Combination Therapy with Ibuprofen and Methadone for Chronic Cancer Pain
The American Journal of MedicinePublished 1 July 1984
Theresa Ferrer-Brechner, Peter Ganz
Citations91
SJR quartileQ1
SJR score1.00
SNIP1.04
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TL;DR
Results show that the addition of 600 mg of ibuprofen to either 2.5 or 5 mg of methadone significantly increased analgesia, without concomitantly increasing side effects or euphoria.
Abstract
This randomized double-blind crossover study compares the narcotic methadone alone with methadone in combination with the peripherally acting, antiprostaglandin agent ibuprofen (Motrin, Upjohn) in 28 patients with moderate to severe cancer-related pain, who were already using a narcotic for pain relief. Results show that the addition of 600 mg of ibuprofen to either 2.5 or 5 mg of methadone significantly increased analgesia, without concomitantly increasing side effects or euphoria.
Keywords
Medicine
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