A model for predicting mortality among critically ill burn victims
BurnsPublished 26 November 2008
Rita Galeiras, José A. Lorente, Sónia Pértega-Díaz, Alfonso Vallejo, Vinko Tomicić, Miguel A. de la Cal
Citations84
SJR quartileQ1
SJR score0.76
SNIP1.29
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In this model, MV and not inhalation injury is a mortality risk factor and age, total and full-thickness BSA burned, female gender and early mechanical ventilation were independently associated with mortality.
Abstract
We propose a mortality predictive equation for burned victims. In this model, MV and not inhalation injury is a mortality risk factor.
Keywords
MedicineHealth Professions
New England Journal of MedicineObjective Estimates of the Probability of Death from Burn Injuries
1,320 Citations1998Colleen M. Ryan, David Schoenfeld +4 more
The probability of mortality after burns is low and can be predicted soon after injury on the basis of simple, objective clinical criteria.
Annals of SurgeryThe Influence of Inhalation Injury and Pneumonia on Burn Mortality
616 Citations1987K Z Shirani, Basil A. Pruitt +1 more
It is indicated that inhalation injury and pneumonia have significant, independent, additive effects on burn mortality and that these effects vary with age and burn size in a predictable manner.
New England Journal of MedicineInitial Management of Burns
459 Citations1996William W. Monafo
The incidence of burn injury has declined steadily over the past several decades in the United States and in some other developed countries, and in-hospital fatality rates have also declined and are now only about 4 percent among patients with major injuries who are treated in specialized burn units.
Journal of Burn Care & RehabilitationRecent Outcomes in the Treatment of Burn Injury in the United States: A Report From the American Burn Association Patient Registry
340 Citations1995Jeffrey R. Saffle, Byron L. Davis +1 more
This article reports outcomes of 6417 patients treated during 1991-1993 in 28 burn centers by use of the ABA's computerized patient registry, finding no reliable method could be found to predict survival on admission.
Annals of SurgeryMortality Determinants in Massive Pediatric Burns
330 Citations1997Steven E. Wolf, J. Keith Rose +4 more
Mortality has decreased in massively burned children to the extent that nearly all patients should be considered as candidates for survival, regardless of age, burn size, presence of inhalation injury, delay in resuscitation, or laboratory values on initial presentation.
The Journal of Trauma: Injury, Infection, and Critical CareEFFECT OF INHALATION INJURY, BURN SIZE, AND AGE ON MORTALITY
304 Citations1994David Smith, Bruce A. Cairns +6 more
The presence of inhalation injury is significantly associated with mortality after thermal injury but adds little to the prediction of mortality using %TBSA and age alone, while using multivariate analysis inhalation Injury was found to be an important variable in determining outcome.
Journal of the American College of SurgeonsAn Evaluation of Risk Factors for Mortality After Burn Trauma and The Identification of Gender-Dependent Differences in Outcomes
265 Citations2001Grant E. O’Keefe, John L. Hunt +1 more
It is expected that future advances in burn trauma research will require careful and ongoing quantification of mortality risk factors to measure the importance of newly identified factors and to determine the impact of new therapies.
World Journal of SurgeryBurn depth: A review
259 Citations1992David M. Heimbach, Loren H. Engrav +2 more
This review summarizes the considerable literature in which a variety of techniques to determine burn depth have been used in order to accurately determine which dermal burns to excise and graft.
BurnsRespiratory management of inhalation injury
253 Citations2007Ronald P. Mlcak, Oscar E. Suman +1 more
Inhalation injury has now become the most frequent cause of death in burn patients and a well organized, protocol driven approach to respiratory care of inhalation injury is needed so that improvements can be made and the morbidity and mortality associated with inhalation injuries be reduced.
The Journal of Trauma: Injury, Infection, and Critical CareEffect on Mortality of Inhalation Injury
253 Citations1986Paul Thompson, David N. Herndon +2 more
The incidence of and mortality from inhalation injury both rose with increasing burn area and also rose with advancing age; mortality was lowest in the 5- to 14-year old age group and highest in those more than 59 years of age.
