Interleukin-3 supports growth of mouse pre-B-cell clones in vitro
NaturePublished 1 May 1984
Ronald Palacios, Geoffrey Henson, Michael Steinmetz, John P. McKearn
Citations230
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
It is described here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleuko-3 dependent pre- B-cell clones that can be induced to mature into antibody secreting cells in vitro.
Abstract
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro.
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology
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