Naloxone-reversible peripheral electroanalgesia in intact and spinal rats
European Journal of PharmacologyPublished 1 October 1977
Clifford J. Woolf, Graham D. Barrett, Duncan Mitchell, Roy A.M. Myers
Citations102
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals, and Naloxone, a narcotic antagonist, almost completely reversed this analgesia.
Abstract
Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed this analgesia. It is felt that peripheral electroanalgesia acts via the release of endogenous narcotic-like substances, the enkephalins, at spinal and supraspinal centres.
Keywords
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