BurnsOutcome measures in burn care
197 Citations2004Clifford T. Pereira, Kevin D. Murphy +1 more
The outcome measures in the acute phase of burn management (mortality and morbidity from the post-burn hypermetabolic response) are reviewed and long-term outcome measures that are now becoming of equal importance as the numbers of burn survivors increase are discussed.
Annals of SurgerySurvival Benefit in Critically Ill Burned Patients Receiving Selective Decontamination of the Digestive Tract
193 Citations2005Miguel A. de la Cal, Enrique Cerdá +5 more
Treatment with SDD reduces mortality and pneumonia incidence in patients with severe burns and was associated with a significant reduction in mortality both in the burn ICU and in the hospital.
Intensive Care MedicineOutcome and changes over time in survival following severe burns from 1985 to 2004
188 Citations2005Nele Brusselaers, Eric A. J. Hoste +5 more
Global mortality following burns is low, and nearly all patients who die had at least one risk factor present, and survival following severe burns has continued to improve.
British journal of surgeryDeterminants of death following burn injury
167 Citations2001Matthias Müller, Stuart P. Pegg +1 more
Whether changes in management have improved survival following burn injury and to determine the contributory factors leading to non‐survival are established.
BurnsThe impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission-scoring systems
163 Citations1997G. Germann, U. Barthold +3 more
It can be concluded that risk factors and pre-existing conditions have a significant impact on the prognosis of burn mortality and should be incorporated into further refinements of burn admission scores.
The Journal of Trauma: Injury, Infection, and Critical CarePredicting Increased Fluid Requirements During the Resuscitation of Thermally Injured Patients
161 Citations2004Leopoldo C. Cancio, Saturnino Ch vez +5 more
Burn size and weight (negatively) were associated with greater VOL, however, a close linear relationship between burn size and VOL was not observed, and mechanical ventilation supplanted TBSA by 24 hours as a predictor of high VOL.
Annals of SurgeryThe Role of Inhalation Injury in Burn Trauma A Canadian Experience
148 Citations1990Edward E. Tredget, Heather A. Shankowsky +3 more
The data demonstrate that Inhalation injury is an important comorbid factor in burn injury that increases the number of deaths substantially and also independently prolong the duration of hospitalization in a highly unpredictable fashion as compared to patients with cutaneous burns only.
BurnsEpidemiological and outcome characteristics of major burns in Tokyo
142 Citations2004K. Kobayashi, Hiroto Ikeda +12 more
The mortality rate showed mildly decreasing tendency since 1995 for which implementation of skin bank was thought to be responsible, and the burn size and inhalation injury were the factors for high mortality rate in all age groups.
Annals of SurgeryMultifactorial Probit Analysis of Mortality in Burned Patients
141 Citations1979Bruce E. Zawacki, Stanley P. Azen +2 more
Journal of Burn Care & ResearchSex Differences in Mortality After Burn Injury: Results of Analysis of the National Burn Repository of the American Burn Association
137 Citations2006Jeffrey D. Kerby, Gerald McGwin +4 more
This study confirmed earlier studies showing an association between sex and burn mortality, and analyzed differences in immune responses between men and women after burn injury to provide insight into the mechanism behind these divergent outcomes and identify targets for future therapy.
BurnsInfluence of demographics and inhalation injury on burn mortality in children
136 Citations2003Robert E. Barrow, Marcus Spies +2 more
Inhalation injury remains one of the primary contributors to burn mortality in burned children, however, children under the age of 3 years are at a higher risk both with and without inhalation injury.
The American Journal of SurgeryEtiology and consequences of respiratory failure in thermally injured patients
130 Citations1993Timothy C. Hollingsed, Jeffrey R. Saffle +3 more
It is demonstrated that respiratory failure, regardless of its cause, frequently leads to multiple organ failure and death in burn patients and inhalation injury, in the absence of respiratory Failure, does not appear to contribute to mortality.
The Journal of Trauma: Injury, Infection, and Critical CareTen Year Experience of Burn, Trauma, and Combined Burn/Trauma Injuries Comparing Outcomes
119 Citations2004John M. Santaniello, Fred A. Luchette +5 more
B combined with T presents a rare injury pattern that has a synergistic effect on mortality, and Physicians and caregivers should be aware of a 2-3 fold increase in the incidence of INH in this population, and increased mortality despite similar TBSA burned when compared with patients with B as the sole mechanism.
