INTERRELATIONS OF VITAMIN B12 AND FOLIC ACID METABOLISM: FOLIC ACID CLEARANCE STUDIES*
Journal of Clinical InvestigationPublished 1 June 1962Open access
Victor Herbert, Ralph Zalusky
Citations510
SJR quartileQ1
SJR score4.72
SNIP2.17
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TL;DR
Preliminary results of part of these studies suggest that folic acid activity "piles up" in human serum in the presence of vitamin B12 deficiency, and provides direct evidence of deranged folic Acid metabolism due to vitamin B 12 deficiency.
Keywords
Medicine
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The method described is a valuable method for differentiating patients requiring treatment with folic acid from normal subjects and patients with primary vitamin B12 deficiency and the activity lost during the storage of serum not protected by ascorbic acid could be restored, for periods up to three months, by adding ascorBic acid to serum that is to be stored.
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128 Citations1961J. Kohn, D. L. Mollin +1 more
A new method for the determination of urinary formiminoglutamic acid (FIGLU) using conventional electrophoresis at 200 to 500 v. on cellulose acetate strips is reported, showing it to be a simple, practical, and apparently sensitive method.
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118 Citations1960Victor Herbert, Herman Baker +6 more
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The inclusion in this volume of over 600 references indicates the thoroughness with which Dr. Herbert has reviewed the literature on the megaloblastic anemias.
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51 Citations1953Herbert Tabor, Milton Silverman +3 more
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47 Citations1960R. H. Girdwood
Methods of measuring folic acid quantitatively, particularly by microbiological methods, are dealt with and an account of ways of investigating patients believed to be suffering from folic Acid deficiency is discussed.
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38 Citations1962Ralph Zalusky
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33 Citations1955C.F. Hawkins
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30 Citations1962William S. Beck
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Experimental Biology and MedicineDetection and Isolation of Formiminoglutamic Acid from Urine in Folic Acid Deficiency in Humans.,
30 Citations1959Harry P. Broquist, A. Leonard Luhby
It is suggested that determination of FIGLU in human urine may be a useful aid in diagnosing folic acid deficiency in man.
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It has been demonstrated that extracts of human livers prepared with potassium ascorbate contain a derivative which is very active in supplying the FA requirement for L. casei, but only slightly so for P. cerevisiae or S. faecalis.
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17 Citations1960M. Silverman, Rita C. Gardiner +1 more
Dietary ethionine blocks the metabolism of histidine in the rat at the level of urocanic acid and induces the urinary excretion of this metabolite, and high concentrations of dietary fat tend to lower the folic acid and vitamin B 12 concentrations of the liver; consequently, theexcretion of formiminoglutamic acid is increased.
BMJConversion of Folic Acid to the Citrovorum Factor in Health and Pernicious Anaemia
16 Citations1952G. H. Spray, L. J. Witts
The authors' thanks are due to Mr. C. Ricketts, for the electrophoresis; and to Miss S. Baar for technical help.
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5 Citations1961Thomas H. Jukes, Harry P. Broquist
The close biogenetic relationship that appears to exist between folic acid and riboflavin is further borne out by a recent study of Clapper and Meade who found that when the amount of folic hydrochloric acid required for growth of a strain of Streptococcus faecalis was limiting, the number of rib oflavin synthesized by the organism was depressed.
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5 Citations1960M.R. Spivey Fox, Walter Ludwig +2 more
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