Cocarcinogenic effects of alcohol in hepatocarcinogenesis
GutPublished 1 July 2002Open access
Felix Stickel, Detlef Schuppan, Eckart G. Hahn, Helmut K. Seitz
Citations153
SJR quartileQ1
SJR score8.87
SNIP4.79
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TL;DR
A number of possible cofactors and mechanisms are discussed by which alcohol may enhance the development of hepatoma, including dietary or environmental carcinogens ingested along with alcoholic beverages, alcoholic cirrhosis as a precancerous condition, and the effects of alcohol metabolism.
Abstract
Alcohol is a major aetiological factor in hepatocarcinogenesis but our understanding of its importance as a modulating factor is just beginning to emerge. In the present review, a number of possible cofactors and mechanisms are discussed by which alcohol may enhance the development of hepatoma. These include dietary or environmental carcinogens ingested along with alcoholic beverages, alcoholic cirrhosis as a precancerous condition, and the effects of alcohol metabolism.
Keywords
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International Journal of CancerLack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma
43 Citations1997Hyo‐Suk Lee, Jung‐Hwan Yoon +4 more
There is a lack of association of the polymorphisms of CYP2E1 with the risk of HCC in humans with and without chronic alcohol ingestion, and there was no significant association between HCC risk and genotypes c1/c2 and c2/ c2 either in all H CC patients or in HCC patients of different ethnic groups.
PubMedGenomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy.
41 Citations1993Rosa M. Pascale, M M Simile +1 more
Modulation of rat liver carcinogenesis by influencing gene expression through DNA methylation or other epigenetic mechanisms could be a new approach to chemoprevention of these tumors.
HepatologyChronic Alcoholism Enhances Hepatocarcinogenicity of Diethylnitrosamine in Rats Fed A Marginally Methyl–Deficient Diet
40 Citations1985Eduardo A. Porta, Nalani Markell +1 more
Results indicate that chronic ethanol consumption enhances the hepatocarcinogenic and renal tumorigenic activity of diethylnitrosamine, and strongly suggest that this action is mediated through the accentuation of methyl deficiency.
Alcohol and AlcoholismHepatitis C Virus Infection in Alcoholic Liver Cirrhosis in Japan: Its Contribution to the Development of Hepatocellular Carcinoma
39 Citations1993Happei Miyakawa, Chifumi Sato +9 more
Although alcohol alone may not become a risk factor for HCC, it may potentiate the development of HCC caused by HCV, which is considered to be the highest risk group; strict abstinence is necessary for these patients.
AlcoholThe relationship of ethanol feeding to the methyl folate trap
38 Citations1993Anthony J. Barak, Harriet C. Beckenhauer +4 more
Proceedings of The Society for Experimental Biology and MedicineInhibition of Ethanol‐Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole
35 Citations2000Z.‐Q. Gouillon, Danièle Lucas +8 more
Results support the conclusion that chlormethiazole treatment partially protects the liver from injury by inhibiting CYP2E1 activity in vivo.
European Journal of Cancer PreventionViruses and alcohol in the pathogenesis of primary hepatic carcinoma
33 Citations2001Hiroshi Inoue, Helmut K. Seitz
The purpose of this review is briefly to discuss the link between HCV and HBV infection and HCC, some pathogenic aspects and also the role of alcohol in the development of HCC.
Alcoholism Clinical and Experimental ResearchEffects of Ethanol Consumption on Enriched Natural Killer Cells from C57BL/6 Mice
33 Citations1994Randle M. Gallucci, Linda J. Mister +1 more
Data indicate that in vitro cytolytic activity of NK cells from ethanol-consuming mice is inhibited in the absence of other modulatory leukocytes.
Alcohol and AlcoholismLONG-TERM CANCER RISK IN ALCOHOLISM
33 Citations1988P Prior
Although in women there was no overall excess of cancers, the risk was high in the biliary system (15-fold) and was moderately increased for cervix uteri (4-fold), and the cancer risk in men was increased 1.7-fold.
Journal of Cancer Research and Clinical OncologyEffect of chronic alcohol consumption on tumor incidence due to dimethylnitrosamine administration
32 Citations1983Rolf Teschke, Manfred Minzlaff +2 more
Chronic treatment with an alcohol-containing diet was shown to significantly improve the mean survival time of DMN-treated rats compared with identically treated animals fed the control diet, but the total number of tumors observed under these experimental conditions and the target organ remained virtually unchanged.
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