Insulin Resistance — Mechanisms, Syndromes, and Implications
New England Journal of MedicinePublished 26 September 1991
David E. Moller, Jeffrey S. Flier, Jeffrey S. Flier
Citations799
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
This review discusses current concepts of the mechanisms of insulin action and insulin resistance and the implications of insulin resistance for a variety of disorders, including obesity, diabetes mellitus, ovarian hyperan-drogenism, and possibly hypertension.
Abstract
The past 20 years have witnessed a remarkable increase in our knowledge of the cellular and molecular mechanisms that underlie the diverse actions of insulin, the central hormone of metabolic regulation. Interest in the molecular details of insulin action has been heightened by the prevalence of insulin resistance and by the fact that insulin resistance has a key role in the pathogenesis of many disorders, including obesity, diabetes mellitus, ovarian hyperan-drogenism, and possibly hypertension. In this review, we discuss current concepts of the mechanisms of insulin action and insulin resistance and the implications of insulin resistance for a variety of . . .
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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72 Citations1990F Shimada, Masato Taira +10 more
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69 Citations1981Helena Wachslicht-Rodbard, Michele Muggeo +4 more
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67 Citations1991David E. Moller, Heike Benecke +1 more
It is concluded that transfected kinase-deficient insulin receptor mutants derived from insulin-resistant patients have distinct defects in the ability to mediate insulin action in vitro, and normal activation of the receptor tyrosine kinase by insulin is not necessarily required for signaling of certain important biologic actions.
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64 Citations1984L Budohoski, R. A. John Challis +2 more
The concentration of insulin that produces half‐maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2‐chloroadenosine and N 6‐phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8‐phenYLtheophylline.
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56 Citations1989Steven R. Hager
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50 Citations1991Jyotirmoy Kusari, Yasumitsu Takata +4 more
A 22-year-old diabetic woman with Type A insulin resistance and acanthosis nigricans is identified and a missense mutation in the kinase domain mutation at position 981 is biologically significant leading to insulin resistance.
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43 Citations1990Alessandro Cama, Amy P. Patterson +7 more
Observations are consistent with the interpretation that the defects in insulin receptor function are acquired rather than derived from defects in the primary structure of the receptor.
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43 Citations1988M J King, Graham J. Sale
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