Randomized Controlled Trial of 3 vs 10 Days of Trimethoprim/Sulfamethoxazole for Acute Maxillary Sinusitis
JAMAPublished 5 April 1995
John W Williams
Citations107
SJR quartileQ1
SJR score5.35
SNIP10.71
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Clinical symptoms and radiograph scores improved equally following 3 or 10 days of TMP/SMX plus oxymetazoline nasal spray, and Symptomatic relapse and recurrence were similar between groups.
Abstract
At the 2-week follow-up, clinical symptoms and radiograph scores improved equally following 3 or 10 days of TMP/SMX plus oxymetazoline nasal spray. Symptomatic relapse and recurrence were similar between groups. Three days of antibiotics were as effective as 10 days and, because of the high disease prevalence, hold the potential for substantial cost savings.
Keywords
Medicine
Wiley series in probability and statisticsStatistical Methods for Rates and Proportions
18,048 Citations2003Joseph L. Fleiss, Bruce Levin +1 more
The American StatisticianA Leisurely Look at the Bootstrap, the Jackknife, and Cross-Validation
2,963 Citations1983Bradley Efron, Gail Gong
Journal of the American Statistical AssociationBootstrapping: A Nonparametric Approach to Statistical Inference.
1,375 Citations1994Aa, Christopher Z. Mooney +1 more
New England Journal of MedicineComputed Tomographic Study of the Common Cold
669 Citations1994Jack M. Gwaltney, C. Douglas Phillips +2 more
The common cold is associated with frequent and variable anatomical involvement of the upper airways, including occlusion and abnormalities in the sinus cavities.
JAMAEmergence of Drug-Resistant Pneumococcal Infections in the United States
551 Citations1994Robert F. Breiman
Current recommendations for use of 23-valent pneumococcal capsular polysaccharide vaccines should be aggressively promoted and that development and evaluation of new conjugate pneumococCal vaccines may be a crucial part of strategies for prevention are suggested.
BiometricsSignificance Testing to Establish Equivalence between Treatments, with Special Reference to Data in the Form of 2 x 2 Tables
395 Citations1977Charles W. Dunnett, Michael Gent
It is found that the test based upon chi2 with continuity correction agrees best overall with Gart's (1971) test and is therefore recommended for use when computational facilities needed for carrying out the latter are not available.
New England Journal of MedicineSinusitis of the Maxillary Antrum
380 Citations1975Frank O. Evans, J. Brantley Sydnor +11 more
In acute sinusitis, there was a strong correlation between high aspirate leukocyte counts and infection as manifested by bacterial titers of greater than 10(5) per milliliter or the isolation of virus fungus (P greater than 0.001).
Archives of Otolaryngology - Head and Neck SurgeryPrevalence of Incidental Abnormalities on Computed Tomographic Scans of the Paranasal Sinuses
316 Citations1988Thomas Havas, J. Motbey +1 more
The high frequency of reported radiologic abnormalities in asymptomatic patients highlights the importance of correlation with the clinical presentation when interpreting computed tomographic scans of the paranasal sinuses.
JAMAA Proposal for Structured Reporting of Randomized Controlled Trials
310 Citations1994Erik Andrew
A RANDOMIZED controlled trial (RCT) is the most reliable method of assessing the efficacy of health care interventions and reports of RCTs should provide readers with adequate information about what went on in the design, execution, analysis, and interpretation of the trial.
Statistics in MedicineBootstrap investigation of the stability of a cox regression model
309 Citations1989Douglas G. Altman, Per Kragh Andersen
A bootstrap investigation of the stability of a Cox proportional hazards regression model resulting from the analysis of a clinical trial of azathioprine versus placebo in patients with primary biliary cirrhosis shows graphically that these intervals are markedly wider than those obtained from the original model.
PEDIATRICSComparative Effectiveness of Amoxicillin and Amoxicillin-Clavulanate Potassium in Acute Paranasal Sinus Infections in Children: A Double-Blind, Placebo-Controlled Trial
287 Citations1986Ellen R. Wald, Darleen Chiponis +1 more
Children treated with an antibiotic were more likely to be cured than children receiving placebo and the overall cure rate was 67% forAmoxicillin, 64% for amoxicillin-clavulanate potassium, and 43% for placebo.
Annals of Internal MedicineClinical Evaluation for Sinusitis
236 Citations1992John W Williams, David L. Simel +2 more
General internists, focusing on five clinical findings and their overall clinical impression, can effectively stratify male patients with sinus symptoms as having a high, intermediate, or low probability of sinusitis.
