What is the prior probability of a proposed new treatment being superior to established treatments?
BMJPublished 4 January 1997
Iain Chalmers
Citations44
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Keywords
MedicineEconomics, Econometrics and Finance
Annals of Internal MedicineCosts, Risks, and Benefits of Surgery.
490 Citations1978
From the combination of knowledge and actions, someone can improve their skill and ability and this will lead them to live and work much better.
BMJTelling parents all relevant details might reduce recruitment of children to trials
13 Citations1996Terence Stephenson, Damilola Walker
Patients in clinical trials have “the right to know all relevant details about the situation in which they find themselves” but often such equipoise does not exist because the investigators suspect that one treatment is superior but a randomised controlled trial is still necessary.
BMJReply from dissenting author
10 Citations1996Rob Moodie
A former chairman of the voluntary organisation Tak Tent, and an author of the paper, I wish to respond to the comments with a different perspective from that of my coauthors about the lack of informed consent.
BMJGaining patients' consent: Description of orthopaedic operations is inaccurate in half of consent forms
4 Citations1996Ian Callanan, J M Pegum