The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro
Neuroscience LettersPublished 1 August 1991
Uwe Frey, Henry Matthies, Klaus G. Reymann, Hansjürgen Matthies
Citations317
SJR quartileQ2
SJR score0.77
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 microM during tetanization with 3 trains of 100 impulses resulted in a prevention of late LTP stages (greater than 1-2 h).
Abstract
The effect of dopaminergic D1 receptor blockade on the expression of long-term potentiation (LTP) was investigated in the rat hippocampal CA1 region in vitro by extracellular recordings (by measuring the population spike amplitude and the field EPSP). The presence of the very selective D1 receptor blocker SCH 23390 at a concentration of 0.1 microM during tetanization with 3 trains of 100 impulses (100 Hz) resulted in a prevention of late LTP stages (greater than 1-2 h). When SCH 23390 was added to the bath medium immediately after tetanization, an influence on established LTP could not be observed during the first 3 h investigated.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
Trends in NeurosciencesNMDA receptors - their role in long-term potentiation
1,181 Citations1987Graham L. Collingridge, Tim Bliss
The recent evidence that has revealed the pivotal role of NMDA receptors in the induction of LTP is described, and the possible mechanisms involved in the maintenance of the potentiated state are discussed.
Annual Review of NeuroscienceLong-Term Potentiation
802 Citations1987Timothy J. Teyler, Pascal DiScenna
The available evidence suggests that L TP does occur in conjunction with behavioral learning-although whether it is necessary and sufficient is far from certain.
Brain ResearchAnisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro
795 Citations1988Uwe Frey, Manfred Krug +2 more
A late PS potentiation of a second non-tetanized pathway to CA1 pyramidal cells has been observed for the first time and suggests that the maintenance of LTP is dependent on a postsynaptic mechanism.
The Journal of PhysiologyLong‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency.
472 Citations1978Thomas V. Dunwiddie, Gary Lynch
The results suggest that potentiated and heterosynaptic depression arise from different mechanisms, and that potentiation is confined to the set of terminals activated by a conditioning train, whereas the depression is generalized to the whole neurone.
Proceedings of the National Academy of SciencesMolecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
457 Citations1990Frederick J. Monsma, L C Mahan +3 more
In order to clone the D1 dopamine receptor linked to adenylyl cyclase activation, the polymerase chain reaction was used with highly degenerate primers to selectively amplify a cDNA sequence from NS20Y neuroblastoma cell mRNA, exhibiting considerable sequence homology to guanine nucleotide-binding (G)-protein-coupled receptors that have been cloned previously.
NatureNMDA application potentiates synaptic transmission in the hippocampus
422 Citations1988Julie A. Kauer, Robert C. Malenka +1 more
This model predicts that application of a large depolarizing dose of NMDA should be sufficient to evoke long-term potentiation, and proposes that LTP has two components, a short-term, decremental component which can be mimicked by NMDA receptor activation, and a long-lasting, non-decremental components which, in addition to requiring activation ofNMDA receptors, requires stimulation of presynaptic afferents.
NeuroscienceD2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
341 Citations1990Mike Dragunow, George S. Robertson +3 more
The results of time-course immunocytochemical and antiserum studies suggest that some striatal neurons express c-fos protein-related antigens but not c- fos protein after haloperidol injection, and theories concerning the biochemical mechanism of action of haloperIDol are discussed.
Brain ResearchDopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices
334 Citations1990Uwe Frey, Helmut Schröeder +1 more
The observations suggest that dopaminergic influences during and immediately after tetanization at least additionally contribute to the induction of postsynaptic mechanisms subserving a late, long-lasting maintenance of potentiation.
The Journal of PhysiologyReduction of long‐term potentiation in the dentate gyrus of the rat following selective depletion of monoamines.
293 Citations1983T.V.P. Bliss, Graham V. Goddard +1 more
Results show that monoamines can modulate long‐term changes in synaptic function in the dentate gyrus, and suggest that 5‐HT is more potent in this respect than NA, and the effect of monoamine depletion on granule cell excitability was investigated.
