Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease
Journal of Vascular SurgeryPublished 1 February 1998Open access
Samuel R. Money, J. Alan Herd, Jonathan L. Isaacsohn, Michael Davidson, Bruce S. Cutler, Jeffrey Heckman
Citations337
SJR quartileQ1
SJR score2.08
SNIP2.00
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TL;DR
Cilostazol significantly increased ACD at all measured time points and initial claudication distances at most time points, suggesting this agent may represent a new treatment option for patients with intermittentClaudication.
Abstract
Cilostazol significantly increased ACD at all measured time points and initial claudication distances at most time points. This agent may represent a new treatment option for patients with intermittent claudication.
Keywords
Medicine
CirculationThe prevalence of peripheral arterial disease in a defined population.
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CirculationCilostazol Has Beneficial Effects in Treatment of Intermittent Claudication
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Cilostazol improved walking distances, significantly increasing ICD and ACD, and patients' and physicians' subjective assessments corroborated the measured improvements in walking performance observed in the cilostrazol-treated group.
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414 Citations1982John M. Porter, Bruce S. Cutler +5 more
Pentoxifylline given orally in doses up to 1200 mg/day was significantly more effective than placebo in increasing both the initial and absolute claudication distances in patients with COAD.
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T treadmill training alone was more effective in improving functional status in patients with intermittent claudication than strength training or combinations of the training modalities.
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This work has summarized data from series that specifically identified claudicants without rest pain or tissue loss and natural history, epidemiology, effects of diabetes and smoking, outcome prediction factors, and miscellaneous asDects of intermittent claudication are outlined.
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Compared PTA with supervised exercise therapy for patients with arterial occlusive disease judged suitable for PTA at angiography, mean ABPI were significantly improved at 3, 6 and 9 months without a corresponding significant increase in mean maximum walking distances.
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220 Citations1985Yukio Kimura, T Tani +2 more
The drug potently prevented death due to pulmonary thrombosis by platelet aggregates in mice in vivo and cilostazol is a promising antithrombotic drug.
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204 Citations1997Robert B. Patterson, Bernardine M. Pinto +4 more
Although a supervised program results in optimal walking benefits, a highly structured home-based program provides similar functional improvement and may be a satisfactory alternative for patients with lesser walking requirements.
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It is concluded that vascular laboratory tests provide a useful, and objective means of determining the prevalence of PAD in a geographically-based population of diabetic and control subjects.
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More work is required to document the natural history of the disease, the risk factors for its progression, its relationship with cardiovascular disease, and the effect of intervention strategies.
The Journal of Clinical PharmacologyAnother Look at the Pentoxifylline Efficacy Data for Intermittent Claudication
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The reanalysis of the Porter et al data by "intention to treat" and by use of the minimum-distance-walked measure confirms the published findings of efficacy of pentoxifylline for treatment of intermittent claudication.
AngiologyCurrent Therapy of Peripheral Obstructive Arterial Disease. The Non-Surgical Approach
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In conclusion the many controlled clinical trials carried out over the past few years have clearly demonstrated that conservative treatment can alleviate clinical signs and symptoms in patients with claudication and pain at rest.
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Appropriate allocation of resources to detect and treat vascular disease demands that clinicians not only assume responsibility for the care of individual patients but also develop a working knowledge of the clinical epidemiology of vascular health and disease and its management within populations.
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Initial conservative treatment emphasizing abstinence from tobacco products, control of underlying medical maladies, and an exercise program, along with patient reassurance, will adequately treat the majority of claudicators.