoji Ito, Susumu Tsurufuji +1 more
