Mechanisms of Human Lymphocyte Migration and their Role in the Pathogenesis of Disease
Immunological ReviewsPublished 1 April 1989
Steven T. Pals, E. van der Horst, Rik J. Scheper, Chris J.L.M. Meijer
Citations93
SJR quartileQ1
SJR score3.30
SNIP1.60
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TL;DR
Evidence indicating that adhesive interactions between recirculating lymphocytes and the wall of high endothelial venules (HEV) are thought to play a central role in the pathogenesis of chronic inflammatory diseases and non-Hodgkin's lymphomas is discussed.
Abstract
Lymphocyte recirculation is an essential component of the functional immune system, providing a means for constant surveillance of the organism's tissues by immunocompetent cells and, moreover, facilitating interactions between different cell types engaged in the immune response. Adhesive interactions between recirculating lymphocytes and the wall of high endothelial venules (HEV) are thought to play a central role in this process. These interactions are mediated by lymphocyte homing receptors expressed on the lymphocyte cell surface which recognize tissue-specific molecules on the endothelium. Moreover, LFA-1 is also involved in the regulation of lymphocyte traffic. In addition, recent evidence indicating that these mechanisms may also play a role in the pathogenesis of chronic inflammatory diseases and non-Hodgkin's lymphomas is discussed.
Keywords
Immunology and MicrobiologyMedicine
The Journal of ImmunologyInduction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
2,471 Citations1986Michael L. Dustin, Robert Rothlein +3 more
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NatureA cell-surface molecule involved in organ-specific homing of lymphocytes
1,492 Citations1983W. Michael Gallatin, Irving L. Weissman +1 more
A monoclonal antibody specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV and to be required for lymphocyte homing into lymph nodes in vivo is described.
Proceedings of the Royal Society of London. Series B, Biological sciencesThe route of re-circulation of lymphocytes in the rat
1,452 Citations1964J. L. Gowans, Emma Knight
It was concluded that the re-circulating pool of small lymphocytes was located in the lymphoid tissue, the thymus excepted, and that the rapid ‘homing’ of cells into the lymph nodes had its basis in the special affinity ofsmall lymphocytes for the endothelium of the post-capillary venules.
Annual Review of MedicineLEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins
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Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
Annual Review of ImmunologyThe Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System
1,103 Citations1987Timothy A. Springer, Michael L. Dustin +2 more
This review focuses on LFAI, CD2, and LFA-3, which appear to enhance antigen-specific functions by acting as cell adhesion molecules and the role of CD4 and CD8 is reviewed by Littman.
NatureA tissue-specific endothelial cell molecule involved in lymphocyte homing
720 Citations1988Philip R. Streeter, Ellen L. Berg +3 more
An endothelial cell surface molecule that is selectively expressed in mucosal organs is required for lymphocyte homing to mucosal lymphoid tissues and appears to function as a tissue-specific marker or address signal for recognition by lymphocytes circulating in the blood.
The Journal of Experimental MedicineLymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.
678 Citations1976Hugh B. Stamper, Judith J. Woodruff
Evidence is presented that adherence to HEV in vitro is a property of recirculating lymphocytes and not a characteristic of cells which are unable to home into lymph nodes in vivo.
The Journal of Cell BiologyImmunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.
639 Citations1988Philip R. Streeter, B T Rouse +1 more
MECA-79 defines a novel vascular addressin involved in directing lymphocyte homing to peripheral lymph nodes and blocks binding of both normal lymphocytes and a peripheral lymph node-specific lymphoma to peripheralymph node HEV in vitro and in vivo.
NatureICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells
579 Citations1988Malegapuru W. Makgoba, Martin E. Sanders +6 more
The Journal of Cell BiologyLymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.
543 Citations1987Sirpa Jalkanen, Robert F. Bargatze +2 more
It is shown that antibodies capable of inhibiting human lymphocyte binding to one or more HEV types recognize a common 85- 95-kD lymphocyte surface glycoprotein antigen, defined by the non- blocking monoclonal antibody, Hermes-1, which implies that related molecular mechanisms are involved in several functionally independent cell-cell recognition events that direct lymphocyte traffic.
