Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
NeuronPublished 1 October 2005Open access
Elizabeth A. Phelps, Joseph E. LeDoux
Citations3,193
SJR quartileQ1
SJR score6.75
SNIP2.95
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TL;DR
Five major research topics are highlighted that illustrate parallel roles for the amygdala in humans and other animals, including implicit emotional learning and memory, emotional modulation of memory,otional influences on attention and perception, emotion and social behavior, and emotion inhibition and regulation.
Abstract
Research on the neural systems underlying emotion in animal models over the past two decades has implicated the amygdala in fear and other emotional processes. This work stimulated interest in pursuing the brain mechanisms of emotion in humans. Here, we review research on the role of the amygdala in emotional processes in both animal models and humans. The review is not exhaustive, but it highlights five major research topics that illustrate parallel roles for the amygdala in humans and other animals, including implicit emotional learning and memory, emotional modulation of memory, emotional influences on attention and perception, emotion and social behavior, and emotion inhibition and regulation.
Keywords
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Nature reviews. NeuroscienceControl of goal-directed and stimulus-driven attention in the brain
12,975 Citations2002Maurizio Corbetta, Gordon L. Shulman
Evidence for partially segregated networks of brain areas that carry out different attentional functions is reviewed, finding that one system is involved in preparing and applying goal-directed selection for stimuli and responses, and the other is specialized for the detection of behaviourally relevant stimuli.
Annual Review of NeuroscienceEmotion Circuits in the Brain
8,385 Citations2000Joseph E. LeDoux
This work has pin- pointed the amygdala as an important component of the system involved in the acqui- sition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala.
PsychophysiologyEmotion regulation: Affective, cognitive, and social consequences
4,767 Citations2002James J. Gross
This review focuses on two commonly used strategies for down-regulating emotion, reappraisal and suppression, and concludes with a consideration of five important directions for future research on emotion regulation processes.
The Journal of the Acoustical Society of AmericaSome Experiments on the Recognition of Speech, with One and with Two Ears
4,582 Citations1953E. Colin Cherry
ScienceMemory--a Century of Consolidation
4,221 Citations2000James L. McGaugh
This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories.
The Emotional Brain
3,473 Citations1996Joseph E. LeDoux
Molecular PsychiatryThe amygdala: vigilance and emotion
2,867 Citations2000Michael Davis, Paul J. Whalen
A review of available studies examining the human amygdala covers both lesion and electrical stimulation studies as well as the most recent functional neuroimaging studies, and attempts to integrate basic information on normal amygdala function with the current understanding of psychiatric disorders, including pathological anxiety.
NatureFear memories require protein synthesis in the amygdala for reconsolidation after retrieval
2,710 Citations2000Karim Nader, Glenn E. Schafe +1 more
It is shown that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning.
Journal of Cognitive NeuroscienceRethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion
2,533 Citations2002Kevin N. Ochsner, Silvia A. Bunge +2 more
Functional magnetic resonance imaging findings support the hypothesis that prefrontal cortex is involved in constructing reappraisal strategies that can modulate activity in multiple emotion-processing systems.
Annual Review of NeuroscienceTHE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
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Findings from animal and human studies indicate that the amygdala mediates the memory-modulating effects of adrenal stress hormones and several classes of neurotransmitters and plays a key role in enabling emotionally significant experiences to be well remembered.
Journal of NeuroscienceMasked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
2,219 Citations1998Paul J. Whalen, Scott L. Rauch +4 more
This study, using fMRI in conjunction with masked stimulus presentations, represents an initial step toward determining the role of the amygdala in nonconscious processing.
NeuroImageFor better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
2,108 Citations2004Kevin N. Ochsner, Rebecca D. Ray +5 more
Results suggest that both common and distinct neural systems support various forms of reappraisal and that which particular prefrontal systems modulate the amygdala in different ways depends on the regulatory goal and strategy employed.
Annual Review of NeuroscienceNeurobiology of Pavlovian Fear Conditioning
1,839 Citations2001Stephen Maren
Advances in neural circuits underlying fear conditioning have been mapped, synaptic plasticity in these circuits has been identified, and biochemical and genetic manipulations are beginning to unravel the molecular machinery responsible for the storage of fear memories.
