INFECTIOUS AGAMMAGLOBULINEMIA: TRANSMISSION OF IMMUNODEFICIENCY WITH GRAFTS OF AGAMMAGLOBULINEMIC CELLS
The Journal of Experimental MedicinePublished 1 October 1974Open access
R. Michael Blaese, Paul L. Weiden, Irma R. Koski, Nancy J. Dooley
Citations114
SJR quartileQ1
SJR score5.83
SNIP1.99
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation.
Abstract
Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation. The immunodeficiency which develops in the recipients persists for life and is characterized by inability to produce antibody and by progressive loss of detectable serum IgM and IgG.
Keywords
Immunology and MicrobiologyMedicine
PubMedInfectious immunological tolerance.
804 Citations1971Richard K. Gershon, Kazunari Kondo
The immunosuppressive effect of the presence of thymocytes during the antigen Pretreatment was studied by adoptively transferring the spleen cells of the antigen pretreated mice to thymus-deprived chimeras.
The Journal of ImmunologyChromic Chloride: A Coupling Reagent for Passive Hemagglutination Reactions
520 Citations1967E. R. Gold, H. Hugh Fudenberg
The present studies showed that group O human red cells coated with antigen by the CrCl3 procedure can be used in a number of serologic reactions, and use of CrCl 3-treated cells as immunoadsorbent provides a rapid method for the preparation of monospecific antisera to human immunoglobulins.
European Journal of ImmunologyBursal and postbursal stem cells in chicken. functional characteristics
195 Citations1973Paavo Toivanen, Auli Toivanen
The results indicate that stem cells or progenitor cells for the B cell line in chicken can be divided into a bursal stem cell and a postbursalstem cell, both of these cell types are effective in restoring antibody formation of CY‐treated chickens.
PubMedEnhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum.
127 Citations1970Phillip J. Baker, Rolf F. Barth +2 more
The Journal of Experimental MedicineACTIVE SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS
117 Citations1973Leonore A. Herzenberg, Eva L. Chan +3 more
Thymus-derived cells (T cells) that actively suppress production of IgG2a immunoglobulins carrying the Ig-1b allotype have been found in adult (SJL x BALB/c)F1 mice exposed to anti-Ig-1B early in life.
The Journal of Experimental MedicineACTIVE SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS
103 Citations1972E. B. Jacobson, Leonore A. Herzenberg
The results suggest that long-term allotype suppression resulting from perinatal exposure of offspring to specific anti-allotype antibody (anti-Ig-1b), is not due merely to an absence of Ig-1B-producing cells or their progenitors, but appears to be an active process, which dominates physiologically over normal production.
PubMedOntogeny of bursal function in chicken. II. Postembryonic stem cell for humoral immunity.
96 Citations1972Paavo Toivanen, Auli Toivanen +2 more
The Journal of Experimental MedicineACTIVE SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS
94 Citations1972E. B. Jacobson, Leonore A. Herzenberg +2 more
Evidence is interpreted as evidence that chronic allotype suppression in mice is actively maintained by cells which are resident in the lymphoid tissues, splenic cells being the most effective.
The Journal of Experimental MedicineIMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS
85 Citations1964R. Michael Blaese, Carlos Alberto Martínez +1 more
The failure of the injected parent strain cells to respond to the antigen used may imply immunologic commitment of these cells, and the basis for the immunologic incompetence of the host with respect to T2 phage is presumed to be the attack of immunologically competent donor cells on the lymphoid cells of the recipient.
The Journal of Experimental MedicineSTUDIES ON THYMUS FUNCTION
79 Citations1970Osias Stutman, Edmond J. Yunis +1 more
A population of paritally differentiated cells of hemopoietic origin, termed postthymic, sensitive to humoral activity of the thymus and present in the lymphohemopoetic tissues of adult and newborn mice is postulated to explain the results.
The Journal of Experimental MedicinePOKEWEED MITOGEN-, CONCANAVALIN A-, AND PHYTOHEMAGGLUTININ-INDUCED DEVELOPMENT OF CYTOTOXIC EFFECTOR LYMPHOCYTES
40 Citations1973Holger Kirchner, R. Michael Blaese
Results indicate that the development of cytotoxic effector lymphocytes in mitogen-treated leucocyte cultures is a property of T lymphocytes, and although bone marrow cells fail to proliferate in response to these phytomitogens, they do have strong cytot toxic reactivity suggesting that different subsets of thymic-derived lymphocytes are responsible for mitogens-induced transformation and mitogen -induced cytotoxicity.
European Journal of Immunology<i>in vitro</i> studies of allotype suppression in mice
33 Citations1973E. B. Jacobson
Long‐term allotype suppression in (SJL x BALB/c)F1 mice has been investigated in vitro, using a culture system which can be maintained over a period of at least 2 weeks.
Scandinavian Journal of ImmunologyMigration of Bone Marrow Cells to the Bursa of Fabricius and the Spleen in the Chicken
20 Citations1973Ove Bäck, R. Bäck +3 more
Bone marrow of chickens of different ages was labelled locally in vivo with small amounts of 3H‐thymidine directly into the bone marrow to demonstrate traffic of progenitor cells for the bursal cell line and no bone marrow‐derived cells could be localized in the germinal centers of the spleens or the cecal tonsils.