Proceedings of the Royal Society of London. Series B, Biological sciencesThe migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study
505 Citations1964Vincent T. Marchesi, J. L. Gowans
The evidence suggests that these venules are normally the site of a large-scale migration of lymphocytes from the blood into the lymph nodes of rats, and that in inflamed lymph nodes polymorphs and monocytes emigrate through the venules by penetrating the junctions between endothelial cells.
European Journal of ImmunologyA lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man
427 Citations1986Sirpa Jalkanen, Robert F. Bargatze +2 more
It is demonstrated that the molecule defined by Hermes‐1 either functions as a specific lymphocyte surface receptor for HEV, or is both precisely coregulated and physically and/or functionally associated with such receptors.
The Journal of ImmunologyLeukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.
409 Citations1987David Lewinsohn, Robert F. Bargatze +1 more
It is proposed that receptors for tissue-specific endothelial determinants are utilized by neutrophils and lymphocytes and probably other leukocytes during the physiologic process of leukocyte extravasation in vivo.
European Journal of ImmunologyThe gut‐associated lymphoid system: nature and properties of the large dividing cells
389 Citations1974Delphine Guy‐Grand, C Griscelli +1 more
B and T blasts from MLN and TDL have, in contrast to blasts from the peripheral lymph nodes, a marked tendancy to home in the gut, and migrate as well in a graft of fetal intestine as in the recipient's own gut, indicating that this selective accumulation is not the result of a mechanism recognizing antigen absorbed from the gut lumen.
Immunology TodayAdhesive protein receptors on hematopoietic cells
347 Citations1988Martin E. Hemler
Analysis of newly discovered receptor structures involved in cell-matrix adhesion suggest that hematopoietic cells have a wealth of new and diverse functions involving interactions with extracellular matrix.
European Journal of ImmunologyOrgan specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ‐specific determinants on high endothelial venules
343 Citations1980Eugene C. Butcher, Roland Scollay +1 more
It is proposed that lymphocyte surface receptors specific for organ‐restricted endothelial cell determinants mediate the antigen‐independent organ specificity of lymphocyte migration.
ScienceA Distinct Endothelial Cell Recognition System That Controls Lymphocyte Traffic into Inflamed Synovium
312 Citations1986Sirpa Jalkanen, Allen C. Steere +2 more
It is suggested that a lymphocyte-endothelial cell recognition system that is distinct from such systems in organized lymphoid tissues directs the extravasation of normal lymphocytes as well as pathologically important effector cells into inflamed synovium.
The Journal of ImmunologyEvidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.
304 Citations1988Alf Hamann, Dorothee Jablonski‐Westrich +5 more
It is suggested that LFA-1 plays an accessory role in cellular interactions relevant for lymphocyte migration by supporting the model of L FA-1 being an accessory mechanism strengthening weak interactions between cells.
Current topics in microbiology and immunologyThe Regulation of Lymphocyte Traffic
279 Citations1986Eugene C. Butcher
The distribution of lymphocyte populations among the tissues of the body is not random: both the number and the representation of particular functional subsets of lymphocytes are carefully controlled, differing in each lymphoid organ or tissue in a manner that presumably reflects local immune requirements.
The Journal of Experimental MedicineIDENTIFICATION OF MARROW-DERIVED AND THYMUS-DERIVED SMALL LYMPHOCYTES IN THE LYMPHOID TISSUE AND THORACIC DUCT LYMPH OF NORMAL RATS
265 Citations1972Jonathan C. Howard, Simon V. Hunt +1 more
It is shown that small lymphocytes from the thoracic duct of rats are normally a mixture of thymus-derived and marrow-derived cells, and define the traffic areas in lymphoid tissues through which the two populations recirculate, andificially reconstituted mixtures of marrow- derived and thymUS-derived lymphocytes were qualitatively indistinguishable from normal lymphocyte populations.
Immunological ReviewsHoming Receptors and the Control of Lymphocyte Migration
264 Citations1986S. Jalkantn, Roger A. Reichert +4 more
Lilyocyte homing receptors are members of a family of glycoprotein receptors for endothelium that control the extravasation of lymphocytes as well as other leukocytes, and help regulate both non-specific and specific immune responses in vivo.
The Journal of ImmunologyDifferences in the migration of B and T lymphocytes: organ-selective localization <i>in vivo</i> and the role of lymphocyte-endothelial cell recognition.
