Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?

Toxicology LettersPublished 1 November 1996

Ken Donaldson

DOI10.1016/0378-4274(96)03752-6

Source URL

Citations284

SJR quartileQ2

SJR score0.77

SNIP0.78

TL;DR

Abstract

Using a sensitive phi X174 RF plasmid DNA assay, free radical activity was detected at the surface of normal and ultrafine titanium dioxide (TiO2), environmental particles (PM-10), asbestos and a range of man-made fibres. There were differences in the amount of free radical activity that was detected, with ultrafine TiO2 being much more active than normal-sized TiO2; PM-10 also had substantial free radical activity. Amphibole asbestos samples were highly active, whilst man-made fibres were much less active than asbestos. For all of the particles, the DNA damage could be ameliorated by mannitol, showing that hydroxyl radicals were involved. The ability of particles to generate free radicals at or near their surface, and thereby impose oxidant stress in key target cells, could be central to determining their pathogenicity.

Keywords

MedicineEnvironmental Science

The LancetParticulate air pollution and acute health effects

2,172 Citations1995Anthony Seaton, David Godden +2 more

It is suggested that ultra-fine particles in the nature of the urban particulate cloud are able to provoke alveolar inflammation, with release of mediators capable, in susceptible individuals, of causing exacerbations of lung disease and of increasing blood coagulability, thus also explaining the observed increases in cardiovascular deaths associated with urban pollution episodes.

Free Radical Research CommunicationsNuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1,407 Citations1992Ralf Schreck, Kaj Albermann +1 more

The evidences that NF-kB is an oxidative stress-responsive transcription factor that is triggered by a great variety of agents, including viruses, double-stranded RNA, endotoxins, phorbol esters, UV light and ionizing radiation are discussed.

American Journal of Respiratory Cell and Molecular BiologyPulmonary Retention of Ultrafine and Fine Particles in Rats

729 Citations1992J Ferin, Günter Oberdörster +1 more

Both acute instillation and subchronic inhalation studies showed that ultrafine particles at equivalent masses access the pulmonary interstitium to a larger extent than fine particles (integral of 250 nm).

The FASEB JournalFunctions of glutathione and glutathione disulfide in immunology and immunopathology

442 Citations1994Wulf Dröge, Klaus Schulze‐Osthoff +6 more

It is proposed that the well‐known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency, and hypothesize that AIDS may be the consequence of a G SSG deficiency as well.

Free Radical Biology and MedicineThe role of free radicals in asbestos-induced diseases

427 Citations1992David W. Kamp, Philip Graceffa +2 more

There is strong evidence supporting the premise that reactive oxygen species and/or free radicals contribute to asbestos-induced and cigarette smoke/asbestos-induced lung injury and that strategies aimed at reducing the oxidant stress on pulmonary cells may attenuate the deleterious effects of asbestos.

Chemico-Biological InteractionsRegulation of the transcription factors NF-κB and AP-1 by redox changes

310 Citations1994Markus Meyer, Heike L. Pahl +1 more

The antioxidant-mediated activation of AP-1 relies on the de novo synthesis of c-fos and c-jun mRNAs, and SRE binding factors can be considered as primary antioxidant response factors, whileAP-1 itself is a secondary response factor.

PubMedInduction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.

127 Citations1995Yvonne M. W. Janssen, Nicholas H. Heintz +1 more

CarcinogenesisDetection of surface free radical activity of respirable industrial fibres using supercoiled φX174 RF1 plasmid DNA

63 Citations1995Peter S. Gilmour, P.H. Beswick +2 more

The loss of ability to damage DNA in DSF-B-treated asbestos fibres shows that iron at the surface of asbestos fibre definitely has a role in generating hydroxyl radicals, however, it is clear that some fibres, such as short amosite and MMVF 21, release large quantities of iron without causing free radical damage, whilst neither long amosite nor crocidolite released more iron than the other fibres.

Annual reports in medicinal chemistryChapter 24. Transcription Factor NF-κB: An Emerging Regulator of Inflammation

38 Citations1994Anthony M. Manning, Donald C. Anderson

This work has shown that the recruitment of blood leukocytes to the sites of inflammation involves a well coordinated and dynamic sequence of events in that several endothelial cell adhesion molecules (CAMs) and chemotactic cytokines play an active role and references therein.

The Annals of Occupational HygieneHydrogen Peroxide Increases the Iron-Catalysed Induction of DNA Single-Strand Breaks by Asbestos

4 Citations1994A.E. Aust, Chien‐Chung Chao +1 more