The Journal of Infectious DiseasesEtiology and Antimicrobial Therapy of Acute Maxillary Sinusitis
228 Citations1979Bruce H. Hamory, Merle A. Sande +3 more
Clinical and bacteriologic responses to all three regimens were good, and the efficacy of therapy with orally administered ampicillin, amoxicillin, or trimethoprim-sulfamethoxazole was evaluated by a repeat sinus puncture and culture.
Archives of Internal MedicineWhen Was a 'Negative' Clinical Trial Big Enough?
215 Citations1985Allan S. Detsky
This work suggests that this "prospective" sample size calculation is incorrect, for once the trial is over the authors have "hard" data from which to estimate the actual size of the treatment effect.
Annals of Otology Rhinology & LaryngologyEtiology and Antimicrobial Treatment of Acute Sinusitis
170 Citations1981Jack M. Gwaltney, Austin Sydnor +1 more
Ampicillin, amoxicillin, trimethoprim-sulfamethoxazole, and cefaclor have been shown to be effective treatment for most cases of acute sinusitis.
Journal of Allergy and Clinical ImmunologyIntranal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis
148 Citations1993Eli O. Meltzer, H.Alice Orgel +9 more
The addition of flunisolide topical nasal spray as an adjunct to antibiotic therapy was most effective in global evaluations, tended to improve symptoms, to decrease inflammatory cells in nasal cytograms, to normalize ultrasound scans, and to aid regression of radiographic abnormalities compared with placebo spray.
Acta Oto-LaryngologicaAnalysis of Symptoms and Clinical Signs in the Maxillary Sinus Empyema
145 Citations1988Olof Berg, C. Carenfelt
Local symptoms such as pain and purulent rhinorrhea with unilateral predominance were particularly guiding, even in bilateral cases, while nasal obstruction, tenderness during percussion, and affected general condition were not.
European Journal of Clinical Microbiology & Infectious DiseasesThe second European collaborative study on the frequency of antimicrobial resistance inHaemophilus influenzae
119 Citations1990F. H. Kayser, G. Morenzoni +1 more
In the second European survey of the prevalence of antimicrobial resistance inHaemophilus influenzae, 2529 clinical isolates collected in 1988/89 from 78 laboratories in nine countries were examined and the incidence of beta-lactamase producing strains was similar to that seen in the first European study performed in 1986.
BMJUse of symptoms and signs to diagnose maxillary sinusitis in general practice: comparison with ultrasonography.
99 Citations1992N. P. van Duijn, H. J. Brouwer +1 more
The five symptoms algorithm would improve diagnostic accuracy of general practitioners, but incorrect and uncertain diagnoses cannot be avoided.
Acta Oto-LaryngologicaThe Correlation Between the Radiological Examination and the Irrigation Findings in Maxillary Sinusitis
93 Citations1970A. Axelsson, N. Grebelius +2 more
The present investigation correlates further the fluid demonstrated by radiological examination with secretion demonstrated by irrigation, and recommends a 5th projection for routine purposes in cases where the four standard projections are used.
Acta Oto-LaryngologicaTreatment of Acute Maxillary Sinusitis
81 Citations1970A. Axelsson, N. Chidekel +2 more
The patient's evaluation of the treatment after 5 days did not correlate with the radiological state but did so after 10 days, and a group treated with nasal decongestant only, may be regarded as a control group.
Archives of Otolaryngology - Head and Neck SurgeryMaxillary Sinus Abnormalities: Radiographic Evidence in an Asymptomatic Population
69 Citations1969F. W. Fascenelli
The abnormalities reported in this paper were identified during comprehensive medical screening of healthy patients and to what degree these findings constitute disease remains to be defined.
The American Journal of MedicineAzithromycin and amoxicillin in the treatment of acute maxillary sinusitis
65 Citations1991Roy R. Casiano
A 5- day course of azithromycin proved to have efficacy, safety, and tolerability that was equal to a 10-day course (three doses per day) of amoxicillin in the treatment of acute bacterial sinusitis.
The American Journal of MedicineClinical comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of patients with acute bacterial maxillary sinusitis
64 Citations1992Alfonso E. Camacho, Roxana Cobo +8 more
Cefuroxime axetil twice a day is as effective as amoxicillin/clavulanate three times a day in the treatment of acute bacterial maxillary sinusitis but produces fewer adverse effects.