NatureNeurons in medial prefrontal cortex signal memory for fear extinction
1,835 Citations2002Mohammed R. Milad, Gregory J. Quirk
It is suggested that consolidation of extinction learning potentiates infralimbic activity, which inhibits fear during subsequent encounters with fear stimuli, indicating that medial prefrontal cortex might store long-term extinction memory.
NeuronExtinction Learning in Humans
1,764 Citations2004Elizabeth A. Phelps, Mauricio R. Delgado +2 more
The neural mechanisms of fear extinction in humans are explored and activation in the vmPFC was primarily linked to the expression of fear learning during a delayed test of extinction, indicating that the mechanisms of extinction learning may be preserved across species.
Physiological ReviewsThe Amygdaloid Complex: Anatomy and Physiology
1,731 Citations2003Pankaj Sah, E. S. Louise Faber +2 more
The anatomical and physiological substrates proposed to underlie amygdala function are examined, suggesting that long-term synaptic plasticity of inputs to the amygdala underlies the acquisition and perhaps storage of the fear memory.
NatureConscious and unconscious emotional learning in the human amygdala
1,686 Citations1998J S Morris, Annelie Bränström Öhman +1 more
The results indicate that the human amygdala can discriminate between stimuli solely on the basis of their acquired behavioural significance, and second, this response is lateralized according to the subjects' level of awareness of the stimuli.
NeuronEffects of Attention and Emotion on Face Processing in the Human Brain
1,654 Citations2001Patrik Vuilleumier, Jorge L. Armony +2 more
Biological PsychiatryContext, ambiguity, and unlearning: sources of relapse after behavioral extinction
1,642 Citations2002Mark E. Bouton
The article concludes with several issues for future research, among them the question of how to optimize extinction and other putative "unlearning" treatments so as to prevent the various forms of relapse discussed here.
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
1,533 Citations1992John P. Aggleton
The Amygdala and Social Behaviour Meidal Temporal Lobe Structures Contributing to Recognition Memory: The Amygdaloid Complex Versus the Rhinal Cortex and the Functional Effects of Amygdala Lesions in Humans Kindling and the Amygdala.
NeuronHuman Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study
1,414 Citations1998Kevin S. LaBar, J. Christopher Gatenby +3 more
FMRI results provide further evidence for the conservation of amygdala function across species and implicate an amygdalar contribution to both acquisition and extinction processes during associative emotional learning tasks.
ScienceDouble Dissociation of Conditioning and Declarative Knowledge Relative to the Amygdala and Hippocampus in Humans
1,396 Citations1995Antoine Bechara, Daniel Tranel +4 more
A patient with selective bilateral damage to the amygdala did not acquire conditioned autonomic responses to visual or auditory stimuli but did acquire the declarative facts about which visual or audio stimuli were paired with the unconditioned stimulus.
Annual Review of PsychologyCENTRAL CHOLINERGIC SYSTEMS AND COGNITION
1,351 Citations1997Barry J. Everitt, Trevor W. Robbins
Evidence is presented that the nucleus basalis-neocortical cholinergic system contributes greatly to visual attentional function, but not to mnemonic processes per se, and it is suggested that nucleus basali-amygdala cholinerential projections have a role in the retention of affective conditioning while brainstem cholinery projections to the thalamus and midbrain dopamine neurons affect basic arousal processes.
NatureLesions of the human amygdala impair enhanced perception of emotionally salient events
1,339 Citations2001Adam K. Anderson, Elizabeth A. Phelps
Under conditions of limited attention for normal perceptual awareness, it is shown that healthy observers demonstrate robust benefits for the perception of verbal stimuli of aversive content compared with stimuli of neutral content.
NatureA mechanism for impaired fear recognition after amygdala damage
1,332 Citations2005Ralph Adolphs, Frédéric Gosselin +4 more
It is shown that SM, a patient with rare bilateral amygdala damage, shows an inability to make normal use of information from the eye region of faces when judging emotions, a defect the authors trace to a lack of spontaneous fixations on the eyes during free viewing of faces.