256 Citations1982S K Stevens, I L Weissman +1 more
Comparison of these homing preferences with the distribution of B and T lymphocyte populations in situ suggests that selective lymphocyte migration may help determine the proportions of functionally distinct lymphocyte classes in particular lymphoid organs or sites of chronic inflammation, and thus may serve to influence the character of local immune responses.
PubMedSpecificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo.
253 Citations1987Robert Auerbach, Wei Lu +4 more
The hypothesis that endothelial cell surface-associated specificities may play a significant role in determining the pattern of metastasis in mouse tumor cells is supported.
The Journal of ImmunologyBiochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man.
249 Citations1988Sirpa Jalkanen, Markku Jalkanen +3 more
A subset of the Hermes-1-immunoprecipitated species is modified by covalent linkage to chondroitin sulfate, yielding a Mr of approximately 180 to 200 kDa, which appears to be processed either to the 85- to 95-kDa form or to a 180- to 200- kDa form.
The Journal of ImmunologyT lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.
245 Citations1986Dorian O. Haskard, Druie Cavender +3 more
The results suggest that the mechanism of binding of lymphocytes to unstimulated endothelium differs from that to stimulated endothelia, and LFA-1 appears to be an important adhesion-related molecule for binding to unstIMulated endot Helium.
ScienceInvolvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation
235 Citations1985Steven D. Rosen, Mark S. Singer +2 more
Mouse lymphocytes incubated on cryostat-cut sections of lymphoid organs suggest that sialic acid on endothelial cells may be an organ-specific recognition determinant for lymphocyte attachment.
The Journal of Experimental MedicineTHE DISTRIBUTION OF LARGE DIVIDING LYMPH NODE CELLS IN SYNGENEIC RECIPIENT RATS AFTER INTRAVENOUS INJECTION
222 Citations1969C Griscelli, P Vassalli +1 more
The distribution of large dividing lymph node or thoracic duct lymph cells, labeled in vitro with 3H-thymidine, was studied in syngeneic recipient rats after intravenous injection and found that the labeled cells rapidly "homed" to lymphoid tissue and recirculated in the recipient, in a fashion resembling that of small lymphocytes.
Human ImmunologyLFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes
221 Citations1987Eric Martz
There is scanty evidence in support of indirect "negative signals" that may be induced by such antibodies, and direct participation of most LFAs in adhesion seems likely, but at least some of these mechanisms are widely used among cells of hematopoietic origin.
The Journal of Experimental MedicineTwo distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes.
212 Citations1977Ross N. P. Cahill, David C. Poskitt +2 more
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208 Citations1988Michael L. Dustin, Donald E. Staunton +1 more
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PubMedHigh endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452.
207 Citations1988A. M. Duijvestijn, E Horst +6 more
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The Journal of Experimental MedicineThe effects of antigen on the migration of recirculating lymphocytes through single lymph nodes.
206 Citations1976Ross N. P. Cahill, Heiner Frost +1 more
The increased input of RL into LN starts within 3 h after antigenic stimulation and is due to an increase in the number of RL passing through a LN and the decreased cell output from the LN can occur independently and are possibly controlled by different mechanisms.
The Journal of ImmunologyStimulation of endothelial cell binding of lymphocytes by tumor necrosis factor.
195 Citations1987Druie Cavender, Yasuhiro Saegusa +1 more
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The Journal of Experimental MedicineTHE MIGRATION OF LYMPHOCYTES ACROSS THE VASCULAR ENDOTHELIUM IN LYMPHOID TISSUE
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An electron microscope study of the mode of lymphocyte migration across the endothelial layer of venules in the Peyer's patches of mice and rats concluded that lymphocytes migrate across the vascular endothelium by insinuating themselves between endothelial cells and not by passing through them.
The Journal of Experimental MedicineTHE ULTRASTRUCTURE AND FUNCTION OF THE CELLS IN LYMPH FOLLOWING ANTIGENIC STIMULATION
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It was concluded that these basophilic cells rather than antigen are responsible for propagating the immune response throughout the body and that they depend on an intact lymphatic pathway for their immediate transport.
The Journal of Cell BiologyReceptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen.
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PubMedStudies on the structure and permeability of the microvasculature in normal rat lymph nodes.
