Ischaemic preconditioning
BMJPublished 1 January 1994
Michael Marber, David Walker, Derek M. Yellon
Citations56
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TL;DR
The currently favoured hypotheses propose that substances generated as a consequence of preconditioning can modulate the myocardial response to further ischaemia and suggest the possible involvement of one or more of adenosine, nitric oxide,4 prostacyclin,6 and free radicals.
Keywords
MedicineNeuroscience
CirculationProtection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.
1,346 Citations1991G. S. Liu, J D Thornton +4 more
Adenosine released during the preconditioning occlusion stimulates cardiac A 1 receptors, which leaves the heart protected against infarction even after the adenosine has been withdrawn.
The LancetPreconditioning the human myocardium
709 Citations1993Derek M. Yellon, Abdulaziz Alkhulaifi +1 more
The results are the first to show that it may be possible to precondition and protect the human myocardium with short controlled periods of intermittent ischaemia and reperfusion.
CirculationAdaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.
596 Citations1990Ezra Deutsch, Mark Berger +4 more
It is concluded that the lessened clinical, electrocardiographic, hemodynamic, and metabolic evidence of myocardial ischemia during the second of two periods of coronary artery occlusion during percutaneous transluminal coronary angioplasty supports the concept of adaptation to myocardia (ischemic preconditioning).
Journal of the American College of CardiologyImproved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: A prospective study
244 Citations1992Alain Cribier, Luis Korsatz +7 more
An improved tolerance to myocardial ischemia with repetitive coronary occlusions was demonstrated by a significant reduction of angina, ST segment deviation, left ventricular filling pressure and less impairment of ejection fraction, suggesting that enhancement of recruitable collateral circulation might be an underlying mechanism of myocardian ischemic preconditioning.
Cardiovascular ResearchProtective effects of preconditioning of the ischaemic myocardium involve cyclo-oxygenase products
148 Citations1990Á Végh, L. Szekeres +1 more
Short, preconditioning periods of myocardial ischaemia protect the myocardium against the arrhythmogenic effects of a more prolonged occlusion, and that this protection is lost if the cyclo-oxygenase pathway is blocked suggests a protective role for prostanoids, most likely prostacyclin, as endogenousMyocardial protective substances.
American Heart JournalRelationship between antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial infarction
135 Citations1990David W.M. Muller, Eric J. Topol +7 more
Findings suggest that a history of prior angina is not necessarily associated with an unfavorable short-term prognosis after reperfusion therapy, and may be related to the beneficial effects of collateral vessels, myocardial preconditioning, or differences in the native fibrinolytic system.
Cardiovascular ResearchIschaemic preconditioning: from mechanisms to exploitation
109 Citations1992David Walker, Derek M. Yellon
PubMedThe influence of the time period between preconditioning ischemia and prolonged ischemia on myocardial protection.
48 Citations1993A M Alkhulaifi, W. B. Pugsley +1 more
The results show that the minimum period of reperfusion required to give protection after preconditioning ischemia lies between 30 seconds and 1 minute.