World Journal of SurgerySmoke inhalation: Diagnosis and treatment
86 Citations1992William R. Clark
The early lesions of smoke inhalation often progress in the context of sepsis and other complications of the burn illness to a clinical state consistent with adult respiratory distress syndrome, suggesting that thermal injury or its treatment is responsible for further lung damage.
BurnsRevised estimates of mortality from burns in the last 20 years at the Birmingham Burns Centre
78 Citations2001Abid Rashid, Atul Khanna +2 more
It is concluded that in the experience the chances of dying for a given severity of injury have not changed significantly for more than 20 years.
Journal of Burn Care & ResearchFactors Affecting Prognosis of Inhalation Injury
73 Citations2006David A. Edelman, Michael White +2 more
The mortality rate and length of stay appear to be increased primarily by the severity of the associated burn in patients with inhalation injury andburns.
BurnsPrognostic implications of inhalation injury in burn patients in Tokyo
69 Citations2005Masaru Suzuki, Naoki Aikawa +2 more
In conclusion, inhalation injury was the most important predictor of overall mortality among burned patients in Tokyo.
Annals of SurgeryEnteral Vancomycin Controls Methicillin-resistant Staphylococcus Aureus Endemicity in an Intensive Care Burn Unit
69 Citations2007Enrique Cerd, A. Abella +6 more
Enteral vancomycin is an effective and safe method to control MRSA in intensive care burn units without VRE and there was no emergence of either vancomYcin-resistant enterococci or Staphylococcus aureus with intermediate sensitivity to glycopeptides in period 2.
Journal of Burn Care & RehabilitationThe Association Between Sex and Mortality Among Burn Patients as Modified by Age
64 Citations2005Richard L. George, Gerald McGwin +5 more
It is indicated that women have an increased odds of mortality after thermal injury and a differential effect of age on the association between sex and mortality, as well as investigated the impact of sex hormones on mortality among burn patients.
Critical Care MedicineNew clinically relevant sheep model of severe respiratory failure secondary to combined smoke inhalation/cutaneous flame burn injury
62 Citations2000Scott K. Alpard, Joseph B. Zwischenberger +4 more
A combination of 36 breaths of smoke and a 40% total body surface area (third‐degree) cutaneous flame burn injury can induce severe RDS (PaO2/FIO2 <200) within 40‐48 hrs to allow evaluation of various treatment modalities of RDS.
Journal of Burn Care & RehabilitationSmoke Inhalation and Airway Management at a Regional Burn Unit
62 Citations1989William R. Clark, María Marta Bonaventura +1 more
Victims of smoke inhalation with and without burns and burn patients with respiratory insufficiency for reasons other than smoke at a regional burn unit are profiled in terms of age, burn size, length of stay, and mortality.
The Journal of Trauma: Injury, Infection, and Critical CareOperative Indications in Penetrating Renal Trauma
62 Citations1985Peter R. Carroll, Jack W. McAninch
A review of 53 patients with penetrating renal injuries treated between 1978 and 1983 at San Francisco General Hospital correlated several factors with the extent of renal damage to determine whether major and minor injuries could be differentiated preoperatively, thereby avoiding unnecessary surgical exploration.
The Journal of Trauma: Injury, Infection, and Critical CareCauses of Death and Predictors in Burned Patients More than 60 Years of Age
62 Citations1986Maher M. Anous, David M. Heimbach
The Journal of Trauma: Injury, Infection, and Critical CareAssessment of Severity of Ovine Smoke Inhalation Injury by Analysis of Computed Tomographic Scans
58 Citations2003MAJ Myung S. Park, LTC Leopoldo C. Cancio +6 more
At 24 hours, CT scanning enabled SII severity stratification; qualitative evaluation (RADS) outperformed current semiautomated methods (DENS, FALT), and ordinary logistic regression generated a predictive model for severity of injury.
