Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes
PsychopharmacologyPublished 1 January 1982
Sture Liljequist, J�rgen Engel
Citations254
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
The results from the present series of experiments indicate that ethanol enhances central GABAergic activity.
Abstract
The interaction between ethanol and various GABAergic drugs (muscimol, bicuculline, picrotoxin) with regard to their effects on locomotor activity, drug-induced sleep, body temperature, and convulsions was studied. It was demonstrated that the GABA receptor agonist muscimol potentiated the sedative properties of ethanol, while the opposite effect, a reduction of ethanol-produced sedation, was seen upon administration of the GABA receptor blocking agent picrotoxin. Consequently, the results from the present series of experiments indicate that ethanol enhances central GABAergic activity.
Keywords
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