Brain ResearchAgonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of long-term potentiation in slices of rat visual cortex
275 Citations1992S. Bröcher, Alain Artola +1 more
It is suggested that the agonists of both receptor systems enhanced the depolarizing response to the tetanus and increased NMDA receptor-gated conductances during this response also accounts for the facilitatory effects which ACh and NA have on use-dependent synaptic plasticity in the developing visual cortex.
Neuroscience LettersLong-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats
188 Citations1989Mike Dragunow, Wickliffe C. Abraham +4 more
Neuroscience LettersMuscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus
185 Citations1990Edward C. Burgard, John M. Sarvey
Activation of M1 receptors can facilitate the induction of LTP, and bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices.
Brain ResearchPolymyxin B, an inhibitor of protein kinase C, prevents the maintenance of synaptic long-term potentiation in hippocampal CA1 neurons
178 Citations1988Klaus G. Reymann, Uwe Frey +2 more
Results provide direct evidence that the PKC activation is not essential for the initial phase of LTP, but is a necessary condition for a medium and a late, protein synthesis-dependent phase in this monosynaptic pathway, i.e. for the maintenance of synaptic LTP.
Experimental Brain ResearchA role for N-methyl-D-aspartate receptors in norepinephrine-induced long-lasting potentiation in the dentate gyrus
87 Citations1989Patric K. Stanton, István Módy +1 more
The results suggest that granule cell influx of Ca2+ through NMDA ionophores is enhanced by NE via β-receptor activation, which suggests that NE induction of long- term, but not short-term, plasticity in the dentate gyrus requires NMDA receptor activation.
Brain ResearchNaloxone blocks the induction of long-term potentiation in the lateral but not in the medial perforant pathway in the anesthetized rat
84 Citations1988Clive R. Bramham, M.L. Er̀rington +1 more
It is suggested that activation of naloxone-sensitive receptors is necessary for the full expression of LTP in the lateral perforant pathway.
Brain Research BulletinThe duration of long-term potentiation in the CA1 region of the hippocampal slice preparation
67 Citations1985Klaus G. Reymann, Reinhard Malisch +4 more
The slice preparation is proposed that the investigation of mechanisms of a postulated late phase of LTP if appropriate conditions are used and the smaller field-EPSP values necessary to evoke near-threshold pop-spikes demonstrate an E-S potentiation (left-shift) at least in the low-intensity range.
Neuroscience Letters2-Amino-4-phosphonobutyrate selectively eliminates late phases of long-term potentiation in rat hippocampus
65 Citations1989Klaus G. Reymann, Hansjuergen Matthies
Data suggest that besides the obligatory NMDA receptor activation an APB-sensitive component expressed during and after tetanization is a necessary step for subsequent mechanisms enabling the late maintenance of LTP.
European Journal of NeuroscienceActivation of a K‐252b‐Sensitive Protein Kinase is Necessary for a Post‐Synaptic Phase of Long‐Term Potentiation in Area CA1 of Rat Hippocampus
51 Citations1990Klaus G. Reymann, S.N. Davies +3 more
K‐252b, a potent inhibitor of protein kinases blocked a late phase of long‐term potentiation in area CA1 of rat hippocampal slices, resulting in decremental LTP, and may be involved in a slowly developing postsynaptic component of LTP.
Neuroscience LettersTransient increase of raf protein kinase-like immunoreactivity in the rat dentate gyrus during long-term potentiation
32 Citations1990András Mihály, Zoltán Oláh +5 more
The induction of long-term potentiation in the dentate fascia of freely-moving rats triggered the appearance of raf-1-like staining and increased the number of granule cells with pan-raf-like immunoreactivity.
Brain Research BulletinA new microcirculation chamber for inexpensive long-term investigations of nervous tissue in vitro
16 Citations1986W. Thiemann, Reinhard Malisch +1 more
The construction of a simple universal chamber for long-term recording from submerged and interface brain slices is described, which permits experiments which require long- term exposure to expensive drugs as well as great economy of oxygen consumption.