BrainA neuromodulatory role for the human amygdala in processing emotional facial expressions
1,300 Citations1998J. P. Morris
Functional neuroimaging confirmed that the amygdala and some of its functionally connected structures mediate specific neural responses to fearful expressions and demonstrated that amygdalar responses predict expression-specific neural activity in extrastriate cortex.
Natureβ-Adrenergic activation and memory for emotional events
1,289 Citations1994Larry Cahill, Bruce A. Prins +2 more
The impairment of propranolol on memory of the emotional story was not due either to reduced emotional responsiveness or to nonspecific sedative or attentional effects, which support the hypothesis that enhanced memory associated with emotional experiences involves activation of the β-adrenergic system.
The Brain and Emotion
1,247 Citations1998Edmund T. Rolls
NeuropsychologiaFurther analysis of the hippocampal amnesic syndrome: 14-year follow-up study of H.M.
1,227 Citations1968Brenda Milner, Suzanne Corkin +1 more
Certain residual learning capacities of H.M., a young man who became amnesic in 1953 following a bilateral removal in the hippocampal zone, are delineated against the background of his continuing profound amnesia, an amnesia that persists in spite of above-average intelligence and superior performance on many perceptual tasks.
Nature reviews. NeuroscienceThe amygdala and reward
1,178 Citations2002Mark G. Baxter, Elisabeth A. Murray
Evidence supports a role for the amygdala in processing positive emotions as well as negative ones, including learning about the beneficial biological value of stimuli.
Proceedings of the National Academy of SciencesNeural processing of emotional faces requires attention
1,154 Citations2002Luiz Pessoa, Michael R. McKenna +2 more
Functional magnetic resonance imaging was used to measure activation in regions that responded differentially to faces with emotional expressions compared with neutral faces, and the modulation of these responses by attention was measured, using a competing task with a high attentional load.
Neuroscience & Biobehavioral ReviewsThe amygdala theory of autism
1,133 Citations2000Simon Baron‐Cohen, Howard Ring +4 more
Patients with autism or AS did not activate the amygdala when making mentalistic inferences from the eyes, whilst people without autism did show amygdala activity and the amygdala is proposed to be one of several neural regions that are abnormal in autism.
Journal of NeuroscienceFear and the human amygdala
1,133 Citations1995Ralph Adolphs, Daniel Tranel +2 more
The results show that bilateral, but not unilateral, damage to the human amygdala impairs the processing of fearful facial expressions, and it is proposed that the amygdala is required to link visual representations of facial expressions with representations that constitute the concept of fear.
Nature NeuroscienceDistinct spatial frequency sensitivities for processing faces and emotional expressions
1,104 Citations2003Patrik Vuilleumier, Jorge L. Armony +2 more
An activation of pulvinar and superior colliculus by fearful expressions occurred specifically with low-frequency faces, suggesting that these subcortical pathways may provide coarse fear-related inputs to the amygdala.
ScienceNeural Systems Underlying the Suppression of Unwanted Memories
1,103 Citations2004Michael C. Anderson, Kevin N. Ochsner +6 more
Functional magnetic resonance imaging is used to identify the neural systems involved in keeping unwanted memories out of awareness and establish a neurobiological model for guiding inquiry into motivated forgetting.
Medical Entomology and ZoologySynaptic Self: How Our Brains Become Who We Are
1,086 Citations2002Joseph E. LeDoux
Archives of General PsychiatryCognitive Enhancers as Adjuncts to Psychotherapy
1,063 Citations2004Kerry J. Ressler, Barbara O. Rothbaum +6 more
These pilot data provide initial support for the use of acute dosing of DCS as an adjunct to exposure-based psychotherapy to accelerate the associative learning processes that contribute to correcting psychopathology.
NatureThe human amygdala in social judgment
1,041 Citations1998Ralph Adolphs, Daniel Tranel +1 more
This investigation into the hypothesis that the human amygdala is required for accurate social judgments of other individuals on the basis of their facial appearance finds three subjects with complete bilateral amygdala damage to judge faces of unfamiliar people with respect to two attributes important in real-life social encounters: approachability and trustworthiness.
