Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
The LancetPublished 1 October 2000
Christopher E. Brightling, William Monteiro, Richard J. Ward, Debbie Parker, Michael Morgan, Andrew J. Wardlaw
Citations590
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
It is suggested that eosinophilic airway inflammation contributes to airflow obstruction and symptoms in some patients with COPD and that the short-term effects of prednisolone are due to modification of this feature of the inflammatory response.
Abstract
Our findings suggest that eosinophilic airway inflammation contributes to airflow obstruction and symptoms in some patients with COPD and that the short-term effects of prednisolone are due to modification of this feature of the inflammatory response. The possibility that sputum eosinophilia identifies a subgroup of patients who particularly respond to long-term treatment with inhaled corticosteroids should be investigated.
Keywords
Medicine
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