Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women
Clinical EndocrinologyPublished 1 February 1998
S. Adami, N. Zamberlan, Roberto Castello, Flavia Tosi, Davide Gatti, Paolo Moghetti
Citations78
SJR quartileQ2
SJR score1.01
SNIP1.11
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Abstract
The results of this study suggest that in patients with polycystic ovary syndrome the deleterious effect on bone of amenorrhoea is balanced by androgen overproduction.
Keywords
Medicine
New England Journal of MedicinePolycystic Ovary Syndrome
2,459 Citations1995Stephen Franks
It is now clear that the range of presenting symptoms of women with polycystic ovaries includes not only nonhirsute women with oligomenorrhoea or amenorrhOEa but also hirsute subjects with regular, ovulatory cycles.
Endocrine ReviewsPolycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*
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Patients with the severest cases may have hyperthecosis, a form in which there are no cysts, and those with milder ovarian dysfunction tend to have normal ovarian morphology.
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404 Citations1989Christian Kasperk, Jon E. Wergedal +4 more
It is concluded that androgens can stimulate human and murine osteoblastic cell proliferation in vitro, and induce expression of the osteoblast-line differentiation marker ALP, presumably by an androgen receptor mediated mechanism.
American Journal of Obstetrics and GynecologyEpidemiology of secondary amenorrhea
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Findings indicate that the true incidence of secondary amenorrhea due to previous use of oral contraceptive agents is very low, .7% in the present study.
The Journal of Clinical Endocrinology & MetabolismThe insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women.
233 Citations1996Paolo Moghetti, Flavia Tosi +7 more
Antiandrogen treatment partially reversed the peripheral insulin resistance associated with hyperandrogenism regardless of which antiandrogen was used, suggesting that in women, androgen excess per se contributes to impairment of insulin action.
The Journal of Clinical Endocrinology & MetabolismVertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women.
213 Citations1993F. Trémollières, J. M. Pouillès +1 more
Within the first years after menopause, moderate excess body weight significantly reduces vertebral postmenopausal bone loss, probably related to excess adipose tissue through increased conversion of estrogen from adrenal precursors and/or increased production of adrenal androgens.
American Journal of Obstetrics and GynecologyPrevalence of oligomenorrhea and amenorrhea in a college population
189 Citations1982Gloria Bachmann, Ekkehard Kemmann
In most women with oligomenorrhea or amenorrhea, menstrual irregularity was present prior to college entry and with the use of self-administered questionnaires, any specific college stress could not be identified to account for the presence of menstrual abnormalities in a college population.
Fertility and SterilityPolycystic ovaries as a relative protective factor for bone mineral loss in young women with amenorrhea
67 Citations1992Costantino Di Carlo, Zeev Shoham +4 more
Clinical EndocrinologyBONE MASS IN HIRSUTE WOMEN WITH ANDROGEN EXCESS
65 Citations1989Jill E. Dixon, A Rodin +3 more
It is concluded that androgen excess can maintain normal bone mass in the face of low or undetectable oestradiol levels.
BoneThe effects of androgens on the mechanical properties of primate bone
50 Citations1995Mehran Kasra, Marc D. Grynpas
In the young cynomolgus monkey, long-term androgenic treatment significantly improves some of the mechanical properties of both cortical and trabecular bones, increases bone density, and the stronger the androgen, likely, the more pronounced is the effect.