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1,040 Citations2003Matthew P. Walker, Tiffany Brakefield +2 more
The unique contributions of wake and sleep in the development of different forms of consolidation are described, and it is shown that waking reactivation can turn a previously consolidated memory back into a labile state requiring subsequent reconsolidation.
Journal of Cognitive NeurosciencePerformance on Indirect Measures of Race Evaluation Predicts Amygdala Activation
996 Citations2000Elizabeth A. Phelps, Kevin O’Connor +5 more
The results suggest that amygdala and behavioral responses to Black-versus-White faces in White subjects reflect cultural evaluations of social groups modified by individual experience.
Journal of NeuroscienceThe Role of Ventromedial Prefrontal Cortex in the Recovery of Extinguished Fear
971 Citations2000Gregory J. Quirk, Gregory K. Russo +2 more
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968 Citations1997Asla Pitkänen, Vesa Savander +1 more
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NeuronBrain Systems Mediating Aversive Conditioning: an Event-Related fMRI Study
955 Citations1998Christian Büchel, Jond Morris +2 more
Differential responses of the amygdalae were best characterized by a time by stimulus interaction indicating a rapid adaptation of CS+-specific responses in this region.
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955 Citations2004Patrik Vuilleumier, Mark P. Richardson +3 more
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This review considers the behavioral, cellular, and molecular literatures on extinction and presents the most recent advances in understanding while identifying issues that require considerable further research.
Nature NeuroscienceAmygdala activity related to enhanced memory for pleasant and aversive stimuli
921 Citations1999Stephan Hamann, Timothy D. Ely +2 more
It is shown that bilateral amygdala activity during memory encoding is correlated with enhanced episodic recognition memory for both pleasant and aversive visual stimuli relative to neutral stimuli, and that this relationship is specific to emotional stimuli.
NeuronWhy We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
918 Citations1999Michael S. Fanselow, Joseph E. LeDoux
It is argued that the ABL is involved in the encoding of fear memory and the modulation of memory functions of other structures, including the hippocampus, as well as in a distributed network that encodes the fear memory.
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913 Citations2000Susan J. Sara
The theoretical emphasis on memory reactivation and reconsolidation made here raises the issue, as yet ill addressed by neurobiological experiments, of factors that control or modulate these processes.
Proceedings of the National Academy of SciencesAmygdala activity at encoding correlated with long-term, free recall of emotional information.
910 Citations1996L Cahill, Richard J. Haier +6 more
The findings support the view derived from both animal and human investigations that the AC is selectively involved with the formation of enhanced long-term memory associated with emotionally arousing events.
Neuroscience LettersExtinction of emotional learning: Contribution of medial prefrontal cortex
902 Citations1993Maria A. Morgan, Lizabeth M. Romanski +1 more
It is shown that the medial prefrontal cortex plays an important role in the regulation of fear extinction in rats, a finding that may help elucidate the mechanisms and, possibly, the treatment of disorders of uncontrolled fear, such as anxiety, phobic, panic and posttraumatic stress disorders in humans.
Nature NeuroscienceActivation of the left amygdala to a cognitive representation of fear
900 Citations2001Elizabeth A. Phelps, Kevin O’Connor +4 more
The results suggest that the neural substrates that support conditioned fear across species have a similar but somewhat different role in more abstract representations of fear in humans.
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869 Citations1999Ralph Adolphs, Ralph Adolphs
This work focuses on the amygdala, ventromedial frontal cortices, and right somatosensory-related cortex, which appear to mediate between perceptual representations of socially relevant stimuli and retrieval of knowledge.
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848 Citations2003David Walker, Donna Toufexis +1 more
It is suggested that, although the bed nucleus of the stria terminalis may not be necessary for rapid-onset, short-duration behaviors which occur in response to specific threats, it may mediate slower-onsets, longer-lasting responses that frequently accompany sustained threats, and that may persist even after threat termination.
