Thrombocytopenia Occurring During the Administration of Heparin
Annals of Internal MedicinePublished 1 August 1976
William R. Bell, PETER A. TOMASULO, BARBARA M. ALVING, THOMAS P. DUFFY
Citations251
SJR quartileQ1
SJR score3.38
SNIP3.27
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TL;DR
In a group of 52 patients receiving continuous intravenous heparin, 16 developed thrombocytopenia (platelets less than 100 000/mm3), and five of these 10 patients also had a reduction in plasma fibrinogen.
Abstract
In a group of 52 patients receiving continuous intravenous heparin, 16 developed thrombocytopenia (platelets less than 100 000/mm3). Ten of the 16 patients who had thrombocytopenia had elevated titers of fibrinogen-fibrin degradation products, and five of these 10 patients also had a reduction in plasma fibrinogen. The abnormalities disappeared after the heparin preparation was discontinued. These occurrences could not be attributed to drugs other than heparin, to the dose of heparin administered, or to prior exposure to heparin. The mechanism by which the heparin preparation may induce these changes is not known.
Keywords
Medicine
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