Tables of the number of patients required in clinical trials using the logrank test

Statistics in MedicinePublished 1 January 1982

Laurence S. Freedman

DOI10.1002/sim.4780010204

Source URL

Citations725

SJR quartileQ1

SJR score1.27

SNIP1.33

TL;DR

The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer and the numbers required are considerably smaller than those in existing tables when the event-free proportions are small, but otherwise comparable.

Abstract

The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event-free proportions are small, but otherwise comparable.

Keywords

Computer ScienceMathematics

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