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837 Citations2004Denis Paré, Gregory J. Quirk +1 more
It is suggested that potentiated LA outputs disinhibit CE projection neurons via GABAergic intercalated neurons, thereby permitting associative plasticity in CE, and accounts for inhibition of conditioned fear after extinction.
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828 Citations2002Benno Roozendaal
The hypothesis is proposed that these apparently dual effects of glucocorticoids on memory consolidation and memory retrieval might be related and that the basolateral complex of the amygdala is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucOCorticoid effects on both memory consolidationand memory retrieval.
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817 Citations2002David Walker, Kerry J. Ressler +2 more
Results indicate that treatments that promote NMDA receptor activity after either systemic or intra-amygdala administration promote the extinction of conditioned fear.
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815 Citations2006Elizabeth A. Phelps, Sam Ling +1 more
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765 Citations2004Paul J. Whalen, Jerome Kagan +9 more
The amygdala was more responsive to fearful (larger" eye whites than to happy (smaller) eye whites presented in a masking paradigm that mitigated subjects' awareness of their presence and aberrant nature.
NeuronCellular and Systems Reconsolidation in the Hippocampus
763 Citations2002Jacek Dębiec, Joseph E. LeDoux +1 more
It is shown that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was reactivated prior to infusion.
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717 Citations2004Florin Dolcos, Kevin S. LaBar +1 more
Results provide direct evidence for the modulation hypothesis in humans and reveal a functional specialization within the MTL regarding the effects of emotion on memory formation.
Annals of the New York Academy of SciencesAssociative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems
709 Citations1999Barry J. Everitt, John A. Parkinson +4 more
Understanding of the special role of the ventral striatum is enriched in coordinating the contribution of different functional subsystems to confer flexibility, as well as coherence and vigor, to goal‐directed behavior, through different forms of associative learning.
Journal of NeuroscienceEvent-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience
700 Citations2000Turhan Canli, Zuo Zhao +3 more
The view that amygdala activation reflects moment-to-moment subjective emotional experience and that this activation enhances memory in relation to the emotional intensity of an experience is supported.
Proceedings of the National Academy of SciencesToward a molecular definition of long-term memory storage
697 Citations1996Craig H. Bailey, Dušan Bartsch +1 more
This work has suggested that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP-inducible cascade of genes and the recruitment of cAMP response element binding protein-related transcription factors.
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674 Citations2004Michael S. Fanselow, Andrew M. Poulos
This chapter describes the orientation that the neuroscience of learning has taken and review some of the progress made within that orientation, by describing studies using mutant mice, brain stimulation and recording, brain lesions and direct pharmacological manipulations of specific brain regions.
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660 Citations2000Helen Barbas
The integration of cognitive, mnemonic and emotional processes is likely to be disrupted in psychiatric and neurodegenerative diseases which preferentially affect limbic cortices and consequently disconnect major feedback pathways to the neuraxis.
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658 Citations2003Larry Cahill, Łukasz Górski +1 more
Cold pressor stress, which significantly elevated salivary cortisol levels, enhanced memory for emotionally arousing slides compared with the controls, but did not affect memory for relatively neutral slides, which further support the view that post-learning stress hormone-related activity interacts with arousal at initial encoding to modulate memory consolidation.
NatureDifferent types of fear-conditioned behaviour mediated by separate nuclei within amygdala
656 Citations1997Simon Killcross, Trevor W. Robbins +1 more
This work shows that distinct neural systems involving separate amygdaloid nuclei mediate different types of conditioned fear behaviour, and suggests that theories of amygdala function should take into account the roles of discrete amygdala subsystems in controlling different components of integrated emotional responses.
Journal of NeuroscienceImpaired fear conditioning following unilateral temporal lobectomy in humans
639 Citations1995KS LaBar, JE LeDoux +2 more
Results show that temporal lobe structures in humans, as in other mammals, are important components in an emotional memory network.
Learning & MemorySynaptic Plasticity in the Lateral Amygdala: A Cellular Hypothesis of Fear Conditioning
620 Citations2001Hugh T. Blair, Glenn E. Schafe +3 more
It is proposed that the CS evokes EPSPs at sensory input synapses onto LA pyramidal neurons, and that the US strongly depolarizes these same LA neurons, which induce LTP-like changes that store memories during fear conditioning.
