Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection
New England Journal of MedicinePublished 16 May 1996Open access
George Miller, Michael O. Rigsby, Lee Heston, Elizabeth Grogan, Ren Sun, Craig E. Metroka
Citations265
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The presence of antibodies to a K SHV antigenic peptide correlates with the presence of Kaposi's sarcoma in a high-risk population and provides further evidence of an etiologic role for KSHV.
Abstract
The presence of antibodies to a KSHV antigenic peptide correlates with the presence of Kaposi's sarcoma in a high-risk population and provides further evidence of an etiologic role for KSHV.
Keywords
Medicine
Proceedings of the National Academy of SciencesElectrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
53,843 Citations1979Harry Towbin, T. Staehelin +1 more
A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.
ScienceIdentification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
5,710 Citations1994Yuan Chang, Ethel Cesarman +5 more
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
New England Journal of MedicineKaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas
2,876 Citations1995Ethel Cesarman, Yuan Chang +3 more
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas.
BloodKaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]
2,197 Citations1995Jean Soulier, L Grollet +9 more
Data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients, which is a close association with Kaposi's sarcoma.
ScienceCloning the Differences Between Two Complex Genomes
1,288 Citations1993Н. А. Лисицын, Natalya Lisitsyn +1 more
The analysis of the differences between two complex genomes holds promise for the discovery of infectious agents and probes useful for genetic studies, and may also be used for isolating probes linked to sites of genomic rearrangements.
New England Journal of MedicineDetection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV Infection
1,101 Citations1995Patrick S. Moore, Yuan Chang
The same herpesvirus-like DNA sequences are present in AIDS-associated Kaposi's sarcoma, classic Kaposi’s sarcomo, and the Kaposi' sarcoma that occurs in HIV-negative homosexual men, suggesting that all three are caused by the same infectious agent.
MMWR Morbidity and Mortality Weekly ReportKaposis sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.
1,044 Citations1981Alvin E. Friedman‐Kien, L Laubenstein +8 more
Proceedings of the National Academy of SciencesRelease of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes
950 Citations1973George Miller, Muriel B. Lipman
Marmoset blood leukocytes transformed in vitro by Epstein-Barr virus regularly release extracellular infectious Epstein- Barr virus with high titers of transforming activity.
Archives of Dermatological ResearchIdiopathisches multiples Pigmentsarkom der Haut
894 Citations1872Kaposi
Annals of Internal MedicineDisseminated Kaposi's Sarcoma in Homosexual Men
724 Citations1982Alvin E. Friedman‐Kien, LINDA J. LAUBENSTEIN +7 more
It is likely that a genetic predisposition, an acquired immunoregulatory defect, and one or more infectious agents and drugs may be involved in this epidemic of disseminated Kaposi's sarcoma in homosexual men.
DETECTION OF HERPESVIRUS-LIKE DNA SEQUENCES IN KAPOSI'S SARCOMA IN PATIENTS WITH AND THOSE WITHOUT HIV INFECTION
668 Citations1995P Atrick S. M Oore, Yuan Hang
CellButyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells
660 Citations1975Aya Leder, Philip Leder
Studies using a variety of analogues and metabolites suggest that the structural features of butyric acid are rather stringently required for induction of erythroid differentiation.
NaturePersisting oncogenic herpesvirus induced by the tumour promoter TPA
633 Citations1978Harald zur Hausen, Frank J. O’Neill +2 more
A very efficient induction of EBV and other oncogenic herpesviruses by the well established cocarcinogen and tumour promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) is reported, and some TPA-treated cells show cytopathogenic changes, including polyploidisation.
Journal of VirologyPrimary characterization of a herpesvirus agent associated with Kaposi's sarcomae
570 Citations1996Patrick S. Moore, Shou‐Jiang Gao +8 more
The agent is defined as a new human herpesvirus provisionally assigned the descriptive name KS-associated herpesv virus; its formal designation is likely to be human herpes virus 8.0, the first member of this genus known to infect humans.
BloodIn vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences
564 Citations1995Ethel Cesarman, Patrick S. Moore +4 more
Journal of VirologyPrimary structure of the herpesvirus saimiri genome
433 Citations1992Jens Albrecht, John Nicholas +8 more
Genes conserved between herpesvirus saimiri and Epstein-Barr virus show that their genomes are generally collinear, although conserved gene blocks are separated by unique genes that appear to determine the particular phenotype of these viruses.
The LancetHerpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma
383 Citations1995N. Dupin, Marc Grandadam +10 more
The results reinforce the hypothesis that an infectious agent closely related to gamma-herpesvirus is implicated in the pathogenesis of Mediterranean and AIDS-associated Kaposi's sarcoma.
VirologyInduction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate
377 Citations1979János Luka, Bengt Kallin +1 more
n-Butyrate was found to increase the number of virus producer cells to a dramatic extent in the Epstein-Barr virus-carrying P3HR-1 and B95-8 lines, raising interesting questions on the mechanism of EBV induction, and its possible relationship to the known differentiation inducing ability of n-butyrate.
TransplantationKAPOSIʼS SARCOMA IN ORGAN TRANSPLANT RECIPIENTS REPORT OF 20 CASES
347 Citations1979Israel Penn
There is an increased incidence of Kaposi's sarcoma in organ transplant recipients in whom it comprises more than 3% of all de novo neoplasms, and this variety has a bad prognosis.
