The ErbB signaling network: receptor heterodimerization in development and cancer
The EMBO JournalPublished 3 July 2000Open access
Monilola A. Olayioye, Richard M. Neve, Heidi A. Lane, Nancy E. Hynes
Citations2,439
SJR quartileQ1
SJR score4.82
SNIP1.93
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TL;DR
The role of ErbB receptors as normal signal transducers and their contribution to the process of malignant transformation during tumor development are concentrated on.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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PubMedDynamic expression and activation of ERBB receptors in the developing mouse mammary gland.
162 Citations1998Joyce A. Schroeder, David C. Lee
Combined RNA and protein analyses of glands in different stages from virgin to involution revealed differential expression of the four ERBB receptors, as well as distinctive patterns of ERBB ligand expression that suggested specialized function.
Journal of Biological ChemistryPhosphotyrosine 1173 Mediates Binding of the Protein-tyrosine Phosphatase SHP-1 to the Epidermal Growth Factor Receptor and Attenuation of Receptor Signaling
157 Citations1998Heike Keilhack, Tencho Tenev +5 more
Reduced SHP-1 binding to the EGFR Y1173F mutant resulted in a reduced receptor dephosphorylation by coexpressed SHp-1 and less interference with EGF-dependent mitogen-activated protein kinase stimulation.
OncogeneEffects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells
157 Citations2000Richard M. Neve, Hedwig Sutterlüty +5 more
It is proposed that c-Myc is a primary effector of ErbB2-mediated oncogenicity and functions to prevent normal p27Kip1 control of cyclinE/CDK2.
Journal of Biological ChemistryIntracellular expression of single chain antibodies reverts ErbB-2 transformation.
155 Citations1994Roger R. Beerli, Winfried S. Wels +1 more
This is the first demonstration of a targeted and stable inactivation of a cellular oncoprotein via intracellular antibody expression and represents a simple and powerful approach to study the in vivo function of receptors and other cellular proteins.
PubMedCoupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.
155 Citations1996Gil Levkowitz, Klapper Ln +4 more
In vitro experiments suggest that a candidate mediator of the interaction is the Grb-2/Ash adaptor protein, which is constitutively bound to c-Cbl, and indicate that different ErbB proteins can couple to distinct signaling pathways, and therefore their physiological functions are probably non-redundant.
Molecular and Cellular BiologyDistinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation
150 Citations1997David Dankort, Zhixiang Wang +3 more
It is argued that the transforming potential of activated neu is mediated both by positive and negative regulatory tyrosine phosphorylation sites.
Journal of Biological ChemistryThe Role of Individual SH2 Domains in Mediating Association of Phospholipase C-γ1 with the Activated EGF Receptor
144 Citations1999Ansuman Chattopadhyay, Manuela Vecchi +3 more
The combined results suggest an association mechanism involving the N-SH2 domain and the pY1173 autophosphorylation site as a primary event and the C-SH1 domain and a secondary event in the PLC-γ1 association with the EGF receptor.
PubMedGrowth regulation of human breast and ovarian tumor cells by heregulin: Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness.
142 Citations1996G D Lewis, James A. Lofgren +5 more
It is shown that ErbB2 is a critical component in mediating HRG responsiveness in a panel of human breast and ovarian tumor cell lines and that methods for measuring cell proliferation, as well as experimental conditions, are critical for determining HRGs effect on tumor cell growth in vitro.
Biochemical and Biophysical Research Communicationsc-SRC Phosphorylates Epidermal Growth Factor Receptor on Tyrosine 845
141 Citations1995Kenichi Sato, Asomi Sato +2 more
Results suggest that c-Src can phosphorylate EGF receptor on Y845 in an EGF-dependent manner, and confirm that the same site of the c- Src-associated EGF receptors was phosphorylated in E GF-treated A431 cells.
DevelopmentHeparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation
139 Citations1999Bibhash C. Paria, Klaus Elenius +2 more
To delineate which EGF receptors participate in blastocyst activation, the toxicity of chimeric toxins composed of HB-EGF or TGF-(&agr;) coupled to Pseudomonas exotoxin (PE) were used as measures of receptor expression and ErbB4 is a candidate for being an HB- EGF-responsive receptor.
Biochemical JournalDistribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family
135 Citations1997Hitoshi Toyoda, Toshi Komurasaki +2 more
The findings suggest that epiregulin is involved in certain physiological processes such as maintenance or development of normal cell growth, and the progression of carcinomas.
Journal of Biological ChemistryThe Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells
125 Citations1996Bruce D. Cohen, Peter A. Kiener +4 more
Heregulin induced cellular transformation by activating HER3- and HER4-containing complexes does not require the activation of either phospholipase Cγ1 or the mobilization of intracellular calcium.
Molecular and Cellular BiologyInteractions of <i>Drosophila</i> Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development
121 Citations1997Herman Meisner, Andrea Daga +5 more
D-Cbl functions as a negative regulator of receptor tyrosine kinase signaling in the Drosophila eye by a mechanism that involves its association with EGF receptors or other tyrosin kinases.
Molecular EndocrinologyTargeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in the Mammary Gland of Transgenic Mice Inhibits Pubertal Mammary Duct Development
120 Citations1997Wen Xie, Andrew J. Paterson +3 more
A transgenic mouse model demonstrates that the EGFR-TR behaves as a dominant negative regulator of the EG FR system in vivo and that the EGF receptor (EGFR) system plays an important role in mammary ductal development.
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