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602 Citations2004Jacek Dębiec, Joseph E. LeDoux
If the effects on reconsolidation are verified in humans, the results would suggest the possibility that propranolol after memory retrieval might be an effective way of treatment of intrusive memories in PTSD.
Trends in Cognitive SciencesAmygdala circuitry in attentional and representational processes
602 Citations1999Peter C. Holland, Michela Gallagher
Recent evidence that links the amygdala to several aspects of food-motivated associative learning, including functions often characterized as attention, reinforcement and representation is discussed.
Journal of NeuroscienceMemory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala
598 Citations2000Glenn E. Schafe, Joseph E. LeDoux
It is suggested that the LA is essential for memory consolidation of auditory fear conditioning and that this process is PKA and protein-synthesis dependent.
Nature NeuroscienceNeuronal activity in human primary visual cortex correlates with perception during binocular rivalry
597 Citations2000Alex Polonsky, Randolph Blake +2 more
FMRI signals in early visual cortex were measured while subjects viewed rival dichoptic images of two different contrasts; the contrast difference served as a 'tag' for the neuronal representations of the two monocular images.
BrainDifferential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field
591 Citations2001J. S. Morris
Trends in NeurosciencesMemory consolidation and the amygdala: a systems perspective
570 Citations2002James L. McGaugh
Investigation of the involvement of BLA projections to other brain regions is essential for understanding influences of the amygdala on different aspects and forms of memory.
Journal of NeuroscienceNeural Correlates of the Automatic Processing of Threat Facial Signals
568 Citations2003Adam K. Anderson, Kalina Christoff +3 more
The results suggest that automaticity is not fundamental to the processing of all facial signals of threat, but is unique to amygdala processing of fear, which is specific to fear only during attended processing, and more broadly tuned to threat during unattended processing, when cortical processing is diminished.
Choice Reviews OnlineMemory distortion: how minds, brains, and societies reconstruct the past
558 Citations1996
NeuroscienceTopographic organization of projections from the amygdala to the visual cortex in the macaque monkey
557 Citations2003David G. Amaral, Hamraz Behniea +1 more
The topography of amygdaloid projections to the visual cortices in the macaque monkey was examined and it was confirmed that the amygdala gives rise to feedback projections to all levels of the "ventral stream" visual pathway.
NeuronFear Conditioning Enhances Different Temporal Components of Tone-Evoked Spike Trains in Auditory Cortex and Lateral Amygdala
555 Citations1997Gregory J. Quirk, Jorge L. Armony +1 more
Rapid conditioning of fear responses to potentially dangerous stimuli depends on plasticity in the amygdala, while cortical areas may be particularly involved in higher cognitive (mnemonic and attentional) processing of fear experiences.
Journal of NeuroscienceSubcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli
523 Citations1984JE LeDoux, Akira Sakaguchi +1 more
It is demonstrated that lesions of MG and lower auditory centers, but not lesions of the auditory cortex, block autonomic and behavioral conditioned emotional responses coupled to acoustic stimuli and indicate that subcortical rather than cortical efferents of MG sustain these responses.
Proceedings of the National Academy of SciencesFear fosters flight: A mechanism for fear contagion when perceiving emotion expressed by a whole body
520 Citations2004Béatrice de Gelder, Josh Snyder +3 more
Functional MRI is used to clarify how the brain recognizes happiness or fear expressed by a whole body and indicates that observing fearful body expressions produces increased activity in brain areas narrowly associated with emotional processes.
Learning and Computational Neuroscience: Foundations of Adaptive Networks
519 Citations1990Michael Gabriel, John Moore
"Learning and Computational Neuroscience" presents recent advances in understanding the brain processes underlying learning and memory, including neural systems analyses of dynamic circuit interactions in the brain and computational models capable of describing simple forms of learning and performance.
ScienceStability of Retrieved Memory: Inverse Correlation with Trace Dominance
515 Citations2003Mark Eisenberg, Tali Kobilo +2 more
It is reported that in both conditioned taste aversion in the rat and fear conditioning in the medaka fish, the stability of retrieved memory is inversely correlated with the control of behavior by that memory.
