evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway
Naunyn-Schmiedeberg s Archives of PharmacologyPublished 1 January 1982
Pascal Bousquet, Josiane Feldman, Roger Bloch, Jean Schwartz
Citations110
SJR quartileQ2
SJR score0.77
SNIP0.86
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TL;DR
D,l-Baclofen increased blood pressure and heart rate when injected into the same region, but this effect was not antagonized by bicuculline, and a GABAergic system appears to modulate the cardiovascular regulation within the NTS.
Abstract
Microinjections of GABA and of the specific agonist of GABA receptors, muscimol, in the intermediate nucleus tractus solitarii (NTS) of pentobarbitone anaesthetized cats produced hypertension and tachycardia. The GABA receptor antagonist, bicuculline, had opposite effects and prevented those of muscimol. Therefore, a GABAergic system appears to modulate the cardiovascular regulation within the NTS. d,l-Baclofen also increased blood pressure and heart rate when injected into the same region, but this effect was not antagonized by bicuculline. The mechanism of this action of baclofen is discussed.
Keywords
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