Asthma due to inhaled chemical agents—tolylene di‐isocyanate
Clinical & Experimental AllergyPublished 1 September 1972
J. Pepys, Christopher Pickering, A. B. X. Breslin, Dave Terry
Citations110
SJR quartileQ1
SJR score1.54
SNIP1.34
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TL;DR
The possibility of sensitization in conditions of limited exposure requires more frequent consideration as none of the four subjects tested gave histories of heavy exposure.
Abstract
Summary Four patients with asthma due to tolylene di‐isocyanate (TDI) were tested by occupational type exposure to a polyurethane varnish and its TDI activator'. Late asthmatic reactions were given in two patients, the third gave an immediate reaction and the fourth gave a dual, immediate followed by late asthmatic, reaction. The reactions in the last two patients were inhibited by disodium cromoglycate. Two patients encountered the TDI in fumes from soldering polyurethane coated wire. The possibility of sensitization in conditions of limited exposure requires more frequent consideration as none of the four subjects tested gave histories of heavy exposure.
Keywords
MedicineHealth Professions
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The isocyanate group is chemically highly reactive, and diisocyanates will combine with many organic compounds to form high-molecular-weight polymer of the polyurethane type, which is used as paints and varnishes, surface coatings, flexible and rigid foams in upholstery and soft toys, and in sound insulation.
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