Comparison of ventricular pressure relaxation assessments in human heart failure
Journal of the American College of CardiologyPublished 1 November 1999
Hideaki Senzaki, Barry Fetics, Chen-Huan Chen, David A. Kass
Citations81
SJR quartileQ1
SJR score9.02
SNIP6.30
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Relaxation consistently deviates from an ME decay in DCM resulting in instability and amplified relaxation systolic load or drug dependence of ME-based indexes in failing versus control (or HCM) hearts. The hybrid-logistic method improves quantitative analyses by providing more consistent data fits with all three heart types.
Keywords
Medicine
Journal of Clinical InvestigationHemodynamic determinants of the time-course of fall in canine left ventricular pressure.
1,083 Citations1976James L. Weiss, James W. Frederiksen +1 more
The present studies show that the time-course of isovolumic pressure fall subsequent to maximum negative dP/dt is exponential, independent of systolic stress and end-systolic fiber length, and minimally dependent on heart rate.
Circulation ResearchVolume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart.
445 Citations1981Gilbert Raff, Stanton A. Glantz
Volume loading slows isovolumic relaxation rate in the intact canine heart and appears to be a reflection of the dependence of relaxation on both end-diastolic and mean aortic systolic pressures.
New England Journal of MedicineDiastolic Dysfunction in Congestive Heart Failure
352 Citations1991William Grossman, Lisa H. Underhill +1 more
The terms "heart failure" and "congestive heart failure" are often used interchangeably, emphasizing the importance of congestion in the clinical presentation of patients with heart failure.
American Journal of Physiology-Heart and Circulatory PhysiologyLeft ventricular relaxation in the filling and nonfilling intact canine heart
227 Citations1986Edward L. Yellin, Masatsugu Hori +4 more
Left ventricular relaxation in the filling and transiently nonfilling working hearts of seven open-chest pentobarbital-anesthetized dogs is studied by totally occluding the mitral annulus during one systole to evaluate the validity of a monoexponential characterization of relaxation.
CirculationAre contraction and relaxation coupled in patients with and without congestive heart failure
140 Citations1992E JEichhorn, J EWillard +5 more
CirculationAre contraction and relaxation coupled in patients with and without congestive heart failure?
138 Citations1992Eric J. Eichhorn, J E Willard +5 more
CirculationMarked Discordance Between Dynamic and Passive Diastolic Pressure-Volume Relations in Idiopathic Hypertrophic Cardiomyopathy
136 Citations1996Peter H. Pak, W L Maughan +2 more
The large disparity between flat pressure-volume relations during filling and steep end-diastolic relations appears unique to HCM indicates that caution should be used in the interpretation of stiffness results derived from steady-state data and suggests that therapies that alter cavity geometry and/or reduce interaction may markedly influence LV diastolic pressures in HCM.
CirculationLogistic Time Constant of Isovolumic Relaxation Pressure–Time Curve in the Canine Left Ventricle
131 Citations1995Hiromi Matsubara, Miyako Takaki +3 more
It is concluded that the logistic model better fits LV isovolumic relaxation P(t) than the monoexponential model in the present heart preparation and is proposed as a better alternative to TE for evaluating LV lusitropism.
CirculationImpaired early left ventricular relaxation in coronary artery disease: effects of intracornary nifedipine.
123 Citations1980Michel F. Rousseau, C. Veriter +3 more
At rest, impairment of isovolumic relaxation in CAD patients is mainly limited to the first 40 msec after peak (negative) dP/dt, suggesting a dyssynchronous wall motion.
CirculationEffects of beta-adrenergic stimulation with dobutamine on isovolumic relaxation in the normal and failing human left ventricle.
108 Citations1991John D. Parker, Joel S. Landzberg +3 more
These data demonstrate that beta-adrenergic receptor stimulation causes significant acceleration of LV isovolumic relaxation in both normal subjects and patients with severe CHF, demonstrating well preserved lusitropic response to beta- adrenergic stimulation despite substantial attenuation of the positive inotropic response.
CirculationNonuniform course of left ventricular pressure fall and its regulation by load and contractile state.
