MK-801 inhibits the development of morphine tolerance at spinal sites
Brain ResearchPublished 1 October 1993Open access
Howard B. Gutstein, Keith A. Trujillo
Citations96
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
It is shown that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats, suggesting that NMDA receptor antagonists inhibit opiate tolerance at spinal sites and providing strong evidence that the effects are not due to its ability to interfere with associative learning.
Abstract
The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.
Keywords
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