159 Citations1975Arthur O. Anderson, Norman D. Anderson
The structure and permeability of the microvasculature in normal rat lymph nodes was studied by regional perfusion techniques and indicated that characteristic vascular units supplied each cortical lobule of lymphatic tissue.
The Journal of Experimental MedicineGerminal center B cells lack homing receptors necessary for normal lymphocyte recirculation.
155 Citations1983Roger A. Reichert, W M Gallatin +2 more
Migratory and endothelial-recognition properties of GCLC, when viewed in the context of the possible role of these cells as precursors of plasma cells and/or memory B cells, have led us to propose that the inability of GclC to recognize HEV may be transient and related to a phase of sessile B cell differentiation.
European Journal of ImmunologyStudies on the lymphocytes of sheep. Destination of lymph‐borne immunoblasts in relation to their tissue of origin
154 Citations1977Judith G. Hall, John Hopkins +1 more
Proceedings of the National Academy of SciencesInterferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic.
143 Citations1986A. M. Duijvestijn, Alain B. Schreiber +1 more
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European Journal of ImmunologyDisappearance and reappearance of high endothelial venules and immigrating lymphocytes in lymph nodes deprived of afferent lymphatic vessels: a possible regulatory role of macrophages in lymphocyte migration
142 Citations1983Hans R. Hendriks, I.L. Eestermans
Interruption of the afferent lymphatic vessels of the popliteal lymph node resulted in the disappearance of high endothelial venules (HEV) and immigrating lymphocytes within 3 weeks and the number of macrophages in the lymph node was severely reduced.
The Journal of ImmunologyEvidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules.
115 Citations1988Steven T. Pals, Annelies den Otter +5 more
Results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.
PubMedSpecialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues.
112 Citations1976Norman D. Anderson, Arthur O. Anderson +1 more
Characteristics of high endothelial venules (HEV) in rat lymphatic tissues were defined to facilitate lymphocyte entry into the node and minimized vascular leakge.
The Journal of Cell BiologyInvolvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants.
110 Citations1989F. F. Roossien, D de Rijk +2 more
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GastroenterologyA comparison of lymphocyte migration through intestinal lymph nodes, subcutaneous lymph nodes, and chronic inflammatory sites of sheep
110 Citations1980Warren Chin, John B. Hay
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The Journal of ImmunologyLymphocyte recognition of lymph node high endothelium. VII. Cell surface proteins involved in adhesion defined by monoclonal anti-HEBFLN (A.11) antibody.
106 Citations1985R. A. Rasmussen, Y H Chin +2 more
The Journal of Experimental MedicineHigh endothelial venule binding as a predictor of the dissemination of passaged murine lymphomas.
106 Citations1987Robert F. Bargatze, N W Wu +2 more
The results suggest that the expression of functional receptors for HEV either controls the hematogenous dissemination of malignant lymphocyte populations to HEV-bearing organs, or is coregulated with factors determining this metastatic behavior.
Proceedings of the National Academy of SciencesDifferential adhesion of tumor cells to capillary endothelial cells in vitro.
106 Citations1984L. J. Alby, R. Auerbach
The experiments demonstrate that capillary endothelial cells derived from different sources are not alike and that differences expressed at the cell surface of these cells can be distinguished by tumor cells.
The Journal of ImmunologyDifferences in in vivo distribution and homing of T cell subsets to mucosal vs nonmucosal lymphoid organs.
99 Citations1983Georg Kraal, I L Weissman +1 more
The homing and HEV recognition preferences of the Lyt subsets are reflected in differences in their in situ representation in mucosal vs nonmucosal lymphoid organs, which suggests that the selective migration of these populations may be an important factor in determining the character of local immune responses.
ScienceDynamics of Lymphocyte-Endothelial Interactions in Vivo
99 Citations1986Matthew Bjerknes, Hazel Cheng +1 more
The dynamics of the attachment of lymphocytes to the endothelium of high endothelial venules in murine Peyer's patches were studied in vivo and many lymphocytes experienced multiple collisions with the high vascular venules, which substantially increased the efficiency of lymphocyte collection by these vessels.
BloodHoming receptors on human and rodent lymphocytes--evidence for a conserved carbohydrate-binding specificity
95 Citations1987LM Stoolman, T A Yednock +1 more
It is argued that the close functional relationship between the human and rodent receptors indicates that this component of the adhesive interaction has been conserved through evolution.
