Retard de croissance intra-utérin et déficit en néphrons
médecine/sciencesPublished 1 January 1993Open access
Claudie Merlet-Bénichou, Bonnie S. LeRoy, Thierry Gilbert, Martine Lelièvre-Pégorier
Citations28
SJR quartileQ4
SJR score0.14
SNIP0.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A systematic anatomical study revealed a large quantitative variation of the number of nephrons at birth in man and inborn nephron deficits were found to correlate very strongly with birth weight in the rat.
Abstract
Intrauterine growth
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
American Journal of HypertensionGlomeruli and Blood Pressure: Less of One, More the Other?
1,293 Citations1988B M Brenner, D. Linda Garcia +1 more
It is postulate that a renal abnormality that contributes to essential hypertension in the general population is a reduced number of nephrons, and congenital variability in filtration surface area may explain why only some, but not all, patients exposed to potentially injurious renal stimuli eventually manifest chronic nephropathy.
American Journal of Physiology-Renal PhysiologyNephron adaptation to renal injury or ablation
640 Citations1985Barry M. Brenner
Since dietary protein restriction blunts the need for compensatory glomerular hyperfiltration, there is neither a stimulus for nephron hypertrophy nor for enhanced tubule ion and fluid transport.
Kidney InternationalHemodynamically mediated glomerular injury and the progressive nature of kidney disease
609 Citations1983Principal discussant Barry M. Brenner
BJOG An International Journal of Obstetrics & GynaecologyThe effect of intrauterine growth retardation on the development of renal nephrons
578 Citations1992S. A. Hinchliffe, Matthew R. J. Lynch +3 more
This study aims to investigate the effect of Type II (asymmetrical) intrauterine growth retardation (IUGR) on renal development and to establish a cause and effect relationship between IUGR and renal development.
Pediatric NephrologyPrognosis of patients with unilateral renal agenesis
183 Citations1992Luis R. Argueso, Michael L. Ritchey +4 more
It is indicated that patients with unilateral renal agenesis and a normal solitary kidney are at increased risk of proteinuria, hypertension, and renal insufficiency and it is essential to have prolonged and careful follow-up and to employ strategies that maximize renal preservation.
BMJEarly influences on blood pressure: a study of children aged 5-7 years.
164 Citations1989Peter H. Whincup, Derek G. Cook +1 more
The results imply that delayed motherhood and smaller family size may be associated with higher blood pressure in offspring, and the relation between birth weight and blood pressure may reflect the rate of weight gain in infancy.
American Journal of Kidney DiseasesFocal Sclerosis of Hypertrophied Glomeruli in Solitary Functioning Kidneys of Humans
116 Citations1985Dinyar B. Bhathena, Bruce A. Julian +2 more
Morphometric data on glomerular size are presented on three patients with solitary functioning kidneys and one with bilateral oligomeganephronic hypoplasia and suggest that in the setting of reduced nephron numbers, nephrons destruction via focal glomerulosclerosis may be initiated when compensatory glomerULAR hypertrophy has reached its limits.
Kidney InternationalAge-dependent characteristics of compensatory renal growth
87 Citations1975Joel M. Kaufman, Robert J. Hardy +1 more
The mechanism for enhanced compensatory renal growth in young animals does not involve glomerular neogenesis since there was no evidence for formation of additional nephrons following nephrectomy either in weanling or neonatal animals.
American Journal of Physiology-Renal PhysiologyProgressive glomerular injury after limited renal infarction in the rat
86 Citations1988Timothy W. Meyer, Helmut G. Rennke
These studies support the view that glomerular hypertension is the major hemodynamic derangement contributing to remnantglomerular injury and show that capillary hypertension can initiate remnant glomersular injury even when the majority of the renal mass remains intact.
Pediatric ResearchLong-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat
73 Citations1991Thierry Gilbert, Martine Lelièvre-Pégorier +1 more
It is concluded that in the young rats born with oligonephronia of gentamicin-treated mothers neither the gentamic in remaining in the kidney cells nor the injuries it caused them prevented compensatory adaptation of the kidney to a reduced number of nephrons.
ToxicologyEffects of prenatal and postnatal exposure to gentamicin on renal differentiation in the rat
69 Citations1987Thierry Gilbert, Martine Lelièvre-Pégorier +3 more
It is concluded that administration of gentamicin to pregnant rats caused focal tubular lesions in the developing kidney and a reduced rate of early nephrogenesis, the latter probably due to growth retardation, though a more direct effect of Gentamicin on early neephrogenesis may also have been involved.
The Nephron journals/Nephron journalsClinical Features of Patients with Solitary Kidneys
52 Citations2008Carlo Rugiu, Lamberto Oldrizzi +9 more
Support is added to the view that the reduction of 50% of the renal tissue may be a risky situation in humans as well as in animals.
Pediatric NephrologyImmediate and long-term renal effects of fetal exposure to gentamicin
51 Citations1990Thierry Gilbert, Martine Lelièvre-Pégorier +1 more
Long-term studies of rats born with gentamicin-induced oligonephronia showed that neither the antibiotic still present in kidney several weeks after birth, nor the injuries it caused, prevented renal growth and morphological adaptation of the nephrons to their reduced number.
American Journal of Physiology-Renal PhysiologyGrowth factors and metanephrogenesis
49 Citations1992Marc R. Hammerman, Sharon A. Rogers +1 more
Investigations have defined the localization of growth factor mRNAs, receptors and peptides, delineated patterns of growth factors synthesis, and established the growth factor dependency of embryonic kidney development, which will be summarized in this editorial review.
Archives of Internal MedicineRENAL FUNCTION AND THE NUMBER OF GLOMERULI IN THE HUMAN KIDNEY
47 Citations1939J. M. Hayman
The ideal test of function would give not only an estimate of the degree of loss of renal efficiency but information as to the manner in which the normal physiologic processes have been disturbed.
The Journal of PediatricsBilateral renal hypoplasia with oligonephronia
23 Citations1970Jon I. Scheinman, Herbert T. Abelson
The patient had vomiting, polydipsia, polyuria, hyposthenuria, salt wasting, azotemia, and subsequently renal osteodystrophy and growth retardation and had demonstrably deficient renal ammonia production.
médecine/sciencesCroissance et maturation fœtales
13 Citations1993R Brauner, Francis deZegher
La croissance prenatale est sous la dependance du genome, de l'environnement maternel et de facteurs endocriniens, qui sont probablement influences par le taux circulant maternel de l-insulin like growth factor I (IGF-I).