Active Site Design in a Chemzyme: Development of a Highly Asymmetric and Remarkably Temperature-Independent Catalyst for the Imino Aldol Reaction This work was supported by a grant from UOP Company. We would like to thank Thomas Malloy, Timothy Brandvold and Beth McCulloch for stimulating discussions.

A remarkably temperature-independent catalyst has been developed for the imino aldol reaction of imines derived from ortho-aminophenols that resulted in asymmetric inductions in excess of 98 % ee at room temperature as well as at 100°C.

Abstract

) should enhance induction. This resulted in asymmetric inductions in excess of 98 % ee at room temperature as well as at 100°C. TMS=trimethylsilyl.