The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1
CellPublished 1 June 1989
John H. Doonan, N. Ronald Morris
Citations324
SJR quartileQ1
SJR score22.61
SNIP7.62
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TL;DR
It is concluded that dephosphorylation of a key protein(s) is required to complete mitosis in Aspergillus nidulans and that the wild-type gene encodes a type 1 protein phosphatase.
Abstract
In Aspergillus nidulans, the temperature-sensitive, recessive cell cycle mutation bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei. We have shown that this mutation has an abnormally high content of nuclear phosphoproteins and that the wild-type gene encodes a type 1 protein phosphatase. We conclude that dephosphorylation of a key protein(s) is required to complete mitosis.
Keywords
Biochemistry, Genetics and Molecular Biology
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