Acute Poisoning by Tricyclic Antidepressants: Clinical Features and Management of 100 Patients
Clinical toxicologyPublished 1 January 1969
Jonathan Noble, Henry Matthew
Citations117
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
(1969). Acute Poisoning by Tricyclic Antidepressants: Clinical Features and Management of 100 Patients. Clinical Toxicology: Vol. 2, No. 4, pp. 403-421.
Keywords
Medicine
Journal of Pharmacology and Experimental TherapeuticsSPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI)
245 Citations1964James V. Dingell, Fridolin Sulser +1 more
Evidence presented in this paper indicates that differences in the metabolism of imipramine and DMI may partially explain the species variations in the pharmacologic response of these "antisedative" compounds.
BMJClinical effects and treatment of imipramine and amitriptyline poisoning in children.
150 Citations1967Catherine Steel, J. Desmond O’Duffy +1 more
Imipramine and amitriptyline are tricyclic antidepressant compounds whose chemical structure, dosage, pharmacology, and toxicity are so similar that they are commonly considered together.
BMJGastric aspiration and lavage in acute poisoning.
104 Citations1966Henry Matthew, T. F. Mackintosh +2 more
Ampicillin appears to be at least as effective as penicillin and streptomycin even in the comparatively small doses used in this trial, and there would appear to be an advantage in domiciliary practice in using a drug that can be given by mouth, and if an allowance is made for the cost of giving injections there is little difference in the expense.
American journal of diseases of childrenAmitriptyline Poisoning
70 Citations1963Philip Sunshine
The purpose of this communication is to present the symptoms and postmortem findings in an infant who died after the accidental ingestion of a massive amount of amitriptyline hydrochloride and to report the ineffectiveness of peritoneal dialysis in removing the ingested drug.
BMJOccurrence of Bullous Lesions in Acute Barbiturate Intoxication
69 Citations1965G. W. Beveridge, A. A. H. Lawson
BMJImipramine Poisoning in Childhood
67 Citations1963Howard Giles
In this series of 80 ovarian tumours found in postmenopausal women, it appears that of the three major types of ovarian tumour in this series the serous cystadenomas produce oestrogen more commonly than any other.
New England Journal of MedicineManagement of Massive Imipramine Overdosage with Mannitol and Artificial Dialysis
59 Citations1963J. Warren Harthorne, Anthony Marcus +1 more
IMIPRAMINE hydrochloride (Tofranil), the chemical analogue of promazine in the phenothiazine series, has the chemical formula of 5-(3-dimethyl-aminopropyl)-10,ll, dihydro-5H-dibenz (b, f) azepine h...
BMJDelayed death in imipramine poisoning.
35 Citations1967A. B. Masters
This child's very ill condition was recognized and duly treated because of his social connexion with me, a child psychiatrist, and the giving of "sex education" to persons in a defenceless position in a class situation before they are sufficiently mature to face these stark, staring realities is called for.
BMJImipramine Overdosage--Report of a Fatal Case
34 Citations1961F. I. Lee
There seems to be little doubt, however, that in the present case a definite remission had been induced by giving cortisone, even though spontaneous improvement had been noticed at this time of the year during previous relapses.
JAMAImipramine Hydrochloride Intoxication
27 Citations1962Harvey F. Garrison
Its most useful action has been in periodic endogenous depressive states, in which it often eliminates the need for electroconvulsive therapy or markedly reduces the number of shock treatments needed.
NatureA Fatal Case of Poisoning with Amitriptyline
25 Citations1963Irving Sunshine, J. Bäumler
A fatal episode involving amitriptyline, another new drug in the fast growing list of psychopharmacological drugs, is reported.
Journal of Pharmacy and PharmacologySeven fatal cases involving imipramine in man
21 Citations1964A. S. Curry
The results of the distribution of imipramine in various organs are reported for four cases of acute overdosage and three cases in which the dose was probably therapeutic, with much lower concentrations of the drug than in the liver brain and kidney.
American Journal of PsychiatryCONVULSIONS ASSOCIATED WITH ANTI-DEPRESSANT DRUGS
21 Citations1960W. L. SHARP
From the results of three cases developing epileptiform seizures, out of 58 cases, which have been on the more commonly used MAO drugs, it would appear that the authors could expect this unwelcome reaction in about 4 or 5% of cases.
Scottish Medical JournalMyocardial Damage in Amitriptyline and Nortriptyline Poisoning
16 Citations1968R. G. Brackenridge, T. J. Peters +1 more
Two patients showed transient E.C.G. changes and two had a rise in the serum enzymes usually associated with myocardial necrosis, and two cases of self-poisoning with amitriptyline and one with nortriptylines are described.
Journal of the Forensic Science SocietyAmitriptyline Poisoning
12 Citations1965Gilbert Forbes, Walter Pollock Weir +2 more
BMJTreatment of poisoning by antidepressant drugs
7 Citations1967C. A. Fuge
It is considered that the resulting mortality and morbidity would be greater than that from aspirin poisoning, and certainly would not warrant acceptance of the change you have so strongly advocated, and should the advice of your leader be accepted.
BMJTreatment of poisoning by antidepressants
1 Citations1967B. J. Prout
The present stupendous amphetamine consumption, legitimate and otherwise, was initiated by ourselves, just as the overconsumption of barbiturates is a legacy of the sedative era.