BloodIn vitro analysis of the homing properties of human lymphocytes: developmental regulation of functional receptors for high endothelial venules
95 Citations1985ST Jalkanen, E C Butcher
The Journal of ImmunologyIdentification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor.
94 Citations1989Steven T. Pals, Frans B.L. Hogervorst +4 more
Results indicate that the 90-kDa glycoprotein homologues of the Hermes-1 human lymphocyte homing receptor are expressed on hemopoietic tissues as well as on a number of nonhemopoetic tissues and tumor cell lines.
GutDendritic cells and scavenger macrophages in chronic inflammatory bowel disease.
89 Citations1989Cornelis A. Seldenrijk, H. A. Drexhage +3 more
The observation that scavenger macrophages were localised more superficial, as band like zones can be taken as evidence that at these spots the ingestion and degradation of foreign material takes place.
The Journal of ImmunologyRegulation of lymphocyte homing. I. Alterations in homing receptor expression and organ-specific high endothelial venule binding of lymphocytes upon activation.
88 Citations1988Alf Hamann, Dorothee Jablonski‐Westrich +4 more
Functional assays reveal that Con A and periodate stimulation lead to a selective, nearly complete suppression of the lymphocytes binding to HEV of Peyer's patches, even under conditions where overall binding to peripheral node HEV is increased.
PubMedExpression of lymphocyte homing receptor antigen in non-Hodgkin's lymphoma.
84 Citations1988Louis J. Picker, L. Jeffrey Medeiros +3 more
The results indicate that homing receptor antigen expression, although perhaps necessary for wide-spread blood-borne lymphoma dissemination to lymphoid sites, is not in and of itself sufficient to predict such behavior in this subtype of lymphoid malignancy.
American Journal of AnatomyThe mode of lymphocyte migration through postcapillary venule endothelium in lymph node
83 Citations1975Andrew G. Farr, Peter P. H. De Bruyn
The pathway of migration of lymphocytes across the walls of the postcapillary venules was studied in lymph nodes of rats and it was determined that lymphocytes enter the venule wall through the endothelial cells and not through the intercellular spaces.
European Journal of ImmunologyRapid decrease in lymphocyte adherence to high endothelial venules in lymph nodes deprived of afferent lymphatic vessels
70 Citations1987Hans R. Hendriks, Adrian M. Duijvestijn +1 more
In the present study the in vitro lymphocyte‐binding assay was used to investigate the ability of HEV in rat LN to bind lymphocytes at various time points after occlusion of the afferent lymph flow.
The Journal of Clinical Endocrinology & MetabolismHigh Endothelial Venules Present in Lymphoid Cell Accumulations in Thyroids Affected by Autoimmune Disease: A Study in Men and BB Rats of Functional Activity and Development*
68 Citations1989Peter Kabel, Hieronymus A.M. Voorbij +3 more
Investigation of the immunohistochemical presence and localization of HEVs in thyroid tissue obtained at surgery from 13 patients with Graves' disease and 3 patients with Hashimoto's disease using the monoclonal antibody HECA 452 concludes that lymphoid tissue with a lymphocyte recirculation pattern similar to that of mucosa-associated lymphoids tissue can be found in thyroid glands involved in a process of autoimmune reactivity.
Annual Review of MedicineLeukocyte Adhesion Deficiency: An Inherited Defect In The Mac-1, LFA-1, And p150,95 Glycoproteins
68 Citations1987David C. Anderson
The Journal of PathologyFunctional and morphological changes in post‐capillary venules in relation to lymphocytic infiltration into BCG‐induced granulomata in rat skin
67 Citations1985Anthony J. Freemont, William L. Ford
By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV‐like vessels have been shown to be the preferred site of migration.
The Journal of Cell BiologyEvolutionary conservation of tissue-specific lymphocyte-endothelial cell recognition mechanisms involved in lymphocyte homing.
67 Citations1988N W Wu, Sirpa Jalkanen +2 more
An in vitro assay of lymphocyte binding to HEV in frozen sections of lymphoid tissues confirms that mouse, guinea pig, and human lymphocytes bind to xenogeneic as well as homologous HEV, and shows that mouse andhuman lymphoid cell lines that bind selectively to either peripheral lymph node or mucosal vessels inhomologous lymphoid tissue exhibit the same organ specificity in binding to xenogenicic HEV.