Journal of Antimicrobial ChemotherapyThe comparative efficacy and safety of clarithromycin and amoxycillin in the treatment of outpatients with acute maxillary sinusitis
64 Citations1991P. Karma, J. Pukander +6 more
It is suggested that clarithromycin is as effective and well tolerated as amoxycillin in the treatment of acute maxillary sinusitis and bacteriological cure was achieved in 88% and 91% of evaluable patients for clarityromycin and amxycillin, respectively.
Archives of Otolaryngology - Head and Neck SurgeryComparative Evaluation of Cefuroxime Axetil and Cefaclor for Treatment of Acute Bacterial Maxillary Sinusitis
55 Citations1989Austin Sydnor, Jack M. Gwaltney +2 more
Among culture-positive sinuses, bacteriologic cure was achieved in 36 (95%) of 38 sinuses and 15 (71%) of 21 sinuses treated with cefuroxime axetil and cefaclor, respectively, and the overall frequencies of adverse events were similar between drugs.
Annals of Otology Rhinology & LaryngologyComparison of Subjective and Radiological Findings during the Course of Acute Maxillary Sinusitis
38 Citations1983Alf Axelsson, Ulf Runze
The cough symptom showed the slowest recovery subjectively and also compared most closely with radiological findings during the course of the disease, which demonstrated that the healing course during the first 15 treatment days follows an even regression line.
Current Medical Research and OpinionComparative efficacy and tolerability of clarithromycin and amoxycillin in the treatment of out-patients with acute maxillary sinusitis
37 Citations1990Evaldo Marchi
Clarithromycin was comparable to amoxycillin with respect to clinical efficacy and tolerability and offers a useful addition to the available therapies for the treatment of acute maxillary sinusitis.
Journal of Clinical EpidemiologyMethodological standards for assessing therapeutic equivalence
36 Citations1991Bram Kirshner
This paper reviews issues related to defining and demonstrating therapeutic equivalence and proposes guidelines to critically review clinical trials to determine whether there is sufficient evidence to conclude that an experimental therapy is therapeutically equivalent to a standard one.
OtolaryngologyTherapeutic approach to sinusitis: Antiinfectious therapy as the baseline of management
29 Citations1990Birgit Winther, Jack M. Gwaltney
Patients with acute, community-acquired sinusitis can usually be treated empirically, on the basis of previous studies, unless complications are suspected, and in that case, puncture of the involved sinus and aspiration of sinus fluid for Gram's staining and quantitative microbial cultures and sensitivities are required for appropriate antimicrobial management.
Antimicrobial Agents and ChemotherapyComparison of cyclacillin and amoxicillin for therapy for acute maxillary sinusitis
28 Citations1986W. Michael Scheld, Austin Sydnor +3 more
Cyclacillin appears equivalent to amoxicillin in the therapy of acute maxillary sinusitis and there was no correlation between clinical or bacteriologic cure and the results of sinus transillumination at follow-up.
Archives of Otolaryngology - Head and Neck SurgeryAcute Bacterial Sinusitis: Minocycline vs Amoxicillin
25 Citations1986Kenneth F. Mattucci, W. J. Levin +1 more
Minocycline and amoxicillin were equally safe and effective in the treatment of these patients with acute bacterial sinusitis.
Southern Medical JournalEvaluation of Cefixime in the Treatment of Bacterial Maxillary Sinusitis
19 Citations1993Brian L. Matthews, R I Kohut +8 more
Cefixime was effective in the treatment of bacterial sinus infections in adults and was well tolerated, and three patients discontinued therapy because of side effects.
PubMedBrodimoprim versus amoxicillin in the treatment of acute sinusitis.
15 Citations1992R. Nyffenegger, D. Riebenfeld +1 more
The results indicate that brodimoprim is safe and effective in the treatment of acute sinusitis in adults and the causative pathogen has been eradicated.
JAMAUse of Brand Names in Place of Generics
10 Citations1995Joseph H. Davis
I was surprised to find a medication referred to by its brand name, Tylenol, in the article by Dr Kogan and colleagues, and was advised to use the word acetaminophen when advising parents on using over-the-counter preparations.
European Journal of EpidemiologyAntimicrobial resistance among clinical isolates of Haemophilus influenzae in Northern Italy
6 Citations1993M.L. Garlaschi, Franca Rusconi +8 more
Strains isolated from adults were more susceptible to trimethoprim-sulfamethoxazole than strains isolated from children (85% vs 66%; p = 0.011) and more than 95% were susceptible to ampicillin, cefaclor and chloramphenicol.
