Alcohol drinking in rats during and following morphine injections
AlcoholPublished 1 July 1991
Joseph R. Volpicelli, Ronald R. Ulm, Natalie Hopson
Citations61
SJR quartileQ2
SJR score0.70
SNIP0.78
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TL;DR
The results were interpreted as supporting the theory that alcohol drinking is reinforced through its interaction with the endogenous opioid system and can compensate for deficiencies in opioid receptor activity.
Abstract
Adult male Sprague-Dawley rats given daily SC injections of 2.5 mg/kg or 10 mg/kg morphine sulfate (for eight days) decreased preference for a 5% (v/v) ethanol solution, and then increased ethanol preference during the postinjection period, relative to a saline control group. These bidirectional effects were directly related to morphine dosage. The results were interpreted as supporting the theory that alcohol drinking is reinforced through its interaction with the endogenous opioid system and can compensate for deficiencies in opioid receptor activity.
Keywords
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