Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients
The LancetPublished 1 October 1995
Jarmo Hietala, J. Hietala, Erkka Syvälahti, Mikko Kuoppamäki, J. Hietala, J. Hietala
Citations322
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Alterations in striatal presynaptic dopamine function may constitute a part of disrupted neural circuits that predispose to schizophrenic psychosis.
Abstract
Presynaptic dopamine function (6-[18F]-fluorodopa uptake) in the brains of seven neuroleptic-naive first-admission schizophrenic patients and eight healthy controls was studied with positron emission tomography. The fluorodopa influx constant (Ki) in putamen was higher in the patients than in controls (average mean: 0.0149 vs 0.0129, p = 0.034). The changes in caudate were smaller but significantly lateralised to the left caudate. There was one catatonic schizophrenic patient in our sample. This patient had lower striatal Ki than any control. Alterations in striatal presynaptic dopamine function may constitute a part of disrupted neural circuits that predispose to schizophrenic psychosis.
Keywords
MedicineNeuroscience
New England Journal of MedicineAbnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia
1,179 Citations1992Martha E. Shenton, Ron Kikinis +9 more
New MRI neuroimaging techniques are used to derive volume measurements and three-dimensional reconstructions of temporal-lobe structures in vivo in 15 right-handed men with chronic schizophrenia and 15 matched controls to discover the degree of thought disorder is related to the size of the reduction in volume of the left posterior superior temporal gyrus.
Journal of Computer Assisted TomographyAccurate Three-Dimensional Registration of CT, PET, and/or MR Images of the Brain
1,104 Citations1989Charles A. Pelizzari, George T.Y. Chen +3 more
A surface matching technique has been developed to register multiple imaging scans of the brain in three dimensions, with accuracy on the order of the image pixel sizes, which provides a novel quantitative method to address the fundamental problem of relating structure to function in the brain.
New England Journal of MedicineAnatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia
1,009 Citations1990Richard L. Suddath, George W. Christison +3 more
SciencePositron Emission Tomography Reveals Elevated D <sub>2</sub> Dopamine Receptors in Drug-Naive Schizophrenics
933 Citations1986Dean F. Wong, Henry N. Wagner +15 more
Schizophrenia itself is associated with an increase in brain D2 dopamine receptor density, and the densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers.
Archives of General PsychiatryD2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic Patients
529 Citations1990Lars Farde
The hypothesis of generally elevated central D2 dopamine receptor densities in schizophrenia was not supported by the present findings, and significantly higher densities were found in the left than in the right putamen but not in the caudate nucleus.
Proceedings of the National Academy of SciencesElevated dopa decarboxylase activity in living brain of patients with psychosis.
340 Citations1994Jakob Reith, Chawki Benkelfat +8 more
An increase of the rate of metabolism of an exogenous dopa tracer in the neostriatum of a subgroup of patients with a history of psychosis is discovered, consistent with the theory that a state of psychosis arises when episodic dopamine excess is superimposed on a trait of basic dopamine deficiency in the striatum.
American Journal of PsychiatryAbsence of regional hemispheric volume asymmetries in first-episode schizophrenia
274 Citations1994Robert M. Bilder, H. Wu +6 more
The absence of normal hemispheric asymmetries suggests an anomaly in the development of laterally specialized cerebral systems in schizophrenia, and this may be associated with an initial presentation of nonparanoid psychosis.
Archives of General PsychiatryStriatal D2 Dopamine Receptor Characteristics in Neuroleptic-Naive Schizophrenic Patients Studied With Positron Emission Tomography
176 Citations1994Jarmo Hietala
There are no general changes in D2 dopamine receptor Bmax or Kd values in neuroleptic-naive schizophrenics, but there may be a subgroup of patients with aberrant striatal D 2 dopamine receptor characteristics in vivo.
The British Journal of PsychiatryD<sub>2</sub> Dopamine Receptor Binding in the Basal Ganglia of Antipsychotic-Free Schizophrenic Patients
137 Citations1994Lyn S. Pilowsky, Durval C. Costa +4 more
The results suggest that alterations in striatal D2 receptor distribution and density do occur in schizophrenia, and possibly reflect wider disruptions in prefrontal-striatal-limbic circuits.