Trends in NeurosciencesMemory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective
513 Citations2001Glenn E. Schafe, Karim Nader +2 more
It is suggested that fear memory consolidation in the amygdala shares essential biochemical features with LTP, and hold promise for understanding the relationship between memory consolidation and synaptic plasticity in the mammalian brain.
NeuronMolecular Mechanisms Underlying Emotional Learning and Memory in the Lateral Amygdala
489 Citations2004Sarina M. Rodrigues, Glenn E. Schafe +1 more
Given that the neural circuit underlying fear conditioning has been implicated in emotional disorders in humans, the molecular mechanisms of fear conditioning are potential targets for psychotherapeutic drug development.
ScienceAmygdala Response to Happy Faces as a Function of Extraversion
486 Citations2002Turhan Canli, Heidi Sivers +3 more
Cognitive neuroscience aims to delineate principles of brain-behavior relations by characterizing both common mechanisms across, and individual differences among, individuals, and both approaches are relevant for the study of the amygdala.
NeuronTemporally Graded Requirement for Protein Synthesis following Memory Reactivation
465 Citations2002Maria H. Milekic, Cristina M. Alberini
It is shown that the requirement for protein synthesis of a reactivated memory is evident only when the memory is recent, and that memory vulnerability decreases as the time between the original training and the recall increases.
Journal of NeuroscienceEquipotentiality of thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning
459 Citations1992LM Romanski, JE LeDoux
Destruction of either pathway alone had no effect on auditory fear conditioning, however, combined lesions of the two sensory pathways disrupted conditioning.
Neurobiology of Learning and MemoryEpinephrine enhancement of human memory consolidation: Interaction with arousal at encoding
455 Citations2003Larry Cahill, Michael T. Alkire
These findings support the view that endogenous stress hormones modulate memory consolidation for experiences that induce their release and suggest that in humans these hormones may interact with the degree of arousal at initial encoding of information to modulates memory consolidation processes for that information.
Nature NeuroscienceTwo different lateral amygdala cell populations contribute to the initiation and storage of memory
437 Citations2001J. Christopher Repa, Jeff Muller +4 more
Neuronal responses elicited by the conditioned stimulus typically increased before behavioral fear was evident, supporting the hypothesis that neural changes in LAd account for the conditioning of behavior.
Psychological ScienceArousal-Mediated Memory Consolidation: Role of the Medial Temporal Lobe in Humans
435 Citations1998Kevin S. LaBar, Elizabeth A. Phelps
A group difference in the effect of arousal on the rate of forgetting suggests that the role of medial temporal lobe structures in memory consolidation for arousing events is conserved across species.
HippocampusNew life in an old idea: The synaptic plasticity and memory hypothesis revisited
432 Citations2002Stephen J. Martin, Richard Morris
There is now compelling evidence that changes in synaptic strength occur as a consequence of certain forms of learning, a major challenge will be to determine whether such changes constitute the memory trace itself or play a less specific supporting role in the information processing that accompanies memory formation.
NeuronBrain Responses to the Acquired Moral Status of Faces
418 Citations2004Tania Singer, Stefan J. Kiebel +3 more
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416 Citations2004Francisco Sotres-Bayón, David E. Bush +1 more
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Journal of NeuroscienceThe Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate
415 Citations2004Ned H. Kalin, Steven E. Shelton +1 more
Results suggest that similar to rodent species, the primate CeA plays a role in mediating fear- and anxiety-related behavioral and endocrine responses and patterns of asymmetric frontal brain electrical activity, as assessed by regional scalp EEG, did not significantly differ between control and lesioned monkeys.
Memory: From Mind to Molecules
414 Citations1999Larry R. Squire, Eric R. Kandel
Current Opinion in NeurobiologyThe amygdala and emotion
406 Citations1996Michela Gallagher, Andrea A. Chiba
The use of animal models has progressively defined the circuitry for these functions within the amygdala and its interconnections with other brain systems, including pathways through which the amygdala modulates memory and regulates attention.
…