3H Dendrimer Nanoparticle Organ/Tumor Distribution
Pharmaceutical ResearchPublished 1 March 2004Open access
Shraddha S. Nigavekar, Lok Yun Sung, Mikel Llanes, Areej El‐Jawahri, Theodore S. Lawrence, Christopher W. Becker
Citations149
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Abstract
Changes in the net surface charge of polycationic PAMAMs modify their biodistribution. PSD deposition into tissues is higher than NSD, although the biodistribution trend is similar. Highest levels were found in lungs, liver, and kidney, followed by those in tumor, heart, pancreas, and spleen, while lowest levels were found in brain. These nanoparticles could have future utility as systemic biomedical delivery devices.
Keywords
Materials ScienceMedicine
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