Identification of Thiazolidinones Spiro‐Fused to Indolin‐2‐ones as Potent and Selective Inhibitors of the <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B
Angewandte Chemie International EditionPublished 14 July 2010
Viktor V. Vintonyak, Karin Warburg, Holger Kruse, Stefan Grimme, Katja Hübel, Daniel Rauh
Citations292
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
The best of 40 000: Detailed structure–activity-relationship studies revealed key structural elements of indolin-2-on-3-spirothiazolidinones (see example) and their appropriate configuration for strong inhibitory activity against the pathophysiologically relevant title protein.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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