Critical Care MedicineSystemic hemodynamics, gastric intramucosal Pco2 changes, and outcome in critically ill burn patients
51 Citations2000José A. Lorente, A.I. Ezpeleta +7 more
There are hemodynamic and biochemical changes that occur early after burn trauma that are associated with prognosis after an apparently successful resuscitation, and particularly, a hemodynamic profile characterized by systemic acidosis, low systemic blood flow, and systemic and pulmonary vasoconstriction early after trauma is associated with a poor outcome.
BurnsAcute physiology, age, and chronic health evaluation (APACHE) III score is an alternative efficient predictor of mortality in burn patients
44 Citations2006Yohei Tanaka, Mikio Shimizu +1 more
It is suggested that APACHE III score could be used as an alternative efficient predictor of mortality in burn patients and showed a significant correlation with PBI (p<0.0001).
PubMedOutcome analysis of 286 severely burned patients: retrospective study.
43 Citations2002W S Ho, S.Y Ying +1 more
A predictive model for mortality and length of hospital stay has been developed for major burn patients in Hong Kong that may help clinicians to counsel patients and relatives at an early stage of care, to provide a basis from which new treatment plans can be compared, and to facilitate efficient allocation of valuable medical resources.
BurnsBurns mortality and hospitalization time — a prospective statistical study of 352 patients in an Asian National Burn Centre
37 Citations1995Merng Koon Wong, R C Ngim
A prospective study of 352 patients in an Asian National Burn Centre has been used to develop statistical predictive models for mortality and hospitalization time and these models will serve as baseline standards for evaluation of new therapies, assist in the allocation of resources and identifying the at-risk population for improvements in therapy.
The Journal of Trauma: Injury, Infection, and Critical CareDevelopment and Validation of an Age-Risk Score for Mortality Predication after Thermal Injury
36 Citations2005Aimee R. Moreau, Peter H. Westfall +2 more
AGESCORE provided an accurate method for modeling mortality in burn patients across different age groups, burn sizes, eras, and burn centers and benefits of a standardized index of age risk include ease of comparison, reduction of bias, and increased efficiency attributable to statistical parsimony.
The Journal of Trauma: Injury, Infection, and Critical CareFACTORS SIGNIFICANTLY AFFECTING MORTALITY IN THE BURNED PATIENT
34 Citations1965Max S. Rittenbury, Fred Schmidt +4 more
BurnsPredicting factors influencing the fatal outcome of burns in Kuwait
32 Citations2005Prem N. Sharma, Prem N. Sharma +6 more
A prospective study on burn patients admitted at the Burn Center in Kuwait during 1993 to 2001 revealed a fatal outcome associated with gender and cause of burn, and patients with these characteristics need to be given special attention during in-patient care.
BurnsFactors involved in burn mortality: A multivariate statistical approach based on discriminant analysis
32 Citations1992Pasquale De Vico, J Papillon
Discriminant analysis allowed us to demonstrate an impressive correlation between death, age and TBSA; inhalation injury by itself and sex, the two other significant factors in this study, seem to have a minor influence on the final outcome of the burned patients and their predictive value is virtually nil.
Eastern Mediterranean Health JournalPredictive models for mortality and length of hospital stay in an Egyptian burns centre
27 Citations2000Amani Attia
Total surface area burnt, inhalation burns, age, sex, depth and degree of burn wounds were the significant independent predictors of mortality in multiple logistic regression analysis and the length of hospital stay was clothing ignition.
Annales de Chirurgie Plastique EsthétiqueÉvaluation des facteurs pronostiques chez le patient brûlé
21 Citations2001O Griffe, Rune Gärtner +5 more
Le pouvoir predictif de la surface de brulures profondes (SBP) est superieur a celui de the surface totale brulee qui est pourtant retenu dans la plupart des etudes precedentes.
ShockTHE SEQUENCE OF INJURY DETERMINES THE DEGREE OF LUNG DAMAGE IN BOTH INHALATION AND THERMAL INJURIES
17 Citations1994Naoaki Matsumoto, Hiroshi Noda +4 more
Lung damage is minimized when thermal injury precedes smoke inhalation injury, and lung lymph flow and wet/dry weight ratio were significantly higher in smoke before burn group animals.