High resolution size analysis of ADP-ribose polymers using modified DNA sequencing gels
Nucleic Acids ResearchPublished 1 January 1990Open access
Phyllis L. Panzeter, Felix R. Althaus
Citations67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A high resolution electrophoresis technique for separating and quantifying picomole quantities of polymers up to 60 residues long is presented to study the role of specific polymer size patterns in the regulation of chromatin protein function.
Abstract
Phyllis L. Panzeter, Felix R. Althaus; High resolution size analysis of ADP-ribose polymers using modified DNA sequencing gels, Nucleic Acids Research, Volume 1
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
BiochemistryCharacterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo
242 Citations1987Rafael Álvarez-González, Myron K. Jacobson
The detection of large polymers of ADp-ribose in intact cells suggests that alterations in chromatin organization effected by poly(ADP-ribosylation) may extend beyond the covalently modified proteins and very likely involve noncovalent interactions of poly( ADP- ribose) with other components of chromatin.
Journal of Biological ChemistryPoly ADP-Ribosylation of Proteins
57 Citations1989Hanspeter Naegeli, Pius Loetscher +1 more
A highly conserved polymer size pattern may constitute the molecular signal priming chromatin proteins for a role in DNA excision repair in vivo.