Journal of Cell ScienceMigration of lymphocytes across specialized vascular endothelium : V. Production of a sulphated macromolecule by high endothelial cells in lymph nodes*
66 Citations1982Paul Andrews, DAVID W. MILSOM +1 more
High endothelial cells lining the post capillary venules in the paracortical areas of rat lymph nodes were found by autoradiography to incorporate [35S]sulphate, whether it was injected into the footpad to reach the draining popliteal lymph node or added to short-term cultures of cervical lymph node slices.
The Journal of ImmunologyLymphocyte recognition of lymph node high endothelium. VI. Evidence of distinct structures mediating binding to high endothelial cells of lymph nodes and Peyer's patches.
66 Citations1984Y H Chin, R. A. Rasmussen +2 more
The results demonstrate the existence of two antigenically distinct species of HEBF and imply that lymphocyte binding sites of HEVLN and HEVPP are structurally different, and mean that distinct high endothelial adhesion molecules on lymphocytes mediate their entry into LN and PP.
NaturePossible role of surface Ig in non-random recirculation of small lymphocytes
65 Citations1976Roland Scollay, John Hopkins +1 more
By comparing the recirculation of small lymphocytes from the intestinal lymph with that of lymphocyte from the efferent lymph of PSLNs in unanaesthetised sheep, it is found that each population tends to recirculate preferentially through the type of lymphoid tissue from which the collections were made.
European Journal of ImmunologyInteraction between lymphocytes and cultured high endothelial cells: an in vitro model of lymphocyte migration across high endothelial venule endothelium
60 Citations1988Ann Ager, Shilaben Mistry
The interaction between lymphocytes and cultured high endothelial venule endothelium has been studied using light and electron microscopy and suggested that lymphocytes actively migrated across the HEC layer in this assay.
Cell and Tissue ResearchDepletion of macrophages and disappearance of postcapillary high endothelial venules in lymph nodes deprived of afferent lymphatic vessels
58 Citations1980Hans R. Hendriks, I.L. Eestermans +1 more
The afferent lymphatic vessels of rat popliteal lymph nodes were interrupted, and the histological alterations in the lymph nodes occurring 1 to 14 weeks after operation were studied.
Journal of Clinical PathologyA possible route for lymphocyte migration into diseased tissues
54 Citations1983Anthony J. Freemont
Undescribed venules have been identified within lymphocyte aggregates which exhibit a structure, ultrastructure and cytochemistry previously believed to be restricted to the high endothelial venules of lymphoid tissues.
PubMedT-cell recirculation in the sheep: migratory properties of cells from lymph nodes.
53 Citations1982John D. Reynolds, Iver Heron +2 more
There are differences in the composition of the T-cell population in a node compared with that of the lymph draining the node, and this phenomenon was much less evident with T cells from mesenteric nodes and prescapular nodes and in a number of experiments a random pattern of recirculation occurred.
The Journal of ImmunologyHuman lymphocyte-high endothelial venule interaction: organ-selective binding of T and B lymphocyte populations to high endothelium.
53 Citations1986Steven T. Pals, G. Kraal +4 more
The findings indicate that organ--specific lymphocyte-endothelial cell recognition mechanisms exist also in humans, and suggest that these mechanisms play an important role in normal and pathologic lymphocyte traffic.
ImmunobiologyAfferent Lymph and Lymph Borne Cells: Their Influence on Lymph Node Function
52 Citations1984Mark T. Drayson, W. L. Ford
In conclusion the involution of the deafferentized LN is partly due to the lack of antigen but progression to the complete loss of specialized structure and function is probably due to lack of other factors including non-lymphoid cells that normally arrive in afferent lymph.
The Journal of Cell BiologyInvolvement of leukocyte function-associated antigen-1 (LFA-1) in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells.
52 Citations1987Ed Roos, F. F. Roossien
The interaction of MB6A lymphoma and TAM2D2 T cell hybridoma cells with hepatocyte cultures as an in vitro model for in vivo liver invasion by these tumor cells was studied to suggest that LFA-1 is involved in the formation of liver metastases by lymphoma cells.
