Highly <i>Z</i>‐Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol‐5‐ones Promoted by <i>N</i>,<i>N</i>′‐Dioxide–Metal Complexes
Angewandte Chemie International EditionPublished 3 February 2012
Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili Lin
Citations110
SJR quartileQ1
SJR score5.55
SNIP2.47
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TL;DR
The procedure tolerates a wide range of substrates to generate optically active pyrazolones with vinyl-substituted quaternary stereocenters and thermodynamically unstable (Z)-enone derivatives are obtained.
Abstract
Highly selective: the title reaction is achieved with high enantiomeric and geometric control and thermodynamically unstable (Z)-enone derivatives are obtained as the major products. The procedure tolerates a wide range of substrates to generate optically active pyrazolones with vinyl-substituted quaternary stereocenters.
Keywords
Chemistry
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