The Lipid Treatment Assessment Project (L-TAP)
Archives of Internal MedicinePublished 28 February 2000
Thomas A. Pearson, Irene Laurora, Henry Chu, S D Kafonek
Citations1,008
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Large proportions of dyslipidemic patients receiving lipid-lowering therapy are not achieving NCEP LDL-C target levels, indicating that more aggressive treatment of Dyslipidemia is needed to attain goals established by N CEP guidelines.
Abstract
Large proportions of dyslipidemic patients receiving lipid-lowering therapy are not achieving NCEP LDL-C target levels. These findings indicate that more aggressive treatment of dyslipidemia is needed to attain goals established by NCEP guidelines.
Keywords
MedicineEconomics, Econometrics and Finance
Clinical ChemistryEstimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
32,475 Citations1972William T. Friedewald, Robert I. Levy +1 more
A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
JAMASummary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
27,886 Citations1993Scott M. Grundy
Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Clinical ChemistryEnzymatic Determination of Total Serum Cholesterol
9,168 Citations1974Charles C. Allain, Lucy S Poon +3 more
An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent and has excellent precision.
New England Journal of MedicineThe Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
7,491 Citations1996Frank M. Sacks, Marc A. Pfeffer +10 more
It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol.
New England Journal of MedicinePrevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
7,453 Citations1995James Shepherd, Stuart M. Cobbe +6 more
Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
JAMAPrimary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels
5,269 Citations1998John R. Downs, Michael Clearfield +8 more
Lovastatin reduces the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL- C levels and supports the inclusion of HDL-C in risk-factor assessment and the need for reassessment of the National Cholesterol Program guidelines.
New England Journal of MedicineHelsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
3,875 Citations1987M. H. Frick, Olli Elo +17 more
Results are in accord with two previous trials with different pharmacologic agents and indicate that modification of lipoprotein levels with gemfibrozil reduces the incidence of coronary heart disease in men with dyslipidemia.
PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA
3,460 Citations1995J Ames S Hepherd, S Tuart M. C Obbe +7 more
Archives of Internal MedicineReport of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
2,298 Citations1988DeWitt S. Goodman
New guidelines for the treatment of high blood cholesterol in adults 20 years of age and over are provided and which patients should go on to have lipoprotein analysis, and which should receive cholesterol-lowering treatment on the basis of their low density lipop protein levels and status with respect to other coronary heart disease risk factors are detailed.
PubMedIncidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study.
2,267 Citations1986William P. Castelli, Robert J. Garrison +4 more
Clinical ChemistryDextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol.
2,182 Citations1982G. Russell Warnick, J Benderson +1 more
Statistics in MedicineA COMPARISON OF GOODNESS-OF-FIT TESTS FOR THE LOGISTIC REGRESSION MODEL
1,805 Citations1997D Hosmer, Trina Hosmer +2 more
An examination of the performance of the tests when the correct model has a quadratic term but a model containing only the linear term has been fit shows that the Pearson chi-square, the unweighted sum-of-squares, the Hosmer-Lemeshow decile of risk, the smoothed residual sum- of-Squares and Stukel's score test, have power exceeding 50 per cent to detect moderate departures from linearity.
Clinical ChemistryA peroxidase-coupled method for the colorimetric determination of serum triglycerides.
1,304 Citations1983M. McGowan, Joseph D. Artiss +2 more
This sensitive chromogen system not only permits use of unusually small sample volumes, it also facilitates a linear response to serum triglyceride concentrations up to at least 10 g/L while displaying good Ringbom (measure of accuracy) characteristics.
Archives of Internal MedicineSerum Cholesterol Level and Mortality Findings for Men Screened in the Multiple Risk Factor Intervention Trial
661 Citations1992James D. Neaton
The association of serum cholesterol with specific causes of death varies in direction, strength, gradation, and persistence, and further research on the determinants of low serum cholesterol level in populations and long-term follow-up of participants in clinical trials is necessary.
JAMAAdherence to National Cholesterol Education Program Treatment Goals in Postmenopausal Women With Heart Disease
250 Citations1997Helmut G. Schrott
The majority of women enrolled in the trial had LDL-C levels that significantly exceeded the treatment goals set by the 1988 and 1993 Adult Treatment Panel guidelines, and better implementation of these guidelines among women with coronary disease would be highlyd desirable.
The American Journal of MedicineInadequate treatment with HMG-CoA reductase inhibitors by health care providers
168 Citations1996Jennifer J. Marcelino, Kenneth R. Feingold
Based on the current NCEP recommendations, patients on monotherapy with HMG-CoA reductase inhibitors are often inadequately treated and less than half of the patients were adequately monitored for hepatotoxicity.
The American Journal of MedicineDrug therapy for hypercholesterolemia in patients with cardiovascular disease: Factors limiting achievement of lipid goals
165 Citations1996Gordon Schectman, Jan Hiatt
Multivariate analysis indicated that lower baseline LDL-C and triglycerides, use of combinations of drug therapy rather than monotherapy, and patient adherence to treatment predicted the achievement of goal lipid levels.
Medical Decision MakingThe Covariance Decomposition of the Probability Score and Its Use in Evaluating Prognostic Estimates
129 Citations1995Hal R. Arkes, N V Dawson +8 more
The authors suggest that the calculational simplicity of this decomposition, its informative- ness, and the intuitive nature of its components make it a useful tool with which to analyze medical judgment.
Annals of Internal MedicineEffect of Combination Therapy with Lipid-Reducing Drugs in Patients with Coronary Heart Disease and “Normal” Cholesterol Levels
85 Citations1996Richard C. Pasternak, Lisa E. Brown +5 more
The objective was to evaluate the efficacy and tolerability of a rationally designed program of stepped-care therapy for normolipidemic patients with coronary heart disease and to meet target goals for the aggressive reduction of LDL cholesterol levels.