The Anatomical RecordBlood vessels of the Peyer's patch in the mouse: III. High‐endothelium venules
44 Citations1983Kazuhito Yamaguchi, G. I. Schoefl
NatureEvidence of continuous evolutionary change in structures mediating adherence of lymphocytes to specialised venules
44 Citations1979Eugene C. Butcher, Roland Scollay +1 more
The ability of lymphocytes from different vertebrate species to recognise specifically and bind toHEV in the mouse declines exponentially with increasing evolutionary separation of the lymphocyte donor from the mouse host, suggesting that, in spite of conservation of the functional interaction in all mammalian species examined, the cell-surface structures mediating lymphocyte adherence to HEV have been continuously and randomly altered during evolution.
Immunological ReviewsLymphocyte Migration and Differentiation in a Large‐Animal Model: The Sheep
44 Citations1986Masayuki Miyasaka, Zdeněk Trnka
The sheep is a useful animal model to study physiological events taking place in the lymphoid system, and in vivo studies in this species will continue to offer a great potential for research of biological relevance and supplement the research done on the in vitro manipulation of cells and biological products related to the immune system.
American Journal of AnatomyLight and electron microscopic studies of postcapillary venules in developing human fetal lymph nodes
38 Citations1975Raymond P. Bailey, Leon Weiss
It is suggested that the lymphocytes that first appear in developing nodes, and the majority of the lymphocyte found in late nodes, migrate to the node via the blood vascular system and enter the nodal parenchyma by passing across PCV endothelium.
The Journal of PathologyFunctional and biosynthetic changes in endothelial cells of vessels in chronically inflamed tissues: Evidence for endothelial control of lymphocyte entry into diseased tissues
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In vitro lymphocyte adhesion to, and selective radiosulphate uptake by, endothelial cells has been demonstrated in chronically inflamed tissues of patients with peptic ulceration, rheumatoid disease, pilonidal sinus, autoimmune thyroiditis, polymyositis, primary biliary cirrhosis, and pyelonephritis, suggesting that some vessels in inflamed tissue may be responsible for the selective accumulation of lymphocytes within the tissue.
Experimental Cell BiologyThe Endothelium of the High Endothelial Venule: A Specialized Endothelium with Unique Properties
32 Citations2008Georg Kraal, Adrian M. Duijvestijn +1 more
Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local micro-environments.
PubMedReassortment of lymphocytes in lymph from normal and allografted sheep.
30 Citations1977H. R. P. Miller, E.P. Adams
The differences between central lymph and peripheral lymph from both normal and graft-bearing sheep are thought to reflect a restriction on the passage of SIg cells through capillary endothelium in nonlymphoid tissues.
PubMedIndividual epitopes of an 85,000 MW membrane adherence molecule are variably expressed on cells of different lineage.
16 Citations1988Thomas F. Schulz, Werner Vogetseder +4 more
The results indicate that the 7F7 antigen and the P3.58 melanoma antigen are identical, that some epitopes of this adherence molecule are differentially expressed on individual cell types and that one epitope, which is only weakly expressed on activated T cells, does not contribute to the role of the 7f7 antigen in some examples of cell-cell adherence.
Novartis Foundation symposiumLymphocyte Recirculation in the Sheep Fetus
14 Citations1980Ross N. P. Cahill, Iver Heron +2 more
The circulation of lymphocytes through the spleen and lymph nodes of fetal lambs was more intense than in the adult, indicating that the pathways of recirculation and the capacity of cells to recirculate arise as a physiological process independently of antigenic stimulation.
Advances in experimental medicine and biologyReversibility of Loss of Homing Receptor Expression Following Activation
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Recirculation and homing to lymph nodes and Peyer's patches is initiated by the binding of cells to specialized post-capillary high endothelial venules (HEV’s), followed by their passage through the vessel walls into the surrounding lymphoid tissue.
Advances in experimental medicine and biologyExpression and Regulation of an Antigen Specific for Endothelium Involved in Human Lymphocyte Homing
7 Citations1988E. van der Horst, Steven T. Pals +5 more
The presence of HEV are normally present in the paracortex of lymph nodes and mucosa associated lymphoid tissues, moreover vessels with HEV-like morphology can arise at sites of inflammation.
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