Carcinogenicity in rats of the mutagenic compounds 1-nitropyrene and 3-nitrofluoranthene
Cancer LettersPublished 1 January 1982
Hiroko Ohgaki, Norio Matsukura, Kazuhide Morino, Takashi Kawachi, Takashi Sügimura, K Morita
Citations157
SJR quartileQ1
SJR score2.76
SNIP1.54
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TL;DR
Sarcomas, mainly malignant fibrous histiocytomas at the site of injection were induced in 8 to 17 rats by 1-nitropyrene and in 4 of 10 rats by 3-nitrofluoranthene, and some tumors were serially transplantable in the same strain of rats.
Abstract
1-Nitropyrene and 3-nitrofluoranthene are present in diesel exhaust, in pollutants in air, and were also present in certain xerographic toners and copies. Their carcinogenicities were studied in male F344/DuCrj rats by subcutaneous injection. Sarcomas, mainly malignant fibrous histiocytomas at the site of injection were induced in 8 to 17 (47%) rats by 1-nitropyrene and in 4 of 10 (40%) rats by 3-nitrofluoranthene. Some tumors were serially transplantable in the same strain of rats.
Keywords
Biochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsEnvironmental Science
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