Symptom Profiles in Chronic Peptic Ulcer Disease
Scandinavian Journal of GastroenterologyPublished 1 January 1985
I. Sjoudin, Jan Svedlund, G. Dotevall, R. Gillberg
Citations24
SJR quartileQ2
SJR score0.69
SNIP0.56
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is concluded that a wide range of both abdominal and mental symptoms should be taken into account in the therapeutic management of peptic ulcer disease, in evaluation of clinical trials, and in studies of the natural history.
Abstract
Abdominal and mental symptoms were assessed in 103 outpatients with chronic peptic ulcer disease. Patients with present symptoms and a history of duodenal or prepyloric ulcer were included if they had no other disorder requiring treatment. A normal female population was used for comparison of mental symptoms. Besides the cardinal ulcer or acid-related symptoms, there was a high rate of indigestion and bowel dysfunction symptoms, usually associated with the irritable bowel syndrome. Mental symptoms were reported by almost all patients. Symptoms of anxiety, depression, and neurasthenia were seen significantly more often among the female patients than in the normal women. We conclude that a wide range of both abdominal and mental symptoms should be taken into account in the therapeutic management of peptic ulcer disease, in evaluation of clinical trials, and in studies of the natural history.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
American Journal of PsychiatryThe clinical application of the biopsychosocial model
3,260 Citations1980G.L. Engel
The implications of the biopsychosocial model for the study and care of a patient with an acute myocardial infarction are presented and contrasted with approaches used by adherents of the more traditional biomedical model.
Digestive Diseases and SciencesPhysiologic, psychologic, and social determinants in the etiology of duodenal ulcer
164 Citations1958I. Arthur Mirsky
The selection of individuals who are most likely to develop the syndrome in the future and the proper application of the concepts and tools of various disciplines during the premorbid state will yield such information about the precise determinants in the predisposition and precipitation of duodenal ulcer as to make it unnecessary to camouflage ignorance by dogma.
GutClinical presentation of patients with "dyspepsia". Detailed symptomatic study of 360 patients.
138 Citations1978J C Horrocks, F T de Dombal
This paper describes the clinical presentation of 360 patients suffering from "dyspepsia" at the time of their initial visit to two hospitals in Yorkshire, and suggests that clinicians have a faulty mental "database" of information with regard to the presentation of the various diseases concerned.
The LancetRAPID HEALING OF DUODENAL ULCERS WITH OMEPRAZOLE: DOUBLE-BLIND DOSE-COMPARATIVE TRIAL
138 Citations1983Sven Gustavsson, Lars Lööf +3 more
In a double-blind, dose-comparative trial, 32 patients with duodenal ulcer were assigned to receive either 20 mg/day or 60 mg/ day omeprazole for 4 weeks and one patient was withdrawn because of a pronounced rise in serum alanine aminotransferase on day 8.
Digestive Diseases and SciencesGastroduodenitis
101 Citations1980Robert H. Greenlaw, Daniel G. Sheahan +4 more
It is believed that gastroduodenitis can be symptomatic and may present with the same manifestations as peptic ulcer crater and is an independent entity or part of the spectrum of acid peptic (ulcer) disease.
PubMedPeptic ulcer disease--a heterogeneous group of disorders?
82 Citations1977Jerome I. Rotter, David L. Rimoin
Annals of Internal MedicineSymptom Diagnosis. A Mathematical Analysis of Epigastric Pain
56 Citations1963Joseph A. Rinaldo, PERRY SCHEINOK +1 more
Excerpt The process of choosing a diagnosis from subjective symptoms has not been examined in detail and the mechanism behind this mechanism is still unclear.
New England Journal of MedicineMoynihan's Disease? the Diagnosis of Duodenal Ulcer
56 Citations1974Howard M. Spiro
The clinical diagnosis of duodenal ulcer seems to have been revolutionized by advances in technology, particularly by the development of the fiber-endoscope during the past few years, yet many questions still need to be asked.
Scandinavian Journal of GastroenterologyA Diagnostic Study of Patients with Upper Abdominal Pain
47 Citations1975K.-M. Møllmann, O Bonnevie +2 more
It is concluded that a special research effort is needed to explain the complaint in this large group of patients with upper abdominal pain, and the probability of duodenal ulcer was low and that of X-ray negative dyspepsia high, if the pain was provoked by eating.
Scandinavian Journal of GastroenterologyThe Personality Pattern of Patients with Chronic Peptic Ulcer
41 Citations1983J. McIntosh, Rosamond Nasiry +3 more
The results of this study and others suggest that both gastric ulcer and duodenal ulcer are associated with the personality abnormalities of anxiety and neuroticism.
GastroenterologyA Computerized Questionnaire Analysis of Duodenal Ulcer Symptoms
39 Citations1976Richard Earlam
It was confirmed that ulcer pain occurred periodically with attacks and remissions, could be relieved by antacids, vomiting, and avoiding fatty food, but was made worse by worry.
QJMCLINICAL MANIFESTATIONS IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS, GASTRIC ULCER, AND DUODENAL ULCER
38 Citations1968F Edwards, N. F. Coghill
GutDuodenal ulcer: does pathophysiology equal aetiology?
36 Citations1983K. G. Wormsley
The epidemiological evidence can be summarised as showing a fairly strong (but not invariable) association between gastrinomas and duodenal ulcers, an association which, it is assumed, is based causally on the gastric hypersecretion evoked by the gastrinoma.
Digestive Diseases and SciencesGastric and duodenal ulcer are each many different diseases
36 Citations1981Jerome I. Rotter
It is becoming increasingly apparent that peptic ulcer is not one disease, but a genetically, etiologically, and pathogenetically heterogeneous group of diseases that share a common endpoint, an ulcer crater in those parts of the gastrointestinal tract exposed to acid and pepsin.
Digestive Diseases and SciencesAre gastric and duodenal ulcers separate diseases or do they form a continuum?
25 Citations1981R M Kirk
It is argued that separation of chronic peptic ulcers into gastric and duodenal may be artificial and confuse the search for common factors in their etiology.
Scandinavian Journal of GastroenterologyGastrin, Antral G Cells, and Gastric Acid in Secretagogue-Induced and Antihistamine-Inhibited Duodenal Ulcers
21 Citations1977Stephen N. Joffe, Julia M. Polak +5 more
Pretreatment with the antihistamine derivative, Pfizer UK-9040, decreased both basal and stimulated acid secretion, whereas plasma gastrin levels increased and the antral G-cells were emptied of gastrin.
Scandinavian Journal of GastroenterologyChronic Duodenal Ulcer and Depression
19 Citations1980D. W. Piper, D.E. Ariotti +2 more
Psychotherapy and PsychosomaticsChanging Concepts in Psychosomatic Theory I. Historical Analysis
6 Citations2010Chase Patterson Kimball
Among the remedies suggested for a reordering of thinking are a revision of linear unidirectional causative models to cyclical bidirectional models; a reformulation of two-dimensional temporal linear relationships toward three-dimensional spherical ones which overlap in time; the development of a language that bridges the psychological, social and biological.