Gene × Environment Interactions at the Serotonin Transporter Locus
Biological PsychiatryPublished 13 August 2008
Marcus R. Munafò, Caroline Durrant, Glyn Lewis, Jonathan Flint
Citations574
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
A systematic review and meta-analysis of the serotonin transporter (5-HTTLPR) polymorphic region x stressful life event (SLE) literature and investigated to what extent the main effects reported in this literature are consistent with a number of G x E hypotheses indicates that published studies are underpowered.
Abstract
Given reasonable assumptions regarding likely genetic and environmental effect sizes, our simulations indicate that published studies are underpowered. This, together with other aspects of the literature, leads us to suggest that the positive results for the 5-HTTLPR x SLE interactions in logistic regression models are compatible with chance findings.
Keywords
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