Serotonin and Hippocampal Neurogenesis
NeuropsychopharmacologyPublished 1 August 1999Open access
Elizabeth Gould
Citations328
SJR quartileQ1
SJR score2.94
SNIP1.99
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TL;DR
The dentate gyrus continues to produce new granule neurons well into adulthood, and results present the possibility that the inhibitory effects of stress on granule cell production may be prevented by 5HT1A receptor agonists.
Abstract
The dentate gyrus continues to produce new granule neurons well into adulthood. This has been demonstrated for many mammalian species, from rodents to primates. The proliferation of granule cell precursors can be suppressed by stressful experiences, presumably via adrenal steroids. Recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5HT1A receptor. These results present the possibility that the inhibitory effects of stress on granule cell production may be prevented by 5HT1A receptor agonists.
Keywords
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