Nature MedicineA role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma
308 Citations1995Martin Schalling, Marianne Ekman +3 more
It is suggested that the presence of novel, herpes virus DNA sequences in more than 90% of AIDS Kaposi lesions (AKS) would strongly suggest a specific, aetiopathological involvement of this putative new herpes virus in the pathogenesis of Kaposi's sarcoma, rather than a contamination of yet another opportunistic virus in immunosuppressed AIDS patients.
BloodMolecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus
295 Citations1989DM Knowles, Giorgio Inghirami +2 more
BloodMolecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus
255 Citations1989DM Knowles, Giorgio Inghirami +2 more
These studies demonstrate that these three AIDS-associated neoplasms of uncertain lineage exhibit a strikingly similar constellation of distinctly uncommon morphologic, immunophenotypic, and molecular genetic characteristics that distinguishes them substantially from the vast majority of NHLs that have been reported to occur in association with AIDS.
Proceedings of the National Academy of SciencesEpstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.
248 Citations1987A Calender, M Billaud +4 more
The results suggest that the immortalizing potential of EBV is correlated with its ability to induce expression of B-cell activation markers, which are suspected to play a major role in the physiological pathway leading to lymphoid cell proliferation.
International Journal of CancerKaposi's sarcoma and its relationship to cytomegalovirus (CMV) III. CMV DNA and CMV early antigens in Kaposi's sarcoma
227 Citations1980G Giraldo, E. Beth +1 more
CMV-related antigens, mainly localized in the nucleus, were found in cryostat sections of seven of 31 tumor biopsies and four of 12 KS cell lines at early passage level, indicating that the antigen is present in a high number of tumor cells, like the Epstein-Barr virus nuclear antigen in EBV-transformed cells.
Archives of Internal MedicineKaposi's Sarcoma-Associated Herpesvirus and Kaposi's Sarcoma in Africa
179 Citations1996Yuan Chang
PubMedEpidemiology of Kaposi's sarcoma.
172 Citations1991Valerie Beral
The epidemiological evidence summarized here strongly suggests that the disease is caused by a transmissible agent, in addition to HIV, and is the most important mode of transmission of the agent.
Archives of Internal MedicineKaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group
131 Citations1996Yuan Chang
As in North America and Europe, KSHV infection is strongly associated with both HIV-Seropositive and HIV-seronegative KS in Africa, however, it is likely that infection with this virus is more highly prevalent in Uganda.
The LancetHPV-16-related DNA sequences in Kaposi's sarcoma
126 Citations1992Yunxia Huang, J.J. Li +11 more
The findings suggest that HPV-16-related DNA sequences are associated with different forms of KS and may have a role in the pathogenesis of this neoplasm.
Proceedings of the National Academy of SciencesIdentification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.
114 Citations1983M S Rabson, Lee Heston +1 more
Evidence is provided that EA induction is brought about by unusual forms of EBV DNA that are likely to act by regulating expression of the genome.
Clinical Infectious DiseasesMycoplasma penetrans Infection in Male Homosexuals with AIDS: High Seroprevalence and Association with Kaposi's Sarcoma
102 Citations1993R. Y.-H. Wang, J W Shih +9 more
Antibodies to Mycoplasma penetrans were found at an unusually high frequency in male homosexuals with AIDS and in human immunodeficiency virus (HIV)-infected asymptomatic homosexuals but not in intravenous drug users and hemophiliacs with or without HIV-1 infection.
Journal of VirologyGene mapping and expression of two immunodominant Epstein-Barr virus capsid proteins
58 Citations1993W M van Grunsven, Erika C. van Heerde +3 more
Complete inhibition of viral DNA polymerase activity by phosphonoacetic acid is associated with the absence of RNAs and protein products of both ORFs, indicating that VCA-p18 and V CA-p40 are true late antigens.
BloodButyrate induces selective transcriptional activation of a hypomethylated embryonic globin gene in adult erythroid cells
47 Citations1988Burns Lj, JG Glauber +1 more
It is shown that demethylation by 5-azacytidine is a prerequisite but not sufficient cis-regulatory event for a high level of transcriptional activation of the embryonic rho-globin gene in adult erythroid cells in vivo.
The Journal of Infectious DiseasesLack of Association of Cytomegalovirus with Endemic African Kaposi's Sarcoma
42 Citations1987R. F. Ambinder, Christy E. Newman +9 more
11. Rao CR.
Archives of Internal MedicineRisk Factors for Kaposi's Sarcoma in Patients With Advanced Human Immunodeficiency Virus Disease Treated With Zidovudine
24 Citations1994Joel E. Gallant
This large cohort study provides further evidence for an association between risk for cytomegalovirus infection and KS, especially among male homosexuals.
Archives of Internal MedicineRisk factors for Kaposi's sarcoma in patients with advanced human immunodeficiency virus disease treated with zidovudine. Zidovudine Epidemiology Study Group
24 Citations1994Joel E. Gallant
This large cohort study provides further evidence for an association between risk for cytomegalovirus infection and KS, especially among male homosexuals.
AIDS Research and Human RetrovirusesAnalysis of Human KS Biopsies and Cloned Cell Lines for Cytomegalovims, HIV-1, and Other Selected DNA Virus Sequences
19 Citations1989Nazma Jahan, Abdur Razzaque +5 more
Nucleic acid hybridization analysis of both KS biopsies from AIDS patients as well as cloned KS endothelial cell lines for HCMV mtrII sequences was focused on, since these viruses have also been implicated in the etiology of KS.