Hypothesis: does breast cancer originate in utero?
The LancetPublished 1 April 1990
D Trichopoulos
Citations464
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The existing empirical data seem to be compatible with the hypothesis that increased concentrations of oestrogens in pregnancy increase the probability of future occurrence of breast cancer in daughters.
Abstract
Factors that increase the risk of cancer during adult life may also increase the risk of cancer when they act in utero (eg, ionising radiation and diethylstilboestrol in human beings and chemicals in animals). The existing empirical data seem to be compatible with the hypothesis that increased concentrations of oestrogens in pregnancy increase the probability of future occurrence of breast cancer in daughters.
Keywords
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