102 Citations1994Adelino Leite‐Moreira, Thierry Gillebert
Effects of elevations in systolic LVP on rate of LVP fall could be predicted by knowing peak isovolumetric LVP, and the contraction-relaxation coupling should be analyzed in terms of peak force development rather than contraction velocity or ejection fraction.
CirculationRelaxation–Systolic Pressure Relation
96 Citations1997Thierry Gillebert, Adelino Leite‐Moreira +1 more
Assessment of contractility with systolic LVP-relaxation relation is precise and load independent and can be performed with the sole use of a high-fidelity pressure gauge positioned in the left ventricular cavity.
CirculationAcute Cardiovascular Effects of OPC-18790 in Patients With Congestive Heart Failure
79 Citations1996Marc D. Feldman, Peter H. Pak +9 more
OPC-18790 has potent venous and arterial vasodilator effects and moderate inotropic and lusitropic effects without a change in heart rate and these combined actions suggest a unique potential of OPC- 18790 for heart failure treatment.
Journal of Molecular MedicineCalcium transport proteins in the nonfailing and failing heart: gene expression and function
59 Citations1995Michael Wankerl, K Schwartz
The proteins involved in myocardial Ca2+ handling are discussed and the current state of research on expressional and functional alterations and their potential implication in the pathomechanism of heart failure is described.
Journal of Cardiovascular PharmacologyDisparate Inotropic and Lusitropic Responses to Pimobendan in Conscious Dogs with Tachycardia-Induced Heart Failure
52 Citations1994Hidetsugu Asanoi, Shinji Ishizaka +3 more
Pimobendan accelerated LV isovolumic relaxation and improved distensibility in conscious dogs with tachycardia-induced heart failure despite the marked attenuation of inotropic responses.
CirculationLoading Sequence Plays an Important Role in Enhanced Load Sensitivity of Left Ventricular Relaxation in Conscious Dogs With Tachycardia-Induced Cardiomyopathy
49 Citations1995Shinji Ishizaka, Hidetsugu Asanoi +3 more
CirculationEffects of beta-adrenergic stimulation with dobutamine on isovolumic relaxation in the normal and failing human left ventricle.
38 Citations1991J DParker, J SLandzberg +3 more
CirculationThe dependence of the time constant of left ventricular isovolumic relaxation (tau) on pericardial pressure.
32 Citations1990Michael A. Frais, Dale W. Bergman +4 more
Both the time constant and the asymptotes of tau seem to indicate the same baseline pressure, a pressure that increases pari passu with pericardial pressure.
PubMedThe hemodynamic manifestation of normal myocardial relaxation. A framework for experimental and clinical evaluation.
30 Citations1997Thierry Gillebert, Adelino Leite‐Moreira +1 more
Comparison of clinical and experimental data during manipulation of afterload should lead to an improved understanding of clinical relaxation disturbances and to a therapeutic approach, which is relevant from the physiopathological point of view.
The Japanese Journal of PhysiologyLogistic Characterization of Left Ventricular Isovolumic Pressure-Time Curve.
25 Citations1995Hiromi Matsubara, Junichi Araki +3 more
This study hypothesized that a ventricular isovolumic pressure-time curve could be expressed as the difference between two S-shaped curves for pressure rising and falling, and proposed a new "hybrid logistic" function to express it.
HeartEarly diastolic left ventricular inflow pressures in normal subjects and patients with dilated cardiomyopathy. Reconstruction from pulsed Doppler echocardiography.
8 Citations1995S Fujimoto, K. H. Parker +3 more
Total early diastolic positive and negative peak pressure drop are normally low, so that significant negative left ventricular pressures are not needed to explain normal resting early diastsolic mitral flow velocities.
American Journal of Physiology-Heart and Circulatory PhysiologyAn analysis of variability of left ventricular pressure decay
7 Citations1993Gregory L. Freeman, Sumanth D. Prabhu +2 more
It is concluded that LV pressure decay shows marked variability, unrelated to the algorithm used to assess it, and Ravg, a model independent parameter, may be a